RESUMEN

Two hours after treatment with beta-bungarotoxin (0.34-0.4 microM), when there was complete neuromuscular block, the peak contracture response to 50 microM succinylcholine was significantly reduced by about 35% in the mouse phrenic nerve-diaphragm preparation. Additionally, significant phospholipase A2 activity was detected on primary cell cultures from skeletal muscle which were incubated for 2 hr with concentrations of beta-bungarotoxin greater than or equal to 0.1 microM. Thus, beta-bungarotoxin appears to have pharmacologically and biochemically detectable postsynaptic actions in mammalian muscle systems.

Asunto(s)

Bungarotoxinas/toxicidad , Músculos/efectos de los fármacos , Unión Neuromuscular/efectos de los fármacos , Fosfolipasas A/metabolismo , Animales , Células Cultivadas , Masculino , Ratones , Músculos/enzimología , Fosfolipasas A2 , Succinilcolina/farmacología