RESUMEN
The authors have examined the activities of the enzymes GOT, CPT, CK, LDH, gamma-GT, PCHE and ALP in the cerebrospinal fluid of 50 patients with various neurological diseases. The results obtained show that many activities constantly and remarkably increase in few diseases of the nervous system. Particularly, GOT, GPT, LDH and ALP demonstrated raised values in the meningitis; LDH, CK, GOT, GPT in the brain tumors; CK and LDH in the hydrocephalus. A comparison between the results of the protein and enzyme determinations in the cerebrospinal fluid of the same patients, revealed in the enzymologic reactions a more precocious and sensitive indicator of initial brain lesions.
Asunto(s)
Enzimas/líquido cefalorraquídeo , Enfermedades del Sistema Nervioso/enzimología , Adolescente , Adulto , Anciano , Alanina Transaminasa/líquido cefalorraquídeo , Fosfatasa Alcalina/líquido cefalorraquídeo , Aspartato Aminotransferasas/líquido cefalorraquídeo , Niño , Preescolar , Colinesterasas/líquido cefalorraquídeo , Creatina Quinasa/líquido cefalorraquídeo , Femenino , Humanos , L-Lactato Deshidrogenasa/líquido cefalorraquídeo , Masculino , Persona de Mediana Edad , gamma-Glutamiltransferasa/líquido cefalorraquídeoRESUMEN
The authors studied the behaviour of a few cerebrospinal fluid enzymes (GOT, GPT, LDH, ALP, CK, gamma-GT, PCHE) obtained from 26 patients without neurologic diseases. The stability of the enzymes has been verified in experimental various conditions, after store of the samples at different times and temperatures. This research has been carried in order to contribute to the determination of the reference values and to relieve their possible alterations.