RESUMEN
An aortic stent graft has been fatigue tested in a system that operates at a frequency of 50 Hz. The mode of operation and the results that supplement finite element model calculations are described.
Asunto(s)
Materiales Biocompatibles/química , Prótesis Vascular , Análisis de Falla de Equipo/instrumentación , Análisis de Falla de Equipo/métodos , Ensayo de Materiales/instrumentación , Ensayo de Materiales/métodos , Stents , Simulación por Computador , Diseño Asistido por Computadora , Elasticidad , Diseño de Equipo/instrumentación , Diseño de Equipo/métodos , Análisis de Elementos Finitos , Modelos TeóricosRESUMEN
A micro-structured, biodegradable, semipermeable hollow nerve guide implant was developed to bridge nerve lesions. Quantitative comparison of cell migration and axonal growth using time lapse video recording in vitro revealed that axons grow eight times faster than neuritotrophic Schwann cells migrate. To accelerate regeneration, purified Schwann cells are best injected into nerve guides before implantation. Nerve guides made from resorbable poly-lactide-co-glycolide support Schwann cell attachment, cell survival, and axonal outgrowth in vitro. The therapeutic concept aims at the development of an 'intelligent neuroprosthesis' that first mediates regeneration and then disappears.