Asunto(s)
Trasplante de Médula Ósea , Movilización de Célula Madre Hematopoyética , Trasplante de Células Madre Hematopoyéticas , Argentina , Movilización de Célula Madre Hematopoyética/métodos , Movilización de Célula Madre Hematopoyética/normas , Humanos , Estudios Multicéntricos como Asunto , Encuestas y CuestionariosRESUMEN
OBJECTIVE: To evaluate in a multivariate analysis the prognostic factors associated with hematopoietic recovery and the supportive care requirements after autotransplant of progenitor cells (PC) from various sources: bone marrow (BMPC), BMPC & peripheral blood (PBPC), and PBPC alone. PATIENTS AND METHODS: A total of 570 patients with hematological malignancies and solid tumors underwent high-dose therapy followed by autotransplant. PBPC were obtained after mobilization with chemotherapy and/or cytokines. One-hundred five patients received BMPC, 217 received BMPC & PBPC and 248 PBPC alone; all of the patients received G-CSF or GM-CSF after infusion. RESULTS: In a multivariate analysis the recovery of neutrophils was adversely associated with low numbers of nucleated cells infused (P < 0.13), bone marrow progenitor cell source, and diagnosis of multiple myeloma and acute leukemia (P < 0.001). The factors that adversely affected platelet recovery were low number of nucleated cells and diagnosis of multiple myeloma and acute leukemia (P < 0.001). CONCLUSIONS: We conclude that BMPC adversely affect neutrophil recovery while low numbers of nucleated cells and diagnosis of multiple myeloma and acute leukemia adversely affect both neutrophil and platelet recovery.
Asunto(s)
Trasplante de Médula Ósea , Células Precursoras Eritroides , Neoplasias Hematológicas/terapia , Trasplante de Células Madre Hematopoyéticas , Adolescente , Adulto , Anciano , Trasplante de Médula Ósea/métodos , Niño , Preescolar , Supervivencia sin Enfermedad , Estudios de Evaluación como Asunto , Femenino , Supervivencia de Injerto , Neoplasias Hematológicas/diagnóstico , Neoplasias Hematológicas/fisiopatología , Humanos , Masculino , Persona de Mediana Edad , Análisis Multivariante , Pronóstico , Análisis de Regresión , Estudios Retrospectivos , Tasa de Supervivencia , Trasplante AutólogoRESUMEN
As part of our investigations on fluorine containing compounds of potential pharmacological interest, a series of N-substituted p-fluorobenzencarboxyamides, analogs of previously studied p-fluorobenzensolfonamides, was prepared. The in vitro antibacterial and antimycotic properties were also assayed. The replacement of the sulfonamide group with an isosteric carboxyamide one, was found to confer to trifluoromethylsubstituted compounds good activity against some strains of yeasts (Candida) and hyphomycetes (Tricophyton, Aspergillus, Microsporum, Epidermophyton). These compounds however are not very active against the gram-positive and gram-negative bacteria on which the corresponding sulfonanilides showed significant activity.
Asunto(s)
Antiinfecciosos/síntesis química , Bacterias/efectos de los fármacos , Fluorobencenos/síntesis química , Hongos/efectos de los fármacos , Antibacterianos , Antifúngicos/síntesis química , Benzamidas/síntesis química , Benzamidas/farmacología , Fenómenos Químicos , Química , Fluorobencenos/farmacología , Pruebas de Sensibilidad MicrobianaRESUMEN
Further pharmacological (antipyretic and analgesic activities) and physicochemical (pka and relative lipophilicity) studies are reported on some trifluoroacetanilides which have preliminary revealed promising activities in the animal models of acute and chronic inflammation, in analogy with the known antiinflammatory trifluoromethanesulfonanilides.
Asunto(s)
Acetanilidas/síntesis química , Analgésicos/síntesis química , Antiinflamatorios no Esteroideos/síntesis química , Antiinflamatorios/síntesis química , Acetanilidas/farmacología , Animales , Fenómenos Químicos , Química Física , Flúor/síntesis química , Flúor/farmacología , Concentración de Iones de Hidrógeno , Lípidos , Masculino , Ratones , Ratas , SolubilidadRESUMEN
In an extension of the investigations on fluorine derivatives of potential pharmacological interest, some new p-fluorobenzensulfonanilides were synthesized and screened in vitro against many species of Gram-positive and Gram-negative bacteria and against some strains of Candida albicans. Some of these compounds exhibited significant antibacterial activity. The relation between activity and structure revealed that the presence of chloro and trifluoromethyl groups in the aniline ring increases activity against Gram-positive bacteria. The acute toxicity in mice was also determined.
Asunto(s)
Antiinfecciosos/síntesis química , Fluorobencenos/síntesis química , Sulfonamidas/síntesis química , Animales , Antibacterianos , Candida albicans/efectos de los fármacos , Fenómenos Químicos , Química , Femenino , Fluorobencenos/farmacología , Bacterias Gramnegativas/efectos de los fármacos , Bacterias Grampositivas/efectos de los fármacos , Dosificación Letal Mediana , Masculino , Ratones , Pruebas de Sensibilidad Microbiana , Sulfonamidas/farmacologíaRESUMEN
The analogy with the anti-inflammatory trifluoromethane-sulfonanilides prompted us to the synthesis of a series of trifluoroacetanilides which were found to maintain the pharmacological properties of the analog sulfonanilides. Many of the obtained compounds inhibited either the carrageenin-induced rat paw edema and the adjuvant-induced arthritis; some showed better anti-inflammatory properties than indomethacin and phenylbutazone. Acute toxicity and ulcerogenic effects were significantly lower than those of reference drugs.