RESUMEN
Along with several social institutions, the family has its unique place as the foundation of a strong state. For this reason, family problems are at the center of research in modern psychological science aimed at identifying key factors of health, well-being and a prosperous life in the family. The purpose of this work is to identify the ability of spouses to cope with family difficulties or conflict situations and to study their correspondence to the manifestations of a person's emotional intelligence as a guarantee of satisfaction and family health. At different stages of its development the family very often faces problems, for which the spouses use a conscious toolkit. Emotional intelligence, being one of the fundamental components of personality, influences the choice of a person's coping strategy in conflict situations: Studies have shown that a person's high levels of emotional intelligence (EQ or EI) have a reciprocal relationship with coping, a rational problem-solving orientation. It also leads to personal satisfaction, creating the basis for family well-being and a healthy psychological atmosphere. We can conclude that the higher a person's perception and recognition of his own and others' emotions, emotional states, the easier and faster he distinguishes between his own and others' emotional manifestations and expressions, and of course is able to freely manage them, the more a person is able to show organization when facing various difficulties, the better he can regulate actions, as well as control the current situation. As a result, the person experiences satisfaction with family life.
Asunto(s)
Adaptación Psicológica , Inteligencia Emocional , Conflicto Familiar , Esposos , Humanos , Esposos/psicología , Masculino , Femenino , Conflicto Familiar/psicología , Adulto , Satisfacción Personal , Persona de Mediana EdadRESUMEN
In obesity fasting levels of both glucagon and insulin are elevated. In these subjects fasting levels of the free fatty acid palmitate are raised. We have demonstrated that palmitate enhances glucose-stimulated insulin secretion from isolated human islets via free fatty acid receptor 1 (FFAR1/GPR40). Since FFAR1 is also present on glucagon-secreting alpha-cells, we hypothesized that palmitate simultaneously stimulates secretion of glucagon and insulin at fasting glucose concentrations. In addition, we hypothesized that concomitant hypersecretion of glucagon and insulin was also contributed by reduced somatostatin secretion. We found basal glucagon, insulin and somatostatin secretion and respiration from human islets, to be enhanced during palmitate treatment at normoglycemia. Secretion of all hormones and mitochondrial respiration were lowered when FFAR1 or fatty acid ß-oxidation was inhibited. The findings were confirmed in the human beta-cell line EndoC-ßH1. We conclude that fatty acids enhance both glucagon and insulin secretion at fasting glucose concentrations and that FFAR1 and enhanced mitochondrial metabolism but not lowered somatostatin secretion are crucial in this effect. The ability of chronically elevated palmitate levels to simultaneously increase basal secretion of glucagon and insulin positions elevated levels of fatty acids as potential triggering factors for the development of obesity and impaired glucose control.
Asunto(s)
Glucagón/metabolismo , Insulina/metabolismo , Islotes Pancreáticos/metabolismo , Palmitatos/farmacología , Receptores Acoplados a Proteínas G/metabolismo , Somatostatina/metabolismo , Línea Celular , Ácidos Grasos/metabolismo , Células Secretoras de Glucagón/citología , Células Secretoras de Glucagón/efectos de los fármacos , Células Secretoras de Glucagón/metabolismo , Glucosa/metabolismo , Humanos , Islotes Pancreáticos/citología , Islotes Pancreáticos/efectos de los fármacos , Mitocondrias/fisiologíaRESUMEN
The MedAustron Ion therapy center will be constructed in Wiener Neustadt (Austria) in the vicinity of Vienna. Its accelerator complex consists of four ion sources, a linear accelerator, a synchrotron, and a beam delivery system to the three medical treatment rooms and to the research irradiation room. The ion sources shall deliver beams of H(3)(1+), C(4+), and light ions with utmost reliability and stability. This paper describes the features of the ion sources presently planned for the MedAustron facility, such as ion source main parameters, gas injection, temperature control, and cooling systems. A dedicated beam diagnostics technique is proposed in order to characterize electron cyclotron resonance (ECR) ion beams; in the first drift region after the ion source, a fraction of the mixed beam is selected via moveable aperture. With standard beam diagnostics, we then aim to produce position-dependant observables such as ion-current density, beam energy distribution, and emittance for each charge states to be compared to simulations of ECR e-heating, plasma simulation, beam formation, and transport.
Asunto(s)
Radioterapia/instrumentación , Carbono , Luz , Fenómenos Mecánicos , Modelos Teóricos , Protones , Radioterapia/métodos , Reproducibilidad de los Resultados , TemperaturaRESUMEN
The unfolded protein response (UPR) is an intracellular signaling pathway that regulates the protein folding and processing capacity of the endoplasmic reticulum (ER). The UPR is induced by the pharmacological agents that perturb ER functions but is also activated upon excessive accumulation of the mutant secretory proteins that are unable to attain correct three-dimensional structure and are thus retained in the ER. Such defects in intracellular protein transport underlie the development of a number of phenotypically diverse inherited pathologies, termed endoplasmic reticulum storage diseases (ERSD). We have studied UPR development in two similar ERSDs, human congenital goiter caused by the C1264R and C1996S mutations in the thyroglobulin (Tg) gene and non-goitrous congenital hypothyroidism in rdw dwarf rats determined by the G2320R Tg mutation. In both cases, these mutations rendered Tg incapable of leaving the ER. A major ER chaperone immunoglobulin-binding protein (BiP), and a novel putative escort chaperone endoplasmic reticulum protein 29 KDa (ERp29) were found to be associated with Tg, which might be interpreted as the contribution of the quality control machinery to the previously shown retention of Tg in the ER. We have extended our earlier observations of ER chaperone induction with the identification of the additional ER (ERp29, ERp72, calreticulin, protein disulfide isomerase (PDI)), cytoplasmic (heat shock protein (HSP)70, HSP90) and mitochondrial (mtHSP70) upregulated chaperones and folding enzymes. Activation of the transcriptional arm of UPR, as judged by the appearance of the spliced (active) form of X-box binding protein (XBP1) and processed activating transcription factor 6 (ATF6) transcription factors was suggested to contribute to the overexpression of the ER chaperones. The processing of ATF6 was observed in both human and rat tissues with Tg mutations. Whereas, in human tissues, weak splicing of XBP1 mRNA was detected only in the C1264R mutant, all rat thyroids including wild-type contained significant amounts of the spliced form of XBP1 as opposed to human liver and rat brain tissues, implying the existence of a previously unknown tissue-specific regulation of XBP1 processing.