RESUMEN
The authors studied the penetration of 14C-labelled methisoprinol into ocular tissues (cornea, aqueous humour and iris) in rabbits, in which herpetic keratitis had been experimentally induced. It has been demonstrated that the methisoprinol crosses the corneal barrier. The maximum concentration of the drug in the tissues examined was measured 30 min after the instillation of the drug into the conjunctival sac, and persisted for 60 min, although at a slightly lower level.
Asunto(s)
Ojo/metabolismo , Inosina Pranobex/metabolismo , Inosina/análogos & derivados , Queratitis Dendrítica/metabolismo , Animales , Humor Acuoso/metabolismo , Córnea/metabolismo , Femenino , Inosina Pranobex/uso terapéutico , Iris/metabolismo , Queratitis Dendrítica/tratamiento farmacológico , Soluciones Oftálmicas , ConejosAsunto(s)
Hiperostosis Cortical Congénita/diagnóstico , Inmunoglobulinas/análisis , Trombocitosis/etiología , Humanos , Hiperostosis Cortical Congénita/complicaciones , Hiperostosis Cortical Congénita/diagnóstico por imagen , Hiperostosis Cortical Congénita/inmunología , Lactante , Masculino , RadiografíaAsunto(s)
Catarata/genética , Ligamiento Genético , Cromosomas Sexuales , Cromosoma X , Adolescente , Adulto , Niño , Anomalías del Ojo , Femenino , Humanos , Masculino , Persona de Mediana Edad , Linaje , Agudeza VisualRESUMEN
On the basis of the effects caused by 5-6-dihydroxytryptamine (5-6-DHT) on the serotonin nerve endings (chronic degeneration with depletion of the mediator), the eventual existence of serotoninergic fiber regulating pupillary diameter (PD) and intraocular pressure (IOP) was studied from a functional point of view. For the miotic effect found after administration of 5-6-DHT in rabbit, not accompanied by any change in the IOP, the hypothesis of a coparticipation of the serotoninergic fibers in the regulation of the PD is proposed, thus sustaining the concept that both PD and IOP respond to mechanisms of autonomous control. A phenomenon of receptorial supersensitivity to serotonin after the lesion of the nerve endings, dependent on 5-6-DHT, was also encountered.
Asunto(s)
5,6-Dihidroxitriptamina/farmacología , Pupila/efectos de los fármacos , Receptores de Serotonina/efectos de los fármacos , Animales , Femenino , Inyecciones Intravenosas , Presión Intraocular/efectos de los fármacos , Iris/inervación , Masculino , Mióticos/farmacología , ConejosAsunto(s)
Inosina Pranobex/uso terapéutico , Inosina/análogos & derivados , Queratitis Dendrítica/tratamiento farmacológico , Administración Tópica , Adolescente , Adulto , Anciano , Animales , Niño , Preescolar , Femenino , Humanos , Queratitis Dendrítica/patología , Masculino , Persona de Mediana Edad , Conejos , RecurrenciaRESUMEN
Chemical sympathectomy of the anterior segment of the eye was performed in rabbits with 6-hydroxydopamine (6-OHDA) intravitreously injected. The response of the pupillary diameter (PD) and intraocular pressure (IOP) to NE, E and Isoproterenol was determined through instillation of the drugs in the pretreated and control eyes. The results were as follows: 1) Both PD and IOP at different intervals of time from the injection show a sharp decrease in the treated eye. 2) About four weeks after the injection, the instillation of NE and E increases the PD only in the 6-OHDA pretreated eyes, while IP administration is not effective on both control and pretreated eyes. 3) The instillation of the three drugs, while decreasing IOP in the control eyes, does not modify the already low IOP in the pretreated eyes. The authors suggest the presence of a postdenervation supersensitivity affecting only the alpha receptors, since the beta stimulant IP is inactive in both treated and untreated eyes.