RESUMEN
The antimicrobial properties of the drug Cheblin-CK-1 (CCK-1) were determined in mice intraabdominally inoculated with Proteus mirabilis-4691 in a dose of 140-200 million daily cultured microbial bodies. Its comparison agent was ampicillin. CCK-1 was found to act as an antibiotic similar to ampicillin in its effects. The antimicrobial activity of CCK-1 against Staphylococcus aureus and Escherichia coli isolated from the contents of echinococcal cysts from patients operated on was also established. Its echinococcidial activity was found in experiments on the cotton rats and piglets inocculated with echinococci. CCK-1 was also tested on volunteers. Before surgery, 186 patients with echinococcosis took the drug and 26 patients with the same disease did not and they served as controls. At first the drug suppressed the growth of parasitic larvocysts with destruction and death of 85-95% of germinal elements of larvocysts and then killed parasites. In patients receiving a complete course of its therapy, protein and amino acid metabolisms restored, followed by immunity recovery.
Asunto(s)
Antihelmínticos/uso terapéutico , Antibacterianos/uso terapéutico , Equinococosis/tratamiento farmacológico , Echinococcus/efectos de los fármacos , Factores Inmunológicos/uso terapéutico , Nueces , Fitoterapia , Animales , Bovinos , Modelos Animales de Enfermedad , Equinococosis/inmunología , Experimentación Humana , Humanos , Larva/efectos de los fármacos , Larva/crecimiento & desarrollo , Masculino , Ratones , Extractos Vegetales/uso terapéutico , Infecciones por Proteus/tratamiento farmacológico , Proteus mirabilis , Ratas , Sigmodontinae , PorcinosRESUMEN
In autobred albino mice, the maximum nonlethal dose of the agent CK-1 was established, which was 19.0 g/kg, the agent was nontoxic. Cotton rats aged 30-45 days were infected by alveococcosis from a donor rat. The methods and formulas developed by Mikhailitsin et al. were used during experiments and investigations. At the beginning of treatment, 5 rats were found to have a great deal of parasitic larvocysts (PL) 10 days after infection. Eight rats formed a control group, 8 were treated with CK-1 in a constantly increasing doses of 0.1, 0.26, and 0.34 g/kg for 3 weeks. Following 40 days of infection, the animals were anesthesized and CK-1 was ascertained to have a high antialveococcal activity: the index of suppressed PL growth was 90.23 to 92.74%. In 14 piglets aged 1 month, infected by echinococcosis strains and treated CK-1 in high doses, was established to cause echinococcal death. In 14 puppies, the agent was highly effective in strobular echinococcosis.
Asunto(s)
Anticestodos/uso terapéutico , Modelos Animales de Enfermedad , Equinococosis/tratamiento farmacológico , Animales , Anticestodos/toxicidad , Perros , Relación Dosis-Respuesta a Droga , Evaluación Preclínica de Medicamentos , Equinococosis/parasitología , Femenino , Masculino , Ratones , Sigmodontinae , Porcinos , Factores de TiempoAsunto(s)
Adyuvantes Inmunológicos/uso terapéutico , Colecistitis/complicaciones , Síndromes de Inmunodeficiencia/tratamiento farmacológico , Sulfonas/uso terapéutico , Uracilo/análogos & derivados , Enfermedad Aguda , Anciano , Combinación de Medicamentos/uso terapéutico , Humanos , Persona de Mediana Edad , Uracilo/uso terapéuticoAsunto(s)
Enfermedades de las Vías Biliares/diagnóstico , Laparoscopía/métodos , Hepatopatías/diagnóstico , Enfermedades Pancreáticas/diagnóstico , Colecistitis/diagnóstico , Colestasis/diagnóstico , Diagnóstico Diferencial , Neoplasias de la Vesícula Biliar/terapia , Humanos , Ictericia/diagnóstico , Laparoscopía/efectos adversosRESUMEN
Radioisotope angiography demonstrates successfully occlusion of the abdominal aorta, aneurysms of the thoracic and abdominal aorta, and occlusion of the iliac and femoral arteries. In occlusion of the renal artery this method supplements contrast vasography of the kidneys providing a quantitative concept of the functional peculiarities and dynamics of the renal blood flow. The results of radioisotope angiography were in full agreement with the clinical picture of the disease and the findings of contrast X-ray angiography in 81.7% of cases; in 11.3% they coincided partly and only in 7% of cases the results were dissimilar.