1.
Org Lett
; 22(12): 4823-4827, 2020 06 19.
Artículo
en Inglés
| MEDLINE
| ID: mdl-32521158
RESUMEN
Challenging Suzuki-Miyaura cross couplings associated with novel crop protection active ingredients from Corteva Agriscience, Arylex and Rinskor, can be performed in water using parts per million (ppm) levels of a Pd catalyst. Each coupling required a distinct set of reaction conditions to achieve maximum selectivities and chemical yields. By way of comparison, this chemistry is not only performed under environmentally responsible aqueous micellar conditions, but also involves lowering loadings (3-5 times) of endangered palladium than used previously to attain a more sustainable process.