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Primary tracheal neoplasms are uncommon and poorly documented in veterinary medicine, being most frequently reported in domestic cats. Squamous cell carcinoma (SCC) is a malignant neoplasm that originates from the stratified squamous epithelium, considered one of the most common skin neoplasms in dogs and cats. This paper aims to report the anatomopathological and immunohistochemical findings of a clinical case of primary SCC in the trachea of ​​a female Schnauzer canine, attended at the Veterinary Hospital Luiz Quintiliano de Oliveira of the Faculty of Veterinary Medicine of Araçatuba (FMVA ­ UNESP), complaining of choking, coughing and dyspnea for 1 month. The tracheal portion affected by the neoplasm was sent to the Veterinary Pathology department of the FMVA after surgical excision. Fragments of the neoplasm were collected and fixed in 10% formaldehyde for further histopathological and immunohistochemical analysis. Microscopically, the neoplasm was well differentiated, being characterized by the presence of keratin pearls, low degree of pleomorphism and rare mitotic figures. In the immunohistochemical analysis, there was immunoexpression of anti-cytokeratin antibodies AE1AE3, 34BE12, CK14 and CK5/6, confirming the diagnosis of squamous cell carcinoma. In about 30% of the cells there was immunostaining for Ki67 antibodies, justifying the low mitotic index of tumor cells and the few images of mitosis seen. Due to the rare occurrence of primary tracheal SCC in dogs, the use of diversified diagnostic techniques is important in order to better understand the biological behavior of this neoplasm in unusual anatomical locations.(AU)

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Background: Coronary artery bypass graft (CABG) surgery is associated with worsened functional capacity, pulmonary complications, and increased length of hospital stay. These negative effects are exacerbated in patients who are at high risk of post-operative (PO) pulmonary complications before CABG. Inspiratory muscle training (IMT) has been shown to benefit CABG patients in their recovery process. However, in high-risk patients, there is little evidence to support the post-operative implementation of IMT for purposes of faster recovery. Aim: The aim of the study was to test the hypothesis that IMT improves the functional capacity, pulmonary complications, and length of hospital stay in patients prone to pulmonary complications who had undergone CABG. Methods: This is a pilot clinical trial carried out with patients at high risk for pulmonary complications in the PO phase. In the pre-operative period, maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP), and 6-min walk test (6MWT) were determined and administered. On the first PO day, patients were divided into two groups: A control group (CG) that received routine intervention and an IMT group that, in addition to routine care, was subjected to an IMT protocol until hospital discharge. On the day of discharge, the patients were reassessed with respect to ventilatory muscle strength, functional capacity, PO complications, and length of stay. Results: Twenty-nine patients were evaluated, 15 in the CG and 14 in the IMT group. No significant differences were observed in relation to MIP (difference between the mean of -7 cmH2O; 95% CI = -16.52-2.52), MEP (difference between the mean of -7cm H2O; 95% CI = -15.39-1.39), and in the 6MWT (difference between the mean of -9 m; 95% CI = -43.71-25.71). There was a decrease in the length of stay in the IMT group compared to the CG (9 ± 3 vs. 12 ± 4 days; P = 0.04). The IMT group had a lower rate of atelectasis and pneumonia. Conclusion: IMT does not minimize the loss of functional capacity, but it reduces pulmonary complications and the length of stay of patients undergoing CABG who are preoperatively at a high risk of pulmonary complications. Relevance for Patients: The increase in ventilatory muscle strength, associated with IMT, can reduce PO pulmonary complications, resulting in shorter hospital stays, and improved quality of life.