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Introduction: Acute stroke interventions, such as stroke units and reperfusion therapy, have the potential to improve outcomes. However, there are many disparities in patient characteristics and access to the best stroke care. Thus, we aim to compare patient-reported outcome measures (PROMs) after stroke in two stroke centers representing the public and private healthcare systems in Brazil. Methods: PROMs through the International Consortium for Health Outcomes Measures (ICHOM) were assessed at 90 days after the stroke to compare two Brazilian hospitals in southern Brazil: a public university and a private stroke center, both with stroke protocols and stroke units. Results: When compared with the private setting (n = 165), patients from the public hospital (n = 175) were younger, had poorer control of risk factors, had more frequent previous strokes, and arrived with more severe strokes. Both hospitals had a similar percentage of IV thrombolysis treatment. Only 5 patients received mechanical thrombectomy (MT), all in the private hospital. Public hospital patients presented significantly worse outcomes at 3 months, including worse quality of life and functional dependence (60 vs. 48%, p = 0.03). Poor outcome, as measured by the mRS score, was significantly associated with older age, higher NIHSS score, and the presence of heart failure. However, the public practice was a strong predictor of any self-reported disability. Conclusion: Patients assisted at a good quality public stroke center with the same protocol used in the private hospital presented worse disability as measured by mRS and patient-reported outcome measures, with greater inability to communicate, dress, toilet, feed, and walk.

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O objetivo deste estudo foi examinar os efeitos da distribuição da carga interna de treinamento no desempenho de salto vertical durante a pré-temporada em jogadores de voleibol. A amostra foi composta por 11 jogadores de voleibol da Superliga Masculina de Voleibol (26,4±5,7 anos; 96,6±9,0 kg; 197,6±7,8 cm; 8,1±2,8% de gordura). A pré-temporada foi composta por 11 semanas de treinamento, dividida em três etapas: Etapa 1, com duração de 6 semanas; Etapa 2, com duração de 3 semanas; Etapa 3, com duração de 2 semanas. A carga interna de treinamento foi avaliada em todas sessões de treinamento através da percepção subjetiva de esforço da sessão, as percepções subjetivas de fadiga foram avaliadas ao final de cada semana, por meio da escala de bem-estar e o salto vertical com contra movimento foi avaliado ao final de cada etapa. Os resultados mostraram maiores valores de carga interna de treinamento em Etapa 1 em comparação a Etapa 2 (p = 0,02) e Etapa 3 (p = 0,01), alterações no estado de bem-estar dos atletas durante as três etapas analisadas, considerando os indicadores fadiga (F = 13,1; p < 0,001), estresse (F = 23,8; p < 0,001), humor (F = 16,7; p < 0,001) e bem-estar total (F = 11,2; p < 0,001) e também alterações significativas no salto vertical com contra movimento nos diferentes momentos de avaliação (F = 7,2; p < 0,01). Conclui-se que a distribuição de carga interna de treinamento, juntamente com as capacidades físicas trabalhadas, contribui para que ocorresse melhoria do desempenho no salto vertical com contra movimento e também redução da percepção de fadiga ao final da pré-temporada. (AU)

The aim of this study was to examine the effects of internal training load distribution on vertical jump performance during preseason in volleyball players. The sample consisted of 11 volleyball players from a Men's Volleyball Superliga (26.4 ± 5.7 years, 96.6 ± 9.0 kg, 197.6 ± 7.8 cm, 8.1 ± 2.8% of fat). The pre-season consisted of 11 weeks of training, divided into three stages: Stage 1, lasting 6 weeks; Stage 2, lasting 3 weeks; Stage 3, lasting 2 weeks. The internal training load was evaluated in all training sessions through the session of rating perception of exertion, the subjective perceptions of fatigue were evaluated at the end of each week, through the well-being scale and the vertical jump with counter movement was evaluated at the end of each stage. The results showed higher internal training load values in Stage 1 compared to Stage 2 (p = 0.02) and Stage 3 (p = 0.01), changes in the athletes' state of well-being during the three stages analyzed, considering the fatigue indicators (F = 13.1; p < 0.001), stress (F = 23.8; p < 0.001), mood (F = 16.7; p < 0.001) and total well-being (F = 11.2; p < 0.001) and also significant changes in vertical jump with counter movement at different moments of assessment (F = 7.2; p < 0.01). It is concluded that the distribution of internal training load contributes to an improvement in performance in the vertical jump with counter movement and also a reduction in the perception of fatigue at the end of the pre-season. (AU)

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Peripheral nerve injury is an important cause of incapability and has limited available treatment. Autologous donor nerve implant is the golden standard treatment, however, may cause secondary deficits. Stem cells show positive results in preclinical settings, preserving tissue and function. We tested the efficacy of stem cells derived from human exfoliated deciduous teeth seeded in poly (lactide-co-glycolide) scaffolds in sciatic nerve transection model. Seventy-two adult male Wistar rats had 7-mm nerve gap bridge using scaffolds with (or without) stem cells. Animals were randomly divided into: sham-operated; sham-operated without scaffold; sham-operated + scaffold + stem cells; sciatic transection + no treatment; sciatic transection + acellular scaffolds; sciatic transection + scaffold + stem cells. Sciatic Functional Index and Ladder Rung Walking tests were performed before (-1), 14 and 28 days after surgery. Morphometric nerve measurement and muscle weights were assessed. Scaffolds with stem cells improved function in Sciatic Functional Index. Acellular scaffold was effective, promoting functional recovery and nerve regeneration following nerve injury. Scaffolds provide better nerve regeneration and functional recovery after sciatic transection. Despite cell therapy promoting faster recovery after sciatic transection in the Sciatic Index Score, stem cells did not improve functional and morphological recovery after nerve injury. This is the first study testing the potential use of scaffolds combined with stem cells in the early stages after injury. Scaffolds with stem cells could accelerate nerve recovery and favor adjuvant therapies, evidencing the need for further studies to increase the knowledge about stem cells' mechanisms.

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