Asunto(s)
Radiofármacos , Ácido Dimercaptosuccínico de Tecnecio Tc 99m , Procedimientos Innecesarios , Infecciones Urinarias/diagnóstico por imagen , Adolescente , Niño , Preescolar , Femenino , Humanos , Lactante , Recién Nacido , Enfermedades Renales/diagnóstico por imagen , Masculino , CintigrafíaAsunto(s)
Anemia/inducido químicamente , Inhibidores de la Enzima Convertidora de Angiotensina/efectos adversos , Enalapril/efectos adversos , Síndrome Nefrótico/tratamiento farmacológico , Inhibidores de la Enzima Convertidora de Angiotensina/uso terapéutico , Niño , Enalapril/uso terapéutico , Eritropoyetina/metabolismo , Femenino , Humanos , Síndrome Nefrótico/fisiopatologíaRESUMEN
The relationship between physical activity, glycaemic control, and skinfold thickness was studied in children with diabetes. Patients recorded details of activity in a home diary over a 6-day period, and provided eight serial capillary dried blood spots for glucose analysis during a 24-h period. Levels of activity were assessed using a semi-quantitative scoring scheme. No correlation was found between total activity score and glycaemic control. However, the activity score before 9 am showed significant correlation with mean blood glucose (p = 0.005) and fructosamine (p = 0.04). The time of rising in the morning showed significant correlation with blood glucose after lunch (p = 0.004) and with fructosamine (p = 0.04). A significant correlation was found between early morning activity and subscapular skinfold thickness. The association between activity and glycaemic control warrants further investigation, as it suggests that patients who engage in energetic activity early in the morning may achieve lower blood glucose and fructosamine levels than their less active peers.
Asunto(s)
Glucemia/metabolismo , Diabetes Mellitus Tipo 1/fisiopatología , Ejercicio Físico , Esfuerzo Físico , Adolescente , Biomarcadores/sangre , Niño , Preescolar , Diabetes Mellitus Tipo 1/sangre , Femenino , Fructosamina/sangre , Humanos , Masculino , Análisis de Regresión , Descanso , Sueño , DeportesRESUMEN
The relationship between the insulin-breakfast interval, postprandial increase in blood glucose, and glycaemic control was studied in 58 children with diabetes. Patients recorded insulin-breakfast intervals in a home diary over a seven day period, and during a 24 hour period at the weekend provided eight serial capillary dried blood spots for glucose analysis. The highest mean blood glucose value occurred two hours after breakfast and showed a significant correlation with fructosamine concentrations. Weekend insulin-breakfast intervals ranged from 2-30 minutes, with 70% reporting intervals of less than 15 minutes. There was a significant correlation between the weekend insulin-breakfast interval and the after breakfast increase in blood glucose with a mean increment of 0.4 mmol/l in the 30 minute group and 7.2 mmol/l in the 2 minute group. Over the whole study period, children with mean insulin-breakfast intervals of two to 12 minutes had a mean fructosamine concentration of 376 mumol/l compared with 341 mumol/l in those with intervals of 15-35 minutes. This study has shown that the interval between insulin injection and breakfast significantly influences the morning postprandial rise in blood glucose and consequently short term glycaemic control. It is therefore important that patients are encouraged to leave an interval of about 30 minutes between insulin injection and breakfast.