Asunto(s)
Antipsicóticos/farmacología , Aripiprazol/farmacología , Trastornos Relacionados con Cocaína/prevención & control , Cocaína/toxicidad , Modelos Animales de Enfermedad , Fumarato de Quetiapina/farmacología , Convulsiones/prevención & control , Anestésicos Locales/toxicidad , Animales , Trastornos Relacionados con Cocaína/etiología , Trastornos Relacionados con Cocaína/mortalidad , Ratones , Ratones Endogámicos BALB C , Convulsiones/inducido químicamente , Convulsiones/mortalidad , Tasa de SupervivenciaRESUMEN
INTRODUCTION: Musculoskeletal system traumas are among the most common presentations in the emergency departments. In the treatment of traumatic musculoskeletal pain, paracetamol and non-steroidal anti-inflammatory analgesics (NSAID) are frequently used. Our aim in this study is to compare the efficacy of intravenous dexketoprofen and paracetamol in the treatment of traumatic musculoskeletal pain. METHODS: This prospective, randomised, double blind, controlled study was conducted in a tertiary care emergency unit. The participating patients were randomised into two groups to receive either 50â¯mg of dexketoprofen or 1000â¯mg of paracetamol intravenously by rapid infusion in 150â¯mL of normal saline. Visual analogue scale (VAS), Numeric Rating Scala (NRS) and Verbal Rating Scale (VRS) was employed for pain measurement at baseline, after 15, after 30 and after 60â¯mins. RESULTS: 200 patients were included in the final analysis. The median age of the paracetamol group was 34 (24-48), while that of the dexketoprofen group was 35 (23-50), and 63% (nâ¯=â¯126) of them consisted of men. Paracetamol and dexketoprofen administration reduced VAS pain scores over time (pâ¯=â¯0.0001). Median reduction in VAS score at 60â¯min was 55 (IQR 30-65) for the paracetamol group and 50(IQR 30.25-60) for the dexketoprofen group. There was no statistically significant difference between the paracetamol and dexketoprofen groups in terms of VAS reductions (pâ¯=â¯0.613). CONCLUSION: Intravenous paracetamol and dexketoprofen seem to produce equivalent pain relief for acute musculoskeletal trauma in the emergency department. CLINICALTRIALS. GOV NO: NCT03428503.