RESUMEN

We have synthesised a number of analogues of lipid X, a precursor in the biosynthesis of LPS, some of which exhibit marked antagonism of LPS induced TNF production in vivo. These compounds provide new non-polar leads in the search for a therapy for endotoxic shock.

Asunto(s)

Ácidos Carbocíclicos/síntesis química , Glucolípidos/biosíntesis , Lipopolisacáridos/antagonistas & inhibidores , Factor de Necrosis Tumoral alfa/biosíntesis , Ácidos Carbocíclicos/farmacología , Interacciones Farmacológicas , Humanos , Técnicas In Vitro , Lipopolisacáridos/farmacología , Choque Séptico/tratamiento farmacológico