Asunto(s)
Sustitutos de Huesos/química , Técnicas de Cultivo/métodos , Durapatita/química , Materiales Manufacturados , Ensayo de Materiales , Compuestos Organofosforados/química , Polímeros/química , Ingeniería de Tejidos/métodos , Células 3T3/fisiología , Células 3T3/ultraestructura , Implantes Absorbibles , Animales , Materiales Biocompatibles/efectos adversos , Materiales Biocompatibles/síntesis química , Materiales Biocompatibles/química , Sustitutos de Huesos/efectos adversos , Sustitutos de Huesos/síntesis química , Adhesión Celular/fisiología , División Celular/fisiología , Células Cultivadas , Durapatita/síntesis química , Elasticidad , Matriz Extracelular/fisiología , Matriz Extracelular/ultraestructura , Ratones , Compuestos Organofosforados/síntesis química , Polímeros/síntesis química , Propiedades de SuperficieRESUMEN
Traditional materials for bone repair or replacements such as autografts and allografts have a limited supply and other complications. Thus, alternative materials need to be explored. Three-dimensional, porous composites prepared from bioresorbable polymers and hydroxyapatite or other calcium phosphate ceramics are promising materials for the repair or replacement of diseased or damaged bone. However, in many cases the ceramic component of these composites is crystalline in nature, while bone apatite is made of a poorly crystalline, carbonated phosphate system. In this study, we synthesized a noncrystalline, carbonated calcium phosphate ceramic by carrying out the reaction within bioresorbable PLAGA microspheres using a modified emulsion/solvent evaporation technique, making each individual microsphere a composite. Sintering the composite microspheres together yielded a bioresorbable, porous, 3-dimensional scaffold that may be ideal for tissue ingrowth, making this composite scaffold potentially suitable for bone repair applications.
Asunto(s)
Sustitutos de Huesos/síntesis química , Fosfatos de Calcio/síntesis química , Cerámica/síntesis química , Sustitutos de Huesos/química , Fosfatos de Calcio/química , Cerámica/química , Humanos , Técnicas In Vitro , Ensayo de Materiales , Microscopía Electrónica de Rastreo , Microesferas , Tamaño de la Partícula , Difracción de Rayos XRESUMEN
The authors present six cases of olfactory neuroblastoma with or without intracranial extension operated on by the team headed by Otolaryngologists and Neurosurgeons. Data was analysed with respect lo age group, sex, presenting symptoms and signs, stage, and results of combined modality of treatment. The author's experience suggests excellent local control can be achieved by combined craniofacial resection followed by radiation therapy. Hence the authors recommend planned combined radical treatment for all the resectable lesions and routine use of nasal endoscope along with other conventional methods for compehensive follow-up of all cases.
RESUMEN
Ionizing radiation used for the treatment of head and neck tumors affected epithelial and connective tissue. Epithelial lining of the middle ear mucosa desquamated, when exposed to conventional dose of radiation. Mucosa becomes oedematous which subsequently lead to formation and collection of sterile fluid within middle ear cavity and thus producing radiation otitis media with conductive deafness. Radiation induced changes in the structure surrounding the end organs of hearing such as vascular and connective tissue alterations which later eventually could affect the end organ leading to perceptive type of hearing loss as a result of chronic anoxia to end organ.
Asunto(s)
Neoplasias de Cabeza y Cuello/radioterapia , Trastornos de la Audición/etiología , Radioterapia/efectos adversos , Humanos , Persona de Mediana EdadRESUMEN
Neurofibroma of the tongue arising from the hypoglossal nerve is rare [7], but a combined neurofibroma of the hypoglossal and lingual nerve is extremely rare in the English literature to our knowledge [4,6]. Here one such case is being presented for its rarity, peculiarity of its clinical presentation and the surgical approach to excise it.
Asunto(s)
Nervio Hipogloso/patología , Nervio Lingual/patología , Neurofibroma/diagnóstico , Neoplasias de la Lengua/diagnóstico , Adolescente , Humanos , Masculino , Neurofibroma/cirugía , Neurofibromatosis 1/diagnóstico , Neoplasias de la Lengua/cirugíaRESUMEN
Osteogenic sarcoma involving the sphenoid bone is an extremely rare condition. The rarity of the disease and the close proximity of the sphenoid bone to the various important intracranial structures poses a real challenge in diagnosis and surgical management of these lesions. An extended lateral craniofacial resection by a multidisciplinary approach was carried out in one such case to attempt en bloc resection. This case is presented and also a review of the relevant literature.
Asunto(s)
Osteosarcoma/cirugía , Neoplasias Craneales/cirugía , Hueso Esfenoides , Adulto , Exoftalmia/etiología , Femenino , Humanos , Osteosarcoma/complicaciones , Neoplasias Craneales/complicaciones , Tomografía Computarizada por Rayos XRESUMEN
An air gun pellet lodged in the posterior ethmoid sinus in a 1-year-old child is described. Functional endoscopic sinus surgery enabled the removal of the pellet, obviating an external ethmoidectomy.
Asunto(s)
Senos Etmoidales/cirugía , Cuerpos Extraños/cirugía , Endoscopía , Humanos , Lactante , Masculino , Heridas por Arma de FuegoRESUMEN
Congenital carotid aneurysms are frequently found in the intracranial arteries but rarely seen in extracranial part of the internal carotid artery. A case of a congenital internal carotid artery aneurysm at the skull base was treated in a 13-year-old female child. This case is being presented for its rarity and also to highlight the ease of exposing the upper end of the aneurysm via lateral skull base approach. Infratemporal fossa approach was adopted in this case. The carotid canal was drilled off and the upper end of the aneurysm in the intrapetrous part was mobilized and vascular clip applied before dissection of the aneurysm. Relevant literatures pertaining to this case are also reviewed.