RESUMEN

Using positron-emission tomography (PET), we found that cold-induced glucose uptake was increased by a factor of 15 in paracervical and supraclavicular adipose tissue in five healthy subjects. We obtained biopsy specimens of this tissue from the first three consecutive subjects and documented messenger RNA (mRNA) and protein levels of the brown-adipocyte marker, uncoupling protein 1 (UCP1). Together with morphologic assessment, which showed numerous multilocular, intracellular lipid droplets, and with the results of biochemical analysis, these findings document the presence of substantial amounts of metabolically active brown adipose tissue in healthy adult humans.

Asunto(s)

Tejido Adiposo Pardo/metabolismo , Metabolismo Energético , Fluorodesoxiglucosa F18/farmacocinética , Radiofármacos/farmacocinética , Adipocitos Marrones/metabolismo , Tejido Adiposo Pardo/citología , Adiposidad , Adulto , Biopsia , Frío , Expresión Génica , Marcadores Genéticos/fisiología , Humanos , Canales Iónicos/genética , Canales Iónicos/metabolismo , Masculino , Persona de Mediana Edad , Proteínas Mitocondriales/genética , Proteínas Mitocondriales/metabolismo , Tomografía de Emisión de Positrones , ARN Mensajero/metabolismo , Proteína Desacopladora 1 , Regulación hacia Arriba