RESUMEN

Thin-layer chromatography on silica gel was used to identify individual gangliosides in the rat brain, cardiac, renal, spleen, pancreatic and skeletal muscles in health and to measure the content of sialic acid in the above organs. A dramatic decrease in mono-, di-, tri- and polysialoganglioside levels was seen in tissues of rats with alloxan diabetes. The data obtained indicate that insulin reception disorders may be provoked by the reduced content of acidic glycolipids in plasma membranes.

Asunto(s)

Diabetes Mellitus Experimental/metabolismo , Glucolípidos/metabolismo , Aloxano , Animales , Encéfalo/metabolismo , Riñón/metabolismo , Masculino , Músculos/metabolismo , Miocardio/metabolismo , Páncreas/metabolismo , Ratas , Ácidos Siálicos/metabolismo , Bazo/metabolismo