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The association is defined as two or more malformations with unclear relationships, which do not fit the criteria of a syndrome. This case report presents a rare finding of tubular colonic duplication in association with Mayer-Rokitansky-Küster-Hauser syndrome in an adolescent girl. The patient presented with gastrointestinal bleeding and abdominal pain, necessitating surgical intervention. The successful excision of the duplicated segment highlights the importance of prompt diagnosis and treatment in such cases.

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A central goal of research into language acquisition is explaining how, when learners generalize to new cases, they appropriately restrict their generalizations (e.g., to avoid producing ungrammatical utterances such as *the clown laughed the man; "*" indicates an ungrammatical form). The past 30 years have seen an unresolved debate between statistical preemption and entrenchment as explanations. Under preemption, the use of a verb in a particular construction (e.g., *the clown laughed the man) is probabilistically blocked by hearing that other verb constructions with similar meanings only (e.g., the clown made the man laugh). Under entrenchment, such errors (e.g., *the clown laughed the man) are probabilistically blocked by hearing any utterance that includes the relevant verb (e.g., by the clown made the man laugh and the man laughed). Across five artificial-language-learning studies, we designed a training regime such that learners received evidence for the (by the relevant hypothesis) ungrammaticality of a particular unattested verb/noun + particle combination (e.g., *chila + kem; *squeako + kem) via either preemption only or entrenchment only. Across all five studies, participants in the preemption condition (as per our preregistered prediction) rated unattested verb/noun + particle combinations as less acceptable for restricted verbs/nouns, which appeared during training, than for unrestricted, novel-at-test verbs/nouns, which did not appear during training, that is, strong evidence for preemption. Participants in the entrenchment condition showed no evidence for such an effect (and in 3/5 experiments, positive evidence for the null). We conclude that a successful model of learning linguistic restrictions must instantiate competition between different forms only where they express the same (or similar) meanings. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

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Background: A question that lies at the very heart of language acquisition research is how children learn semi-regular systems with exceptions (e.g., the English plural rule that yields cats, dogs, etc, with exceptions feet and men). We investigated this question for Hindi ergative ne marking; another semi-regular but exception-filled system. Generally, in the past tense, the subject of two-participant transitive verbs (e.g., Ram broke the cup) is marked with ne, but there are exceptions. How, then, do children learn when ne marking is required, when it is optional, and when it is ungrammatical? Methods: We conducted two studies using (a) acceptability judgment and (b) elicited production methods with children (aged 4-5, 5-6 and 9-10 years) and adults. Results: All age groups showed effects of statistical preemption: the greater the frequency with which a particular verb appears with versus without ne marking on the subject - relative to other verbs - the greater the extent to which participants (a) accepted and (b) produced ne over zero-marked subjects. Both children and adults also showed effects of clause-level semantics, showing greater acceptance of ne over zero-marked subjects for intentional than unintentional actions. Some evidence of semantic effects at the level of the verb was observed in the elicited production task for children and the judgment task for adults. Conclusions: participants mainly learn ergative marking on an input-based verb-by-verb basis (i.e., via statistical preemption; verb-level semantics), but are also sensitive to clause-level semantic considerations (i.e., the intentionality of the action). These findings add to a growing body of work which suggests that children learn semi-regular, exception-filled systems using both statistics and semantics.

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Context: Automated detection of COVID-19 in real time can greatly help clinicians to handle increasing number of cases for preliminary screening. Deep CNN models trained with sufficiently large datasets may become best candidates to meet the purpose. Aims: This study aims for automated detection and classification of COVID-19 and viral pneumonia diseases by applying deep CNN model using chest X-ray images. The proposed model performs multiclass classification to meet the purpose. Settings and Design: The proposed model is built on top of VGG16 architecture with pretrained ImageNet weights. The model was fine-tuned using additional custom layers to deliver better performance specific to the target. Subjects and Methods: A total of 15,153 samples are used in this work. These samples include chest X-ray images of COVID-19, viral pneumonia, and normal cases. The entire dataset was split into train and test sets, with a ratio of 80:20 before training the model. To enhance important image features, image preprocessing and augmentation were applied before feeding the image batches to the model. Statistical Analysis Used: Performance of the model is evaluated through accuracy, precision, recall, and F1 score performance metrics. The results produced by the model are also compared with other recent leading studies. Results: The proposed model has achieved a classification accuracy of 98% with 98% precision, 96% recall, and 97% F1 score on the test dataset for multiclass classification. The area under receiver operating characteristic curve score was 0.99 for all three cases of multiclass classification. Conclusions: The proposed classification model may be highly useful for the preliminary diagnosis of COVID-19 and viral pneumonia cases, especially during heavy workloads and large quantities.

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The present study aimed at understanding the subjective perception of happiness in a sample of Indian participants from diverse socio-economic backgrounds. Using convenience sampling, individual interviews were conducted with 60 participants aged between 19 to 73 years (M Age = 40 years). This study employed reflexive thematic analysis to analyse the written transcripts. Nine themes were generated which captured the essence of happiness for Indians-Feelings and Expressions of Happiness; Human Ties and Happiness which encompassed four sub-themes-family bond, the company one keeps, the pandemic and social disengagement, and the nation, society and happiness; Satisfaction with Material Needs and Resources; Lifestyle and Health; Work and Play; Accomplishment and Appreciation; Nature Connectedness; Religious and Spiritual beliefs; and Happiness as a Personal responsibility-Role of Positive Personality Traits. These findings revealed our respondent's multidimensional conceptualization of happiness, and adds to the growing body of happiness literature from the South Asian context.

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Environmental contamination due to heavy metals (HMs) is of serious ecotoxicological concern worldwide because of their increasing use at industries. Due to non-biodegradable and persistent nature, HMs cause serious soil/water pollution and severe health hazards in living beings upon exposure. HMs can be genotoxic, carcinogenic, mutagenic, and teratogenic in nature even at low concentration. They may also act as endocrine disruptors and induce developmental as well as neurological disorders, and thus, their removal from our natural environment is crucial for the rehabilitation of contaminated sites. To cope with HM pollution, phytoremediation has emerged as a low-cost and eco-sustainable solution to conventional physicochemical cleanup methods that require high capital investment and labor alter soil properties and disturb soil microflora. Phytoremediation is a green technology wherein plants and associated microbes are used to remediate HM-contaminated sites to safeguard the environment and protect public health. Hence, in view of the above, the present paper aims to examine the feasibility of phytoremediation as a sustainable remediation technology for the management of metal-contaminated sites. Therefore, this paper provides an in-depth review on both the conventional and novel phytoremediation approaches; evaluates their efficacy to remove toxic metals from our natural environment; explores current scientific progresses, field experiences, and sustainability issues; and revises world over trends in phytoremediation research for its wider recognition and public acceptance as a sustainable remediation technology for the management of contaminated sites in the twenty-first century.

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INTRODUCTION: Disorders of mineral and bone metabolism in chronic kidney disease (CKD) are associated with increased risk for cardiovascular calcification and osteoporosis. Anemia has been associated with progressive loss of kidney function and increased mortality. Ferric citrate was recently developed, primarily as a novel oral, non-calcium phosphate binder, which has also shown to replenish the iron deficient state of the CKD patients. MATERIAL AND METHODS: This prospective study was done on 40 pre-dialysis adult patients of CKD (stage 3-5) from a tertiary care centre in North India. Patients on intravenous iron, erythropoietin stimulating agents or other phosphate binders were excluded from the study. All the patients were given tablet ferric citrate (each tablet containing ferric citrate 1.1 gm equivalent to ferric iron 210 mg) in a dose of 3 tablets per day for three months. Patients were followed up at two weekly intervals and relevant investigations were done. They were divided into three groups according to their CKD stages for subgroup analysis. OBSERVATIONS: After three months of therapy with ferric citrate there was a significant decrease in mean serum phosphate from 6.55±0.70 mg/dl at baseline to 4.36±0.50 mg/dl at the end of three months (p<0.001). Mean hemoglobin increased from 7.92±1.05 g/dl at baseline to 10.96±1.04 g/dl at the end of three months (p<0.001). Serum ferritin and serum transferrin saturation increased from 278.25±110.56 ng/dl, 25.02±4.03 % at baseline to 401.24±152.47 ng/dl and 29.62±3.77 % at the end of three months. The mean serum vitamin D and serum iPTH levels, at baseline and at the end of 3 months were 14.61±10.80 ng/ml, 509.48±210.75 pg/ml and 23.65±14.00 ng/ml, 424.14±173.18 pg/ml respectively. The change in all these parameters were significant irrespective of the CKD stages. CONCLUSION: The present study has shown that ferric citrate is an effective and well tolerated phosphate binder, which also significantly improves hematologic parameters in an iron deficient CKD patient.

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Tannery wastewater (TWW) is of serious environmental concern to pollution control authorities, because it contains highly toxic, recalcitrant organic and inorganic pollutants. The nature and characteristics of recalcitrant organic pollutants (ROPs) are not fully explored to date. Hence, the purpose of this study was to characterize and identify the ROPs present in the treated TWW. Gas chromatography-mass spectrometry data analysis showed the presence of a variety of ROPs in the treated TWW. Results unfolded that benzyl chloride, butyl octyl phthalate, 2,6-dihydroxybenzoic acid 3TMS, dibutyl phthalate, benzyl alcohol, benzyl butyl phthalate, 4-chloro-3-methyl phenol, phthalic acid, 2'6'-dihydroxyacetophenone, diisobutyl phthalate, 4-biphenyltrimethylsiloxane, di-(-2ethy hexyl)phthalate, 1,2-benzenedicarboxylic acid, dibenzyl phthalate, and nonylphenol were present in the treated TWW. Due to endocrine disrupting nature and aquatic toxicity, the U.S. Environmental Protection Agency classified many of these as "priority pollutants" and restricted their use in leather industries. In addition, the physicochemical analysis of the treated TWW also showed very high BOD, COD, and TDS values along with high Cr and Pb content beyond the permissible limits for industrial discharge. Furthermore, phytotoxicity assessment unfolds the inhibitory effects of TWW on the seed germination, seedling growth parameters, and α-amylase activity in Phaseolus aureus L. This indicates that the TWW discharged even after secondary treatment into the environment has very high pollution parameters and may cause a variety of serious health threats in living beings upon exposure. Overall, the results reported in this study will be helpful for the proper treatment and management of TWW to combat the environmental threats.

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Leather industries are key contributors in the economy of many developing countries, but unfortunately they are facing serious challenges from the public and governments due to the associated environmental pollution. There is a public outcry against the industry due to the discharge of potentially toxic wastewater having alkaline pH, dark brown colour, unpleasant odour, high biological and chemical oxygen demand, total dissolved solids and a mixture of organic and inorganic pollutants. Various environment protection agencies have prioritized several chemicals as hazardous and restricted their use in leather processing however; many of these chemicals are used and discharged in wastewater. Therefore, it is imperative to adequately treat/detoxify the tannery wastewater for environmental safety. This paper provides a detail review on the environmental pollution and toxicity profile of tannery wastewater and chemicals. Furthermore, the status and advances in the existing treatment approaches used for the treatment and/or detoxification of tannery wastewater at both laboratory and pilot/industrial scale have been reviewed. In addition, the emerging treatment approaches alone or in combination with biological treatment approaches have also been considered. Moreover, the limitations of existing and emerging treatment approaches have been summarized and potential areas for further investigations have been discussed. In addition, the clean technologies for waste minimization, control and management are also discussed. Finally, the international legislation scenario on discharge limits for tannery wastewater and chemicals has also been discussed country wise with discharge standards for pollution prevention due to tannery wastewater.

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Thermal inactivation of normal and starved cells of Salmonella Enteritidis on chicken skin previously exposed to different concentrations of acidified sodium chlorite (ASC) or tri-sodium phosphate (TSP) was investigated. Inoculated skin was pretreated with different concentration of ASC or TSP, packaged in bags, and then immersed in a circulating water bath at 60 to 68 °C. The recovery medium was Hektoen enteric agar. D-values, determined by linear regression, for normal cells on chicken skin, were 2.79, 1.17 and 0.53 min whereas D-values for starved cells were 4.15, 1.83 and 0.66 at 60, 64 and 68 °C, respectively. z-values for normal cells were 3.54 and for starved cells were 2.29. Pretreatment of Salmonella Enteritidis cells with 0 to 200 ppm of ASC or 0 to 1.0 % TSP resulted in lower D-values at all temperatures. Sensory results indicated no significance differences for control and treatments. Thus, results of this study indicated that pretreatment of chicken skin with ASC or TSP increased sensitivity of Salmonella Enteritidis to heat without affecting organoleptic quality of chicken meat.

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Water is critical for life, but many people do not have access to clean and safe drinking water and die because of waterborne diseases. The analysis of drinking water for the presence of indicator microorganisms is key to determining microbiological quality and public health safety. However, drinking water-related illness outbreaks are still occurring worldwide. Moreover, different indicator microorganisms are being used in different countries as a tool for the microbiological examination of drinking water. Therefore, it becomes very important to understand the potentials and limitations of indicator microorganisms before implementing the guidelines and regulations designed by various regulatory agencies. This review provides updated information on traditional and alternative indicator microorganisms with merits and demerits in view of their role in managing the waterborne health risks as well as conventional and molecular methods proposed for monitoring of indicator and pathogenic microorganisms in the water environment. Further, the World Health Organization (WHO) water safety plan is emphasized in order to develop the better approaches designed to meet the requirements of safe drinking water supply for all mankind, which is one of the major challenges of the 21st century.

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