RESUMEN

We describe three patients with chronic, active Epstein-Barr virus infection associated with Kawasaki disease-like coronary artery aneurysms. The Epstein-Barr virus genome was detected in three cardiac tissue samples and one aortic tissue sample examined by means of the polymerase chain reaction. These findings suggest that chronic Epstein-Barr virus infection may play a pathogenic role in the development of coronary artery aneurysms.

Asunto(s)

Aorta/química , Aneurisma Coronario/diagnóstico , ADN Viral/análisis , Herpesvirus Humano 4/genética , Mononucleosis Infecciosa/diagnóstico , Síndrome Mucocutáneo Linfonodular/diagnóstico , Miocardio/química , Anticuerpos Antivirales/sangre , Southern Blotting , Niño , Preescolar , Enfermedad Crónica , Aneurisma Coronario/etiología , Femenino , Herpesvirus Humano 4/inmunología , Humanos , Mononucleosis Infecciosa/complicaciones , Masculino , Síndrome Mucocutáneo Linfonodular/complicaciones , Reacción en Cadena de la Polimerasa