RESUMEN

Varicocele is among the most common problems which may lead to male infertility. Spermatogenesis is impaired as a consequence of this vascular defect, through mechanisms that are not well described. This study aimed to evaluate serum hormonal level (inhibin B, FSH and testosterone) and seminal plasma antioxidant defence levels after folic acid and zinc sulphate administration in varicocelectomised patients. Participants were randomly allocated to four experimental groups. Our randomisation schedule was as follows: zinc sulphate/folic acid, folic acid, zinc sulphate and placebo. The patients underwent varicocelectomy, before which a blood and semen sample were obtained and also three and six months after varicocelectomy for evaluation of blood hormonal level (FSH, testosterone, inhibin B) and seminal oxidative stress status (nitric oxide, superoxide dismutase, total antioxidant capacity). Patients in different groups took orally one capsule per day after dinner following varicocelectomy for 6 months. A significant rise in peripheral blood inhibin B and seminal plasma activity was detected in the zinc sulphate/folic acid group after 6 months. The present clinical trial indicates a change in the hormonal status of varicocelectomised patients following long-term administration of zinc sulphate and folic acid.

Asunto(s)

Ácido Fólico/uso terapéutico , Varicocele/tratamiento farmacológico , Varicocele/metabolismo , Sulfato de Zinc/uso terapéutico , Antioxidantes/metabolismo , Quimioterapia Combinada , Ácido Fólico/administración & dosificación , Hormona Folículo Estimulante/sangre , Humanos , Infertilidad Masculina/tratamiento farmacológico , Infertilidad Masculina/etiología , Infertilidad Masculina/metabolismo , Inhibinas/sangre , Masculino , Óxido Nítrico/metabolismo , Semen/efectos de los fármacos , Semen/metabolismo , Superóxido Dismutasa/metabolismo , Testosterona/sangre , Varicocele/complicaciones , Sulfato de Zinc/administración & dosificación

RESUMEN

The complexation reactions between Ni(2+), Co(2+) and Zn(2+) metal ions with PAN in methanol (MeOH), acetonitrile (AN) and dimethyl sulfoxide (DMSO) were studied using a spectrophotometric method. The stability constants of the resulting complexes were determined from computer fitting absorbance mole-ratio data. The results revealed that the stability constants of complexes are varying in order of Ni(2+)

Asunto(s)

Metales/química , Naftoles/química , Solventes/química , Espectrofotometría/métodos , Acetonitrilos/química , Dimetilsulfóxido/química , Iones , Cinética , Ligandos , Metanol/química , Soluciones , Termodinámica