RESUMEN

Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-cell neoplasm. The health of ATL patients rapidly deteriorates resulting in death; however, the induction of death in a small animal model due to tumor has not yet been reported. SCID mice, 5 weeks old, younger than those previously used, which were inoculated with ATL cells, eliminated NK cell activity and showed rapid tumor formation resulting in death. Age is the crucial factor influencing tumor formation and death in the SCID mice model for cancer.

Asunto(s)

Infecciones por HTLV-I , Virus Linfotrópico T Tipo 1 Humano/genética , Huésped Inmunocomprometido , Leucemia de Células T , Ensayos Antitumor por Modelo de Xenoinjerto , Factores de Edad , Animales , beta-Globulinas/análisis , beta-Globulinas/genética , Transformación Celular Viral , ADN de Neoplasias/análisis , Productos del Gen tax/análisis , Productos del Gen tax/genética , Virus Linfotrópico T Tipo 1 Humano/inmunología , Células Asesinas Naturales/inmunología , Leucemia de Células T/inmunología , Leucemia de Células T/mortalidad , Leucemia de Células T/virología , Masculino , Ratones , Ratones SCID , Reacción en Cadena de la Polimerasa , Tasa de Supervivencia