RESUMEN

Medication errors may occur at any point during patient care in the health care system. Drug interaction in known with macrolide antibiotics and ranolazine and is primarily related to effects on the cytochrome P4503A (CYP3A) metabolic pathway. This case highlights medication errors that resulted in rare debilitating neurological adverse effects of ranolazine in an elderly due to drug interaction with clarithromycin.

Asunto(s)

Acetanilidas/efectos adversos , Claritromicina/efectos adversos , Síndromes de Neurotoxicidad/etiología , Piperazinas/efectos adversos , Acetanilidas/administración & dosificación , Anciano , Antibacterianos/administración & dosificación , Antibacterianos/efectos adversos , Claritromicina/administración & dosificación , Inhibidores del Citocromo P-450 CYP3A/administración & dosificación , Inhibidores del Citocromo P-450 CYP3A/efectos adversos , Interacciones Farmacológicas , Inhibidores Enzimáticos/administración & dosificación , Inhibidores Enzimáticos/efectos adversos , Humanos , Masculino , Errores de Medicación , Síndromes de Neurotoxicidad/fisiopatología , Piperazinas/administración & dosificación , Ranolazina

RESUMEN

Hyperkalemic paralysis due to Addison's disease is rare, and potentially life-threatening entity presenting with flaccid motor weakness. This case under discussion highlights Hyperkalemic paralysis as initial symptomatic manifestation of primary adrenal insufficiency.