RESUMEN
AIM: To investigate the association between the use of cellular or cordless telephones and the risk for salivary gland tumours. METHODS: Cases were assessed from the six regional cancer registries in Sweden. Four controls matched for sex and age in five year age groups were selected for each case. A total of 293 living cases and 1172 controls were included. RESULTS: There were 267 (91%) participating cases and 1053 (90%) controls. Overall no significantly increased risk was found. Odds ratios were 0.92 (95% CI 0.58 to 1.44) for use of analogue phones, 1.01 (95% CI 0.68 to 1.50) for use of digital phones, and 0.99 (95% CI 0.68 to 1.43) for use of cordless phones. Similar results were found for different salivary gland localisations. No effect of tumour induction period or latency was seen, although few subjects reported use for more than 10 years. CONCLUSIONS: No association between the use of cellular or cordless phones and salivary gland tumours was found, although this study does not permit conclusions for long term heavy use.
Asunto(s)
Neoplasias de las Glándulas Salivales/etiología , Teléfono , Adulto , Anciano , Anciano de 80 o más Años , Estudios de Casos y Controles , Teléfono Celular , Intervalos de Confianza , Exposición a Riesgos Ambientales/efectos adversos , Femenino , Humanos , Masculino , Microondas/efectos adversos , Persona de Mediana Edad , Oportunidad Relativa , Neoplasias de la Parótida/etiología , Neoplasias de la Parótida/patología , Factores de Riesgo , Neoplasias de las Glándulas Salivales/patología , Neoplasias de la Glándula Submandibular/etiología , Neoplasias de la Glándula Submandibular/patología , Factores de TiempoRESUMEN
A group of 133 primary oral squamous cell carcinomas were studied concerning a relationship between exposure factors and tumour biological parameters with a focus on the TP53 gene and p53 protein status. Tumours were evaluated using immunohistochemistry (IHC) for expression of p53, PCNA, Ki-67 and bcl-2 proteins. The TP53 gene was studied for mutations using PCR amplification of exons 5-9 and single strand conformation polymorphism (SSCP) analysis. The collected data were correlated to the exposure factors smoking, oral snuff, liquor, oral infections, dental factors, dental X-ray and iron deficiency. When compared with matched controls only oral infections, and reported HSV-infections in particular, gave statistically significant ORs (odds ratio) for all tumours (OR 8.0) as well as for the group of IHC p53 positive tumours (OR 12). No association between smoking and p53 positivity was found (OR 1.0).
Asunto(s)
Antígeno Ki-67/biosíntesis , Neoplasias de la Boca/genética , Neoplasias de la Boca/metabolismo , Antígeno Nuclear de Célula en Proliferación/biosíntesis , Proteínas Proto-Oncogénicas c-bcl-2/biosíntesis , Proteína p53 Supresora de Tumor/biosíntesis , Carcinoma de Células Escamosas/epidemiología , Carcinoma de Células Escamosas/genética , Carcinoma de Células Escamosas/metabolismo , Estudios de Casos y Controles , División Celular , Línea Celular Tumoral , Exones , Genes p53 , Humanos , Inmunohistoquímica , Neoplasias de la Boca/epidemiología , Mutación , Oportunidad Relativa , Reacción en Cadena de la Polimerasa , Polimorfismo Conformacional Retorcido-Simple , Factores de Riesgo , Proteína p53 Supresora de Tumor/metabolismo , Rayos XRESUMEN
In a case-control study with 410 cases and 410 matched controls from the period 1980-1989 we investigated the role of occupations and occupational exposures as risk factors for squamous cell oral cancer. All subjects received a questionnaire. The response rates were 96% and 91% for cases and controls, respectively. A significantly increased risk was found for pulp industry workers, odds ratio (OR) 4.0 and wood or product workers, OR 5.5. Exposure to chemicals such as phenoxyacetic acids yielded an OR of 1.7. The positive findings in this study may be explained by exposure to chemicals, but need to be verified in further studies.
Asunto(s)
Carcinoma de Células Escamosas/epidemiología , Neoplasias de la Boca/epidemiología , Exposición Profesional , Ocupaciones , Anciano , Carcinoma de Células Escamosas/etiología , Carcinoma de Células Escamosas/mortalidad , Carcinoma de Células Escamosas/patología , Estudios de Casos y Controles , Femenino , Humanos , Masculino , Neoplasias de la Boca/etiología , Neoplasias de la Boca/mortalidad , Neoplasias de la Boca/patología , Oportunidad Relativa , Sistema de Registros , Análisis de Regresión , Factores de Riesgo , Encuestas y Cuestionarios , Suecia/epidemiología , MaderaRESUMEN
We investigated the role of oral infections, dentition and dental X-rays for oral cancer in a north Swedish population. This case-control study consisted of 410 cases with oral cancer for the period 1980-89 and 410 matched controls. All subjects received a mailed questionnaire. The response rates were 96% and 91% for cases and controls, respectively. The univariate analysis showed a statistically significant increased risk for oral cancer among individuals reporting problems with recurrent clinical oral infection (odds ratio (OR) 3.8). Separate analyses were made for groups with a clearly stated HSV-1 infection (OR 1.9) and highly suspected HSV-1 infection (OR 3.3) as reported by the subjects. Odds ratios were also calculated for infections in relation to tobacco and alcohol habits. For individuals reporting recurrent infection problems an increased risk was observed in every combination category. Dental factors such as different fillings, dentures and fixed prostheses showed no increased risks. Dental X-ray did not produce an increased OR either. A multivariate analysis suggested that the most important risk factors were oral infections followed by liquor consumption and active smoking.
Asunto(s)
Carcinoma de Células Escamosas/epidemiología , Neoplasias de la Boca/epidemiología , Consumo de Bebidas Alcohólicas , Carcinoma de Células Escamosas/etiología , Estudios de Casos y Controles , Dentición , Herpes Simple , Humanos , Enfermedades de la Boca/virología , Neoplasias de la Boca/etiología , Análisis Multivariante , Factores de Riesgo , Fumar , Suecia/epidemiologíaRESUMEN
The use of oral snuff is a widespread habit in Sweden. We investigated whether the use of Swedish moist snuff leads to an increasing risk of oral cancer. Other risk factors such as smoking tobacco and alcoholic beverages were also investigated. Our study comprised 410 patients with oral cancer, from the period 1980-1989, and 410 matched controls. All subjects received a mailed questionnaire. The response rates were 96% and 91% for cases and controls, respectively. In the study, a total of 20% of all subjects, cases and controls, were active or ex-snuff users. The univariate analysis did not show any increased risk [odds ratio (OR) 0.7, 95% confidence interval (CI) 0.4-1.1] for active snuff users. We found an increased risk (OR 1.8, CI 1.1-2.7) for oral cancer among active smokers. Alcohol consumption showed the strongest risk for oral cancer. Among consumers of beer, an increased risk of 1.9 (CI 0.9-3.9) was found. Corresponding ORs for wine and liquor were 1.3 (CI 0.9-1.8) and 1.6 (CI 1.1-2.3), respectively. A dose-response effect was observed. Although not statistically significant, a multivariate analysis similarly suggested that the most important risk factors were beer and liquor consumption, followed by smoking.
Asunto(s)
Consumo de Bebidas Alcohólicas , Neoplasias de la Boca/epidemiología , Plantas Tóxicas , Fumar , Tabaco sin Humo , Factores de Edad , Bebidas Alcohólicas , Análisis de Varianza , Cerveza , Estudios de Casos y Controles , Intervalos de Confianza , Femenino , Humanos , Masculino , Neoplasias de la Boca/etiología , Neoplasias de la Boca/mortalidad , Análisis Multivariante , Oportunidad Relativa , Sistema de Registros , Caracteres Sexuales , Encuestas y Cuestionarios , Suecia/epidemiología , VinoRESUMEN
Eighty patients with primary intraoral squamous cell carcinomas of the head and neck, with a follow-up of 4-14 years were analysed for clinical outcome in relation to immunohistochemical expression of PCNA, Ki-67, p53, bcl-2 and presence of mutations in the p53 gene. The tumor site was not associated with the different parameters calculated. PCNA and Ki-67 labelling showed median values of 56% and 32%, respectively, and neither antigen was of predictive value. Fifty-five percent of the tumours expressed p53, and 38 (48%) had mutations in the p53 gene. No association between the presence of p53 protein or mutations in the p53 gene and clinical outcome was found. Bcl-2 positivity was detected in a minor fraction (10%) of the tumours.
Asunto(s)
Carcinoma de Células Escamosas/diagnóstico , Neoplasias de Cabeza y Cuello/diagnóstico , Antígeno Ki-67/análisis , Antígeno Nuclear de Célula en Proliferación/análisis , Proteínas Proto-Oncogénicas c-bcl-2/análisis , Proteína p53 Supresora de Tumor/análisis , Adulto , Anciano , Anciano de 80 o más Años , Apoptosis , Carcinoma de Células Escamosas/química , Carcinoma de Células Escamosas/mortalidad , División Celular , Análisis Mutacional de ADN , ADN de Neoplasias/análisis , Femenino , Estudios de Seguimiento , Neoplasias de Cabeza y Cuello/química , Neoplasias de Cabeza y Cuello/mortalidad , Humanos , Inmunohistoquímica , Antígeno Ki-67/genética , Masculino , Persona de Mediana Edad , Polimorfismo Conformacional Retorcido-Simple , Valor Predictivo de las Pruebas , Pronóstico , Antígeno Nuclear de Célula en Proliferación/genética , Proteínas Proto-Oncogénicas c-bcl-2/genética , Análisis de Supervivencia , Proteína p53 Supresora de Tumor/genéticaRESUMEN
In a retrospective study of the mutational spectrum of the p53 gene in oral squamous cell carcinoma, 80 primary tumours diagnosed in 1980-90 were included. Using polymerase chain reaction/single strand conformation polymorphism (PCR/SSCP) analysis 47 mutations were found distributed in 39 of the tumours (49%). Unexpectedly, the majority of the mutations (29/47; 62%) were found in exon 8, and at sequencing 17 of them showed a 14 bp deletion in codons 287-292, causing formation of a stop codon and accordingly a truncated protein lacking the C-terminal. The majority of the patients with the 14 bp deletion were women (13/17), and it seemed as though certain potential risk factors for carcinoma of the head and neck were less common in this group.
Asunto(s)
Carcinoma de Células Escamosas/genética , Genes p53 , Neoplasias de la Boca/genética , Eliminación de Secuencia , Factores de Edad , Anciano , Secuencia de Bases , Carcinógenos , Carcinoma de Células Escamosas/epidemiología , Carcinoma de Células Escamosas/patología , Codón , Cartilla de ADN , Exposición a Riesgos Ambientales , Exones , Femenino , Humanos , Masculino , Datos de Secuencia Molecular , Neoplasias de la Boca/clasificación , Neoplasias de la Boca/epidemiología , Neoplasias de la Boca/patología , Mutación Puntual , Reacción en Cadena de la Polimerasa , Polimorfismo Conformacional Retorcido-Simple , Estudios Retrospectivos , Factores de Riesgo , Caracteres Sexuales , FumarRESUMEN
Field studies were conducted in central Sweden from 1983 through 1985 to obtain information on the etiologic agent of Ockelbo disease, described in Sweden in the 1960s and probably identical to Pogosta disease in Finland and to Karelian fever in the western USSR. Mosquitoes (63,644) collected during this 3 year period yielded 21 virus strains. Ockelbo virus isolations were from Culiseta morsitans (5 strains), Culex pipiens and/or Cx. torrentium (6 strains), and Aedes cinereus (3 strains). Inkoo (6 strains) and Batai (1 strain) viruses were recovered from Ae. communis. Blood samples collected March-May from migrating birds on the southeast and est coast of Sweden and in July and August from resident birds in east-central Sweden were tested for neutralizing antibody to Ockelbo virus. Antibody was not detected in 328 birds sampled during spring migrations. Two of 58 (3.4%) birds bled in July and 8 of 78 birds (10%) bled in August had antibody to Ockelbo virus. Ockelbo virus circulates in a mosquito-bird-mosquito cycle, with Cs. morsitans and Cx. pipiens and/or Cx. torrentium as enzootic vectors. Antibody was detected in passerine birds. Other classes of birds or other vertebrates were not sampled. Aedes cinereus may serve primarily to transmit virus to people. The role of other mosquito species as vectors for people is unknown.