RESUMEN
Tissue from 50 cases of products of conception and placenta at different gestational ages from as early as 12 d post ovulation up to 40 wk were examined by immunoperoxidase technique for localization of HCG, HPL, SP1, and PAPP-A. HCG was localized in the cytoplasm of syncytiotrophoblast (ST) with strong intensity in the 12-d blastocyst and remained strong until 8 to 10 wk. It then gradually decreased, becoming almost negative in term placenta. HCG was also seen in the cytoplasm of intermediate trophoblast (IT) at the implantation site but with variability in staining. HPL and SP1 appeared later than HCG in ST, and the intensity of staining increased rapidly to strongly positive by wk 8. They remained strong until full term. IT stained strongly positive with HPL throughout pregnancy, and some were different from the HCG positive ones. ST were constantly negative for PAPP-A throughout pregnancy. The latter, however, was definitely seen in the cytoplasm of cytotrophoblast (CT) of early blastocyst, the superficial epithelium of the endometrium adjacent to the implantation site, in many decidual cells around the implantation site and in the amniotic membrane epithelium.
Asunto(s)
Amnios/metabolismo , Endometrio/metabolismo , Proteínas Gestacionales/metabolismo , Embarazo/metabolismo , Trofoblastos/metabolismo , Amnios/citología , Gonadotropina Coriónica/metabolismo , Gonadotropina Coriónica Humana de Subunidad beta , Endometrio/citología , Epitelio/metabolismo , Femenino , Humanos , Técnicas para Inmunoenzimas , Inmunohistoquímica/normas , Fragmentos de Péptidos/metabolismo , Lactógeno Placentario/metabolismo , Proteína Plasmática A Asociada al Embarazo/metabolismo , Glicoproteínas beta 1 Específicas del Embarazo/metabolismo , Trofoblastos/citologíaRESUMEN
Two patients with leiomyosarcomas are described, both men with lesions located in the upper trunk. Both lesions were present for more than 10 years. The diagnosis was established after excisional biopsy. The diagnostic criteria are a tumor size greater than 2.5 cm in diameter; a mitotic rate of 1 or more per 5 high-power fields in cellular areas; and electron microscopic verification of smooth muscle cells. The literature is reviewed and the clinical presentation of the 2 patients is discussed. Wide excision is the treatment of choice after histological diagnosis.
Asunto(s)
Leiomiosarcoma/cirugía , Neoplasias Cutáneas/cirugía , Humanos , Leiomiosarcoma/patología , Masculino , Persona de Mediana Edad , Piel/patología , Neoplasias Cutáneas/patologíaRESUMEN
A case of congenital glioblastoma multiforme in a premature hydropic female infant was studied. Study and results of a literature review show that teratoma is the commonest tumor in that age group, and that the sex distribution in newborns showed a slight preponderance in females, in contrast with the preponderance of these neoplasms in males among children and adults.
Asunto(s)
Neoplasias Encefálicas/congénito , Glioblastoma/congénito , Insuficiencia Cardíaca/complicaciones , Adulto , Encéfalo/patología , Neoplasias Encefálicas/complicaciones , Neoplasias Encefálicas/patología , Femenino , Glioblastoma/complicaciones , Glioblastoma/patología , Insuficiencia Cardíaca/mortalidad , Humanos , Recién Nacido , Recien Nacido Prematuro , Placenta/patología , Embarazo , Factores Sexuales , Cráneo/patologíaRESUMEN
The cerebral pathology in a case of tricyclic antidepressant overdose by amitriptyline is described. A review of the literature of similar cases is summarized. The relation of the cerebral lesions to the development of a hypertensive episode possibly induced by amitriptyline is discussed.