RESUMEN
OBJECTIVE: Controversial results on remdesivir efficacy have been reported. We aimed to report our real-life experience with the use of remdesivir from its availability in Spain. METHODS: We performed a descriptive study of all patients admitted for ≥48 hours with confirmed COVID-19 who received remdesivir between the 1st of July and the 30th of September 2020. RESULTS: A total of 123 patients out of 242 admitted with COVID-19 at our hospital (50.8%) received remdesivir. Median age was 58 years, 61% were males and 56.9 % received at least one anti-inflammatory treatment. No adverse events requiring remdesivir discontinuation were reported. The need of intensive care unit admission, mechanical ventilation and 30-days mortality were 19.5%, 7.3% and 4.1%, respectively. CONCLUSIONS: In our real-life experience, the use of remdesivir in hospitalized patients with COVID-19 was associated with a low mortality rate and good safety profile.
Asunto(s)
Adenosina Monofosfato/análogos & derivados , Alanina/análogos & derivados , Antivirales/uso terapéutico , Tratamiento Farmacológico de COVID-19 , Pacientes Internos , Adenosina Monofosfato/uso terapéutico , Anciano , Alanina/uso terapéutico , Antiinflamatorios/uso terapéutico , Anticuerpos Monoclonales Humanizados/uso terapéutico , COVID-19/mortalidad , Estudios de Cohortes , Dexametasona/uso terapéutico , Femenino , Mortalidad Hospitalaria , Humanos , Unidades de Cuidados Intensivos/estadística & datos numéricos , Masculino , Persona de Mediana Edad , Respiración Artificial/estadística & datos numéricos , España/epidemiología , Resultado del TratamientoRESUMEN
Two cases of spinal tuberculosis in atypical regions are presented; in the lumbosacral hinge and cranio-cervical regions respectively; focusing on the radiological appearance using Computed Tomography (CT) and Magnetic Resonance. With regard to these atypical presentations, the clinical history, epidemiology and radiology of spinal tuberculosis are reviewed.
Se presentan dos casos de tuberculosis espinal en localizaciones atípicas; la charnela lumbo-sacra y cráneo-cervical respectivamente; centrándonos en su aspecto radiológico por tomografía computarizada (TC) y resonancia magnética. A propósito de estas atípicas presentaciones se revisa la clínica, epidemiología y radiología de la tuberculosis en la columna vertebral.
Asunto(s)
Humanos , Masculino , Adulto , Femenino , Anciano de 80 o más Años , Imagen por Resonancia Magnética , Tomografía Computarizada por Rayos X , Tuberculosis de la Columna Vertebral/diagnósticoRESUMEN
Ion channel gating kinetics can be described using Kramers' diffusion theory of reaction rates between several closed and open states, where transition rates between states depend exponentially on the membrane potential V. It has been suggested that transition rates have a more complex dependence on V at voltage extremes, but this has never been quantified. We measured the rate constant of the last closed to open transition in a voltage-gated ion channel and show that it does not depend exponentially on membrane potential at values of V greater than ≈150 mV. To explain this behavior, we estimate the effects of electrical polarization of the water contained in crevices within the channel protein, using an electrostatic model of the approximate three-dimensional geometry and the nonlinear effects of charges on the polarization of water.