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Background: Stroke is ischemia and neurological dysfunction caused by acute brain circulation loss. It causes acute localized neurological abnormalities such as weakness, sensory deficit, or language issues that require long-term treatment. These deficiencies harm the patient and their family psychologically, socially, and economically. Thus, combination treatment can rapidly rehabilitate such patients. Detoxification methods like Ayurvedic medicated enema help stroke pathophysiology. Physical modalities in physiotherapy have been shown to facilitate normal movement and function on the stroke patient's affected side, increasing independence with everyday duties. A stroke patient may benefit from Dashmoola Niruha Basti, Function Electrical Stimulation (FES), and Motor Relearning Programme (MRP). Aim & Objectives: This study compares the adjuvant role of Dashmoola Basti with MRP and FES in stroke recovery. The main goals of this study are to assess and compare the adjuvant role of Dashmoola Basti with standard control over sensorimotor function of lower extremities, static and dynamic balance in stroke patients; gait parameters; resistance experienced during passive range of motion; quality of life of patients; Barthel Index; Modified Ashworth Scale; and Fuglmeyer assessment, Single Limb Stance Test, Functional Reach Test. Methods: A total of 40 patients will be enrolled and divided randomly into two equal groups. In Group A (control), standard treatment (modern + physiotherapy) will be prescribed for one month. In Group B (interventional group), Dashmoola Basti will be added to the aforementioned standard treatment for one month. Expected results: Improvement in Fuglmeyer assessment, Single Limb Stance Test, Functional Reach Test, quality of Life of Patients, Barthel Index, Modified Ashworth scale, and National Institute of Health (NIH) stroke-scale-score will be observed and recorded. Conclusions: Results and conclusions will be derived according to the data collected in case record form and assessment sheets filled at baseline and follow-up visits. Trial registration: CTRI/2021/10/037445 dated 21.10.2021.

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Research and development improvements in early cancer diagnosis have had a significant positive impact on health. In the treatment and prevention of cancer, early detection is essential. In this context, biomarkers are essential because they offer important information on the state of cells at any particular time. Cells go through unique changes when they shift from a healthy condition to a malignant state, changes that appropriate biomarkers may pick up. Recent advancements have been made to identify and characterize circulating cancer-specific mutations in cell-free circulating DNA derived from tumors and tumor cells. A patient's delay between the time they first detect symptoms and the time they contact a doctor has been noted for many cancer forms. The tumor's location and features significantly impact the presentation of symptoms judged appropriate for early diagnosis. Lack of knowledge of the severity of the symptoms may be one cause for this delay. Our review is largely focused on the ongoing developments of early diagnosis in the study of biomarkers, circulating DNA for diagnosis, the biology of early challenges, early symptoms, liquid biopsies, detectable by imaging, established tumor markers, plasma DNA technologies, gender differences, and artificial intelligence (AI) in diagnosis. This review aims to determine and evaluate Indicators for detecting early cancer, assessing medical conditions, and evaluating potential risks. For Individuals with a heightened likelihood of developing cancer or who have already been diagnosed, early identification is crucial for enhancing prognosis and raising the likelihood of effective treatment.

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INTRODUCTION: The recent pandemic of COVID-19 is very challenging for each and every sector like health, economic, technology, agriculture, industries, and education. In the field of education, a teaching institute or a university is suffering in regard to syllabus completion, clinical postings, and examinations which eventually ends up in huge academic loss. Thus, to minimize the academic loss and facilitate the students in distance education, online learning was the solution; in spite of various challenges, Datta Meghe Institute of Medical Sciences (Deemed to be University) have implemented the online learning program for the undergraduate students within a week of lockdown. METHODOLOGY: The survey was conducted at MGACH&RC, total of 189 students have participated in the survey. Data collected by survey with help of feedback on a 5-point Likert scale questionnaire with close- and open-ended questions and focus group discussion (FGD) with students. DISCUSSION: Although the program was implemented to verify the utility, accomplishment, and lacunas of e-learning, the survey was planned to assess the perception of students toward online learning during the COVID-19 pandemic. The e-learning model has been successfully introduced; there are more requirements from the students regarding the resource material and minimal lacunas regarding the skill of faculty members and technical issues. Students appreciate the online learning module for the pandemic situation and necessitated for the combination of both learning modalities in future. Seamlessly, the running program recommended online assessment and evaluation of the students in future.