RESUMEN
AIM: To evaluate the association of the DRD2 gene and DRD2 x HTR2C interaction with hedonic and activational aspects of approach motivation in schizophrenia. MATERIAL AND METHODS: Genotypes at polymorphic loci DRD2 rs1800497 and HTR2C rs6318 (Cys23Ser) were identified in a sample that included 174 patients with schizophrenic spectrum disorders and 268 healthy subjects without a family history of psychoses. The participants completed the BIS/BAS and Temporal Experience of Pleasure Scale (TEPS). RESULTS AND CONCLUSION: A MANCOVA with sex and age as covariates revealed the effect of the 'DRD2 x HTR2C x diagnosis' interaction on the BAS scores (p=0.033). The effect was significant for the Fun-Seeking and Drive scales. Among patients, the carriers of the DRD2 TT/CT x HTR2C GG/G genotype showed the highest scores on the both scales, and those with the minor alleles in the two loci had the lowest ones. Differences between these groups were nominally significant for both the Fun-Seeking and Drive, but did not survive the correction for multiple comparisons. Among controls, subjects without minor alleles demonstrated the highest scores on these two scales. They differed significantly from the carriers of the DRD2 TT/CT+HTR2C GG/G genotype on the Fun-Seeking (p=0.008). No effects of DRD2 and HTR2C on TEPS scores were found. In general, the results of the study can be interpreted in favor of the hypothesis about the role of the HTR2C and DRD2 genes interaction in the variability of the activational aspects of approach motivation in schizophrenia and healthy subjects. However, the lack of differences survived correction for multiple comparisons makes it difficult to interpret the revealed effects.
Asunto(s)
Motivación , Esquizofrenia , Alelos , Genotipo , Heterocigoto , Humanos , Polimorfismo de Nucleótido Simple , Proteínas Serina-Treonina Quinasas , Receptor de Serotonina 5-HT2CRESUMEN
The receptor specificity (RS) of pandemic influenza A(H1N1) pdm09 virus strains deposited into the State Collection of Viruses of the Russian Federation, D. I. Ivanovsky Research Institute of Virology, Ministry of Health and Social Development of Russia, in the 2009-2010 and 2010-2011 epidemic seasons to a panel of 9 sialoglycopolymers (SGP). The strains were divided into 3 groups according to the W(3/6) index proposed by the authors, which was equal to the amount of reactivities to unbranched alpha2-3-SGP to that of reactivities to unbranched alphal-6-SGP: W(3/6) < or = 1.0; 1.0 < W(3/6) < or = 1.5. The W(3/6) < or = 1.5 group showed a predominance of a2-3-RS, attended by the high incidence of fatal primary viral pneumonias (FPVP) (60.0%) and amino acid replacements in the HA1 receptor-binding site (RBS) (80.0%): D222{G, N} and Q223R. The 1.0 < W(3/6) < or = 1.5 group was characterized by mixed alpha2-3/alpha2-6-RS with the incidence of FPVP (29.7%) and amino acid replacements in the HA1 RBS (40.5%) (D222{G, N, V} and Q223), respectively. In the W(3/6) < or = 1.0 group, alpha2-6-RS was prevalent, FPVPs were absent and amino acid replacements in HA1 RBS (D222{G, E}) were seen only in 6.0% of cases. The number of strains with increased specificity to alpha2-3-sialosides increased in the 2010-2011 epidemic season as compared to the previous season. With their further spread among the population, there may be a rise in cases of severe primary viral pneumonias with possible fatal outcomes, which can be, however, accompanied by a decrease in the capacity of mutants to air-dropwise transmission.
Asunto(s)
Hemaglutininas/genética , Subtipo H1N1 del Virus de la Influenza A/metabolismo , Gripe Humana/mortalidad , Neumonía Viral/mortalidad , Receptores Virales/química , Proteínas Virales/genética , Sustitución de Aminoácidos , Sitios de Unión , Hemaglutininas/metabolismo , Humanos , Subtipo H1N1 del Virus de la Influenza A/genética , Subtipo H1N1 del Virus de la Influenza A/patogenicidad , Gripe Humana/complicaciones , Gripe Humana/transmisión , Gripe Humana/virología , Imitación Molecular , Pandemias , Neumonía Viral/etiología , Neumonía Viral/transmisión , Neumonía Viral/virología , Polímeros/química , Polímeros/metabolismo , Probabilidad , Receptores Virales/genética , Receptores Virales/metabolismo , Federación de Rusia/epidemiología , Sialoglicoproteínas/química , Sialoglicoproteínas/metabolismo , Análisis de Supervivencia , Proteínas Virales/metabolismoRESUMEN
The course of anesthesia during uterine extirpation for large and giant myomas depends on the efficiency of blood loss compensation and relative hypovolemia after rapid decompensation when a mass is removed. Thirty-five patients with a uterine myoma with the size corresponding to 18-40-week gestation were examined. Dextrans and voluven (hydroxyethylstarch 130/0.4) were used in Groups 1 (n = 20) and 2 (n = 15). The intraoperative administration of voluven reduced the volume of crystalloids and a need for sympathomimetics and maintained the normal amount of fluid and sectoral distribution.
Asunto(s)
Anestesia , Derivados de Hidroxietil Almidón/uso terapéutico , Hipovolemia/tratamiento farmacológico , Complicaciones Intraoperatorias/tratamiento farmacológico , Leiomioma/cirugía , Neoplasias Uterinas/cirugía , Útero/cirugía , Pérdida de Sangre Quirúrgica , Soluciones Cristaloides , Dextranos/uso terapéutico , Femenino , Humanos , Soluciones Isotónicas/uso terapéutico , Persona de Mediana Edad , Almidón/uso terapéuticoRESUMEN
AIM: To develop a quantitative method of evaluation of the volume and degree of intraoperative blood loss. MATERIAL AND METHODS: Blood loss quantitation is based on maximal collection of the lost blood and its measurement by lost globular volume (GV), i.e. erythrocyte containing medium with Ht 1.0. RESULTS: The total of the components of lost GV was termed estimated blood loss (EBL). Its amount was calculated by GV deficiency from the due in the patient and volume of lost blood. The method was tried in surgical and traumatological practice in 317 operated patients (multitrauma--65, hip bone fractures -98, uterine myoma -105, aneurysm of abdominal aortic part -49). CONCLUSION: The volume of blood loss guided the physician to reestablish volume of circulating blood--the volume of infused blood exceeded EBL 1.3-1.7-fold. GV deficiency (in %) showed severity of blood loss and gave approaches to its adequate compensation.