RESUMEN

The anti-inflammatory activity of Ficus racemosa extract was evaluated on carrageenin, serotonin, histamine and dextran-induced rat hind paw oedema models. The extract at doses of 200 and 400 mg/kg has been found to possess significant anti-inflammatory activity on the tested experimental models. The extract (400 mg/kg) exhibited maximum anti-inflammatory effect, that is 30.4, 32.2, 33.9 and 32.0% at the end of 3 h with carrageenin, serotonin, histamine, dextran-induced rat paw oedema, respectively. In a chronic test the extract (400 mg/kg) showed 41.5% reduction in granuloma weight. The effect produced by the extract was comparable to that of phenylbutazone, a prototype of a non-steroidal anti-inflammatory agent.

Asunto(s)

Antiinflamatorios no Esteroideos/farmacología , Plantas Medicinales/química , Animales , Carragenina , Dextranos , Edema/inducido químicamente , Edema/patología , Edema/prevención & control , Pie/patología , Granuloma/patología , Histamina , India , Masculino , Fenilbutazona/farmacología , Extractos Vegetales/farmacología , Hojas de la Planta/química , Ratas , Ratas Wistar , Serotonina