RESUMEN
A prevalência de dor crónica na população portuguesa é de 37%, provocando limitações físicas, psicológicas, sociais e uma clara diminuição da qualidade de vida. Em alguns tipos de dor crónica, os analgésicos opioides mostraram-se como as únicas alternativas passíveis de proporcionar controlo de dor, devendo a terapêutica recorrendo a este grupo ser iniciada quando todas as outras opções falharam. Este artigo pretende rever as principais características dos analgésicos opioides, incluindo efeitos secundários e formas farmacêuticas disponíveis, tanto para terapêutica basal como de resgate
Chronic pain has a prevalence of 37% in the Portuguese population, causing physical limitations, psychological and social problems and a great decrease in the quality of life. In many types of chronic pain, opioid drugs are the only options that can provide pain relief, and therapy using this pharmacotherapeutic group should be started when other options have failed. This paper aims to review the main characteristics of opioid analgesics, including side effects and available pharmaceutical forms, both for baseline and rescue therapy
Asunto(s)
Humanos , Dolor Crónico/tratamiento farmacológico , Analgésicos Opioides/uso terapéutico , Calidad de Vida , PortugalRESUMEN
Pannexins form single membrane channels that regulate the passage of ions, small molecules and metabolites between the intra- and extracellular compartments. In the central nervous system, these channels are integrated into numerous signaling cascades that shape brain physiology and pathology. Post-translational modification of pannexins is complex, with phosphorylation emerging as a prominent form of functional regulation. While much is still not known regarding the specific kinases and modified amino acids, recent reports support a role for Src family tyrosine kinases (SFK) in regulating pannexin channel activity. This review outlines the current evidence supporting SFK-dependent pannexin phosphorylation in the CNS and examines the importance of these modifications in the healthy and diseased brain.