RESUMEN
The immunological study of more than 300 patients with purulent infection of soft tissues and shigellosis was carried out. The character and manifestation of the immunocorrecting action of sodium nucleinate were found to depend on the antigens of the AB0 system, which proved to be different in various type of pathology.
Asunto(s)
Sistema del Grupo Sanguíneo ABO/inmunología , Autoantígenos/inmunología , Enfermedades del Tejido Conjuntivo/inmunología , Disentería Bacilar/inmunología , HumanosRESUMEN
On the basis of a considerable number of facts--the results of the immunological survey of 197 patients with purulent infections of soft tissues and 103 shigellosis patients--the character and manifestation of immunological disturbances were found to depend on the genetic markers of blood (antigens of the AB0 system) which proved to differ in different type of pathology in patients.
Asunto(s)
Sistema del Grupo Sanguíneo ABO , Absceso/inmunología , Disentería Bacilar/inmunología , Infecciones de los Tejidos Blandos/inmunología , Sistema del Grupo Sanguíneo ABO/genética , Formación de Anticuerpos , Marcadores Genéticos , Humanos , Inmunidad Celular , FenotipoRESUMEN
The possibility of using sodium nucleinate for the treatment of acute dysentery has been confirmed in experiments on guinea pigs with the use of the keratoconjunctival test as an experimental model. The capacity of sodium nucleinate to enhance the antibiotic sensitivity of shigellae isolated from infected eyes to kanamycin, tetracycline and chloramphenicol has been established. The effect produced by individual ribonucleotides contained in sodium nucleinate have been studied and found to be differently directed.
Asunto(s)
Adyuvantes Inmunológicos/uso terapéutico , Disentería Bacilar/tratamiento farmacológico , Queratoconjuntivitis/tratamiento farmacológico , Ácidos Nucleicos/uso terapéutico , Ribonucleótidos/uso terapéutico , Shigella flexneri , Animales , Modelos Animales de Enfermedad , Evaluación Preclínica de Medicamentos , Quimioterapia Combinada , Cobayas , Inducción de Remisión , Factores de TiempoRESUMEN
The relationship of blood groups and level of immunological reactivity was studied in 500 patients with different diseases and 246 healthy subjects. Distribution of genetic markers of blood groups in the healthy and patients showed certain characteristic features. It was found that the A (11) blood group in the healthy may be considered a marker of high levels of immunological reactivity resulting in a milder course of diseases in persons of this blood group. It was shown that different pathological states are characterized by variations of immunological reactivity depending on the blood group--on the content of populations and subpopulations of lymphocytes, immunoglobulin of different classes, normal antibodies, grade of immunodeficiency.