RESUMEN

We report two cases with common variable immunodeficiency. Both of them had gammaglobulin concentration lower than 300 mg/dL and evolved differently. The first one had three pneumonic episodes that responded satisfactorily to antibiotics. Today, this patient presents only two or three sinusitis clinical schemes per year, and has a good response to treatment. The second one has a bad evolution and presents hematological problems like thrombocytopenia and neutropenia. She also suffers lymphoid nodular hyperplasia in the intestinal tract and atrophy in the intestinal. These cases illustrate the wide clinical, immunological and genetic variety of the syndrome.

Asunto(s)

Inmunodeficiencia Variable Común , Antibacterianos/uso terapéutico , Terapia Combinada , Inmunodeficiencia Variable Común/complicaciones , Inmunodeficiencia Variable Común/genética , Inmunodeficiencia Variable Común/inmunología , Diarrea/etiología , Susceptibilidad a Enfermedades , Femenino , Filgrastim , Heterogeneidad Genética , Factor Estimulante de Colonias de Granulocitos/uso terapéutico , Humanos , Masculino , Persona de Mediana Edad , Neutropenia/tratamiento farmacológico , Neutropenia/etiología , Neumonía/tratamiento farmacológico , Neumonía/etiología , Seudolinfoma/etiología , Púrpura Trombocitopénica Idiopática/complicaciones , Proteínas Recombinantes , Recurrencia , Sinusitis/tratamiento farmacológico , Sinusitis/etiología , Trombocitopenia/tratamiento farmacológico , Trombocitopenia/etiología , gammaglobulinas/uso terapéutico