RESUMEN
Candida arthritis is infrequent in patients who are not intravenous drug users. We describe a patient who was not an intravenous drug user and without other predisposing factors who developed knee arthritis caused by Candida albicans. We believe that this is the first report of such a case.
Asunto(s)
Artritis Infecciosa/microbiología , Candida albicans/aislamiento & purificación , Candidiasis/complicaciones , Inmunocompetencia , Anciano , Antifúngicos/uso terapéutico , Artritis Infecciosa/complicaciones , Artritis Infecciosa/tratamiento farmacológico , Candida albicans/efectos de los fármacos , Candidiasis/tratamiento farmacológico , Fluconazol/uso terapéutico , Humanos , Articulación de la Rodilla/microbiología , MasculinoRESUMEN
We report a case of a 53-year-old woman diagnosed of systemic sclerosis. She underwent an episode of pulmonary haemorrhage, characterized by haemoptysis, sudden anaemization, and bilateral alveolar infiltration during her hospitalization, which was resolved with steroid treatment. Subsequently, she developed a focal necrotizing glomerulonephritis. After searching in the literature, we have found only three cases of systemic sclerosis associated with pulmonary haemorrhage. We discuss the etiopathogenesis of this association and stress the importance of early steroid therapy.
Asunto(s)
Glomeruloesclerosis Focal y Segmentaria/complicaciones , Hemorragia/complicaciones , Enfermedades Pulmonares/complicaciones , Esclerodermia Sistémica/complicaciones , Femenino , Glomeruloesclerosis Focal y Segmentaria/tratamiento farmacológico , Hemorragia/tratamiento farmacológico , Humanos , Enfermedades Pulmonares/tratamiento farmacológico , Persona de Mediana Edad , Esteroides/uso terapéuticoRESUMEN
Thirty-two toxic oil syndrome (TOS) patients were selected because they presented with scleroderma-like changes and were observed during the first 36 months of evolution of the disease. Initially, these patients presented with a noncardiogenic pulmonary edema, eosinophilia, arthralgia/arthritis, peripheral edema, and myositis. Histologic investigations showed a widespread chronic interstitial infiltrate with lymphocytic vasculitis. They subsequently developed peripheral neuropathy, joint contractures, scleroderma-like changes, Raynaud phenomenon, pulmonary hypertension, sicca syndrome, and liver disease. Biopsy studies during this stage showed fibrosis and obliterating arteriopathy. Late features of TOS are musculoskeletal pain, cramps, livedo reticularis, carpal tunnel syndrome, and digital tuft changes. TOS is a new chemically induced scleroderma-like syndrome with features overlapping those of eosinophilic fasciitis, systemic sclerosis, and forms of localized scleroderma.