RESUMEN

D-Cysteinolic acid (1) analogues with an S-C-C-N skeleton showed increased platelet anti-aggregant activity in the following order: 2-aminoethanesulfonic acids, thiazolidines, 2-aminoethanethiols and 2-aminoethyl disulfides. Methyl substitutions at the 2-position potentiated the activity. Of these analogues, bis [(R)-2-aminopropyl] disulfide was the most potent inhibitor of platelet aggregation, with about 600-fold the activity of (1).

Asunto(s)

Cisteína/análogos & derivados , Inhibidores de Agregación Plaquetaria , Animales , Cisteína/farmacología , Disulfuros/farmacología , Masculino , Estructura Molecular , Ratas , Ratas Endogámicas , Relación Estructura-Actividad , Compuestos de Sulfhidrilo/farmacología