RESUMEN
Experiments on albino rats showed that pyrimidine derivatives reduce hemorrhagic damage of the gastric mucosa caused by indomethacin, acetylsalicylic acid, and ortophen. The derivatives of pyrimidine prevent the decrease in total acid phosphatase activity, increase alkaline phosphatase, and reduce the activity of lactate dehydrogenase.
Asunto(s)
Antiulcerosos/uso terapéutico , Pentoxil (Uracilo)/análogos & derivados , Pirimidinas/uso terapéutico , Úlcera Gástrica/tratamiento farmacológico , Uracilo/análogos & derivados , Animales , Antiinflamatorios no Esteroideos , Aspirina , Diclofenaco , Modelos Animales de Enfermedad , Evaluación Preclínica de Medicamentos , Indometacina , Pentoxil (Uracilo)/uso terapéutico , Ratas , Úlcera Gástrica/inducido químicamente , Uracilo/uso terapéuticoRESUMEN
Pyrimidine derivatives increased the antibiotic therapy efficacy in albino rats irradiated with RUM-7 apparatus for close-focus roentgenotherapy. 2-Methyl-4-amino-6-oxypyrimidine was twice as efficient as oxymethyluracil and 6 times as efficient as methyluracil in the stimulation of the skin reparative regeneration. When the total irradiation was performed with LUCH-1 apparatus in a dose of 6 Gy the pyrimidine derivatives also increased the antibiotic therapy efficacy. After the prophylactic use of the pyrimidine derivatives for 7 days prior to the total irradiation their therapeutic effect increased, the level of the exudative component lowered, the tissue epithelization increased, the terms of the wound healing decreased and the animal lifespan increased.