RESUMEN
AIM: To analyze the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in tumors of patients with renal cell carcinoma to determine whether they could be used as diagnostic markers. MATERIALS AND METHODS: The relative expression of hsa-miR-30c-5p and hsa-miR-138-1 was compared in the paired samples of kidney tumor tissue and conventionally normal tissue adjacent to the tumor. RESULTS: We found a significant decrease in miR-30c-5p and miR-138-1 levels in tumor tissues even in the cases of early stage cancer. In addition, miR-138-1 expression was lower in renal cell carcinoma Fuhrman grade G3 + G4 as compared to Fuhrman grade G2. However, we found no association between miR-30c-5p and miR-138-1 expression in the tumors and the major clinical and pathological characteristics of renal cell carcinoma patients. CONCLUSIONS: A significant reduction in the expression levels of hsa-miR-30c-5p and hsa-miR-138-1 in renal cell carcinoma indicates the feasibility of further studies on the probable diagnostic utility of these markers.
Asunto(s)
Carcinoma de Células Renales/genética , Regulación Neoplásica de la Expresión Génica , Neoplasias Renales/genética , MicroARNs/genética , Adulto , Anciano , Biomarcadores de Tumor/genética , Carcinoma de Células Renales/mortalidad , Carcinoma de Células Renales/patología , Femenino , Humanos , Neoplasias Renales/mortalidad , Neoplasias Renales/patología , Masculino , Persona de Mediana Edad , Tasa de SupervivenciaRESUMEN
Data are submitted on the pattern of reasons for hospitalization, rehospitalization of patients with glomerulonephritis depending on the purpose and duration of the in-patient care over three-year activity of the regional nephrologic department. The authors have come to the conclusion that it is necessary that an expert evaluation of quality of diagnosis and treatment of glomerulonephrities patients should be carried out, which measure will, we believe, help in uncovering the existing shortcomings and their causes during stages of medical care delivery and in finding ways for improvement of the system of the nephrological service with special reference to such kinds of it as day clinics and domociliary medical services.
Asunto(s)
Glomerulonefritis/terapia , Hospitalización , Glomerulonefritis/diagnóstico , Departamentos de Hospitales/estadística & datos numéricos , Hospitales de Distrito , Humanos , Tiempo de Internación , Evaluación de Procesos y Resultados en Atención de Salud , Admisión del Paciente , Readmisión del Paciente , Evaluación de Programas y Proyectos de Salud , Estudios Retrospectivos , UcraniaRESUMEN
Based on expert examination of 296 histories of 145 patients with glomerulonephritis the frequency of errors being made in examining of patients at the prehospital stage, in hospital, has been estimated. Kinds of errors include diagnostic errors (primarily in defining forms and variants of the disease), errors in administering treatments to patients. This necessitated raising the level of the primary link in the nephrological educational program for medical men and warrants development of alternative forms of the in-patient medical care delivery to patients with glomerulonephritis.