RESUMEN

A photoionization hydrogen laser time-of-flight mass spectrometer system (H2-TOFMS) has been evaluated for the rapid analysis of drugs of abuse and pharmaceutical agents extracted from prescription tablets and spiked urine samples. The spectra obtained using the H2-TOFMS showed primarily intact molecular ions (M+*) after introduction by a heated probe and irradiation with vacuum ultraviolet (VUV) photons from the laser. Samples analyzed by this technique required only a simple solid-phase extraction step; no chromatographic separation or derivatization was necessary to identify the drugs of abuse or pharmaceutical agents.

Asunto(s)

Acetaminofén/orina , Preparaciones Farmacéuticas/química , Humanos , Rayos Láser , Espectrometría de Masas/métodos , Espectrometría de Masa por Ionización de Electrospray/métodos , Espectrofotometría Ultravioleta/métodos , Trastornos Relacionados con Sustancias