RESUMEN
A method permitting measurement of finger tremor as a displacement-time curve is described, using a test system with simple amplitude calibration. The coordinates of the inversion points of the displacement-time curves were transferred through graphical input equipment to punched tape. By means of a computer program, periods and amplitudes of tremor oscillations were calculated and classified. The event frequency for each class of periods and amplitudes was determined. The actions of fenoterol-hydrobromide, ritodrin-HCl and placebo given to 10 healthy subjects by intravenous infusion in a double-blind crossover study were tested by this method. At therapeutic doses both substances raised the mean tremor amplitude to about three times the control level. At the same time, the mean period within each class of amplitudes shortened by 10--20 ms, whereas the mean periods calculated from all oscillations together did not change significantly. After the end of fenoterol-hydrobromide infusion, tremor amplitudes decreased significantly faster than those following ritodrin-HCl infusion.
Asunto(s)
Etanolaminas/efectos adversos , Fenoterol/efectos adversos , Propanolaminas/efectos adversos , Ritodrina/efectos adversos , Temblor/inducido químicamente , Computadores , Humanos , MétodosAsunto(s)
Regulación de la Temperatura Corporal , Esfuerzo Físico , Humanos , Descanso , Temperatura CutáneaRESUMEN
During experiments on thermoregulatory behavior, subjects rested or exercised completely immersed in a water bath of constant temperature. They could adjust the temperature on their backs by means of a water-perfused pillow. The difference T diff between the freely selected temperature on their backs and the water temperature was taken as output of the system of thermoregulatory behavior. Tdiff depends on deep-body and mean skin temperature but not on a non-thermal work factor. In the equation Tdiff=ao + a1Tes + a2Ts, the ratio a1/a2 is approximately 3. This is much smaller than the same ratio for the correlation between sweat rate and deep-body and mean skin temperature which is of the order of 10.