RESUMEN
A para-articular osteochondroma is a rare osteocartilaginous tumour that arises in the soft tissue adjacent to a joint but with no attachment to the bone. To our knowledge, this is the first case of one reported in the region of the temporomandibular joint (TMJ). The patient presented with severe preauricular pain caused by a para-auricular osteochondroma, which arose in the preauricular region just external to the TMJ.
Asunto(s)
Osteocondroma/diagnóstico , Neoplasias de los Tejidos Blandos/diagnóstico , Articulación Temporomandibular/patología , Femenino , Humanos , Imagen por Resonancia Magnética , Cóndilo Mandibular/patología , Persona de Mediana Edad , Radiografía Panorámica , Tomografía Computarizada por Rayos XRESUMEN
A 73-year-old man presented with a painful swelling of the left temporomandibular joint with no other symptoms. Panoramic radiography showed an osteolytic lesion in the left mandibular body, while magnetic resonance imaging provided the most accurate view of an osteolytic lesion in the left condyle. Skeletal scintigraphy showed increased uptake in the mandibular anatomical area. A diagnosis of metastatic breast adenocarcinoma was made from mandibular biopsies which proved to be ductal carcinoma, with no evidence of any other metastases. Clinicopathologic features of this case are reviewed.
Asunto(s)
Neoplasias de la Mama Masculina/patología , Carcinoma Ductal de Mama/secundario , Neoplasias Mandibulares/secundario , Anciano , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Neoplasias de la Mama Masculina/diagnóstico por imagen , Neoplasias de la Mama Masculina/tratamiento farmacológico , Carcinoma Ductal de Mama/diagnóstico por imagen , Carcinoma Ductal de Mama/tratamiento farmacológico , Carcinoma Ductal de Mama/patología , Ciclofosfamida/uso terapéutico , Epirrubicina/uso terapéutico , Fluorouracilo/uso terapéutico , Humanos , Imagen por Resonancia Magnética , Masculino , Cóndilo Mandibular/patología , Neoplasias Mandibulares/diagnóstico por imagen , Neoplasias Mandibulares/tratamiento farmacológico , RadiografíaRESUMEN
Giant cell angiofibroma was first described as a distinctive orbital soft-tissue tumour in male adults; it is now recognized that this mesenchymal tumour can present in other anatomical regions. In this article, a case of giant cell angiofibroma of parapharyngeal space in a 25-year-old woman is described. Clinicopathologic features of this tumour are reviewed. To the authors' knowledge, this is the first reported case of giant cell angiofibroma arising in the parapharyngeal space.
Asunto(s)
Angiofibroma/diagnóstico , Neoplasias de la Parótida/diagnóstico , Neoplasias Faríngeas/diagnóstico , Antígeno 12E7 , Adulto , Antígenos CD/análisis , Antígenos CD34/análisis , Biopsia con Aguja Fina , Capilares/patología , Moléculas de Adhesión Celular/análisis , Núcleo Celular/ultraestructura , Diagnóstico Diferencial , Femenino , Estudios de Seguimiento , Células Gigantes/patología , Humanos , Cuerpos de Inclusión Intranucleares/ultraestructura , Proteínas Proto-Oncogénicas c-bcl-2/análisis , Tomografía Computarizada por Rayos X , Vimentina/análisisRESUMEN
Wilms' tumour (WT) is the most common solid tumour of childhood. The molecular signalling pathways determining the origin and behaviour of WT are very complex and several genes in several loci may participate. This review tries to briefly compile recent works on the histology and on the molecular alterations that promote the genesis, development and behaviour of WT. Some molecular alterations seem to be associated with specific histological types and particular clinical outcomes, suggesting that they might be utilised to determine the prognosis and to identify poor prognostic subgroups that can be targeted for more individualised treatments (AU)
No disponible
Asunto(s)
Humanos , Masculino , Femenino , Anomalías Múltiples/genética , Aberraciones Cromosómicas , Genes del Tumor de Wilms , Neoplasias Renales/genética , Tumor de Wilms/diagnóstico , Tumor de Wilms/genética , Neoplasias Renales/patología , Tumor de Wilms/patologíaAsunto(s)
Enfermedades de la Mama , Adolescente , Enfermedades de la Mama/diagnóstico , Niño , Preescolar , Femenino , Humanos , Lactante , MasculinoRESUMEN
No disponible
Asunto(s)
Masculino , Femenino , Niño , Adolescente , Humanos , Enfermedades de la Mama/diagnóstico , Biopsia con Aguja FinaRESUMEN
We reviewed 98 cases of fine needle aspiration of soft tissue tumors with histologic confirmation performed during an eight-year period and propose a working morphologic classification based on the most prominent cytologic features. Six main tumor groups are recognized: myxoid, round cells, spindle cells, pleomorphic cells, polygonal cells and well differentiated. We believe that this classification allows recognition of the most common soft tissue tumors while helping with the differential diagnosis of other neoplasia, primary or secondary, with similar morphology and a similar presentation.
Asunto(s)
Neoplasias de los Tejidos Blandos/patología , Adolescente , Adulto , Anciano , Biopsia con Aguja , Niño , Humanos , Persona de Mediana Edad , Neoplasias de los Tejidos Blandos/clasificaciónRESUMEN
Fibromatosis is the proliferation of connective tissue with local infiltrative growth and a tendency to relapse in contrast with fibrosarcoma which never produces metastases. Two patients, a mother and son diagnosed with fibromatosis of initial cervical location in whom surgical extirpation and complementary radiotherapy were performed. The mother underwent polychemotherapy (adriamicine plus dacarbazine) because of extensive relapse. Definitive resolution was achieved in both cases.
Asunto(s)
Fibroma/genética , Neoplasias de Cabeza y Cuello/genética , Enfermedades Musculares/genética , Neoplasias de los Tejidos Blandos/genética , Neoplasias Torácicas , Neoplasias Torácicas/genética , Adolescente , Adulto , Terapia Combinada , Femenino , Fibroma/terapia , Neoplasias de Cabeza y Cuello/terapia , Humanos , Masculino , Enfermedades Musculares/terapia , Inducción de Remisión , Neoplasias de los Tejidos Blandos/terapia , Neoplasias Torácicas/terapiaRESUMEN
The authors carried out a histochemical study with lectins (Ulex europaeus agglutinin-I [UEA-I], Triticum vulgaris [WGA], Glycine max [SBA], Dolichos biflorus [DBA], and Arachis hypogaea [PNA]) in different thyroid gland conditions (17 benign nodular goiters, three diffuse hyperplasias, five Hashimoto's thyroiditis, 20 follicular adenomas, 14 well-differentiated papillary carcinomas, five well-differentiated follicular carcinomas, and 30 normal thyroids) in order to determine if specific lectin patterns are developed during neoplastic transformation. The results showed that (1) in normal thyroid glands, the lectin, UEA-I, is able to discriminate between follicular cells and C-cells; (2) pathologic follicular epithelium had an increased expression of UEA-I, SBA, and WGA receptors; (3) no lectin or group of lectins allow a distinction between follicular carcinoma and papillary carcinoma; (4) when benign and malignant tumors are compared for UEA-I affinity there is a significantly greater frequency of malignant tumour with UEA-I receptor; and (5) although all investigated lectins have shown receptors in endothelial cells at least in one case, the most constant findings have been obtained with UEA-I and WGA. These findings suggest that lectins are not useful in routine diagnostic pathologic examination; however, in particular cases of follicular carcinoma, UEA-I may be a useful tool for the recognition of small vessels invaded by tumoral cells and the demonstration of fucose residues in malignant tumor cells.