RESUMEN
The immunity system condition was studied in 118 patients with breast cancer of stage III who received combination chemotherapy: 91 patients--according to the Cooper scheme and 27 patients--according to CMF scheme. The reaction of lymphocyte blast transformation (LBT) was determined by three mitogens: phytohemagglutinin (PHA "O"), PHA "D" and lipopolysaccharide (LPS). The levels of Ig A, G, M were also determined. A decrease in immunological indices of different degree was observed in all patients. LBT was proved to have a high response to phytohemagglutinin "O" and it is recommended for immunological investigations. No significant changes in the immunological state of LPS were revealed.
Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Neoplasias de la Mama/tratamiento farmacológico , Activación de Linfocitos , Mitógenos/farmacología , Adulto , Anciano , Formación de Anticuerpos , Neoplasias de la Mama/inmunología , Femenino , Humanos , Lipopolisacáridos/farmacología , Persona de Mediana Edad , Fitohemaglutininas/farmacologíaRESUMEN
Immunologic response was studied in 91 cases of stage III breast cancer who received a CFMVP polychemotherapy. 23 patients were given decaris for immunostimulation. All cases showed a significant decrease in cellular immunity. CFMVP-treated patients showing a decrease of 30% and more should receive 300 mg of decaris twice a week for 3 weeks.