RESUMEN
BACKGROUND: Viral respiratory infections may precipitate type 1 diabetes (T1D). A possible association between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19, and the incidence of T1D is being determined. This study was carried out using Portuguese registries, aiming at examining temporal trends between COVID-19 and T1D. METHODS: Hospital data, comparing the incidence before and during the COVID-19 pandemic, from children and young adults diagnosed with new-onset T1D, was acquired beginning in 2017 and until the end of 2022. Data was obtained from nine different Portuguese hospital units. The impact of the COVID-19 pandemic, beginning in March 2020, was assessed comparing the annual numbers of new-onset T1D cases. The annual median levels of glucose, glycated hemoglobin (HbA1c) and fasting C-peptide at T1D diagnosis were compared. The annual number of diabetic ketoacidosis (DKA) episodes among new T1D cases was also assessed at two centers. RESULTS: In total, data from 574 newly diagnosed T1D patients was analyzed, including 530 (92.3%) children. The mean ages for child and adult patients were 9.1 (SD 4.4) and 32.8 (SD 13.6) years, respectively. 57.8% (331/573) were male, one patient had unknown sex. The overall median (25-75 percentiles) levels of glucose, HbA1c and fasting C-peptide at diagnosis were 454 mg/dL (356-568), 11.8% (10.1-13.4) and 0.50 µg/L (0.30-0.79), respectively. DKA at T1D diagnosis was present in 48.4% (76/157). For eight centers with complete 2018 to 2021 data (all calendar months), no overall significant increase in T1D cases was observed during the COVID-19 pandemic, i.e. 90 cases in 2018, 90 cases in 2019, 112 in 2020 and 100 in 2021 (P for trend = 0.36). Two of the centers, Faro (CHUA) and Dona Estefânia (CHULC) hospitals, did however see an increase in T1D from 2019 to 2020. No significant changes in glucose (P = 0.32), HbA1c (P = 0.68), fasting C-peptide (P = 0.20) or DKA frequency (P = 0.68) at the time of T1D diagnosis were observed over the entire study period. CONCLUSION: The T1D incidence did not increase significantly, when comparing the years before and during the COVID-19 pandemic, nor did key metabolic parameters or number of DKA episodes change.
Asunto(s)
COVID-19 , Diabetes Mellitus Tipo 1 , Sistema de Registros , Humanos , COVID-19/epidemiología , COVID-19/complicaciones , Diabetes Mellitus Tipo 1/epidemiología , Diabetes Mellitus Tipo 1/complicaciones , Masculino , Portugal/epidemiología , Femenino , Incidencia , Niño , Adulto , Adolescente , Adulto Joven , Preescolar , Hemoglobina Glucada/análisis , Hemoglobina Glucada/metabolismo , SARS-CoV-2 , Cetoacidosis Diabética/epidemiología , Glucemia/análisis , Glucemia/metabolismoRESUMEN
Neonatal alloimmune thrombocytopenia (NAIT) and neonatal alloimmune neutropenia (NAIN) may have severe consequences in the neonatal period. We report two dizygotic twins conceived after donated oocytes, suffering NAIT and NAIN in the context of alloantibodies to human platelet antigens (anti-HPA-5b) and human leukocyte antigens (anti-HLA class I). Genotyping demonstrated paternal homozygosity for HPA-5a, while the neonates were heterozygous for HPA-5b.
RESUMEN
OBJECTIVES: To characterize and compare the performance of students at the beginning and at the end of the elementary school in Short-Term Phonological Memory (STPM) and Phonological Awareness (PA). METHODS: We assessed 80 students of both the genders who showed adequate linguistic and academic performance. The sample comprised 40 students in 1st grade and 40 in 5th grade from a public state school with mean age of 6.2 and 9.8 years, respectively. The STPM was assessed using a standardized test of Pseudoword Repetition. PA was assessed through a Sequential Assessment Test (CONFIAS). RESULTS: No difference was found between the students of 1st and 5th years in STPM both in total score and concerning the similarity of the pseudowords. Regarding PA, there was a significant difference among the percentage distribution of correct answers in syllabic and phonemic tasks, and the students from 5th grade presented better performance. CONCLUSION: At the beginning and at the end of the elementary school, there is no difference in STPM performance. On the other hand, there is difference in PA, which highlights the influence of schooling on PA development. The correlation between STPM and PA only in 5th-year students suggests that, at the beginning of literacy, STPM cannot be considered as a predictor to children's performance in PA. Nevertheless, as the schooling advances, there is influence of PA on STPM.
Asunto(s)
Concienciación/fisiología , Memoria a Corto Plazo/fisiología , Brasil , Niño , Femenino , Humanos , Pruebas del Lenguaje , Masculino , Fonética , Percepción del Habla/fisiología , Estudiantes , Aprendizaje Verbal/fisiologíaRESUMEN
RESUMO Objetivos: Caracterizar e comparar o desempenho de escolares no início e término (1° e 5° ano) do Ensino Fundamental I, nas habilidades de Memória de Curto Prazo Fonológica e Consciência Fonológica. Métodos: Foram avaliados 80 escolares, de ambos gêneros, com bom desempenho escolar e linguístico, sendo 40 do 1º ano e 40 do 5º ano de uma escola estadual com média de idade, respectivamente, de 6,2 e 9,8 anos. Para a avaliação da Memória de Curto Prazo Fonológica (MCPF) foi utilizado um teste padronizado de repetição de pseudopalavras. A Consciência Fonológica (CF) foi avaliada por meio de um Instrumento de Avaliação Sequencial - CONFIAS. Resultados: Não houve diferença entre os escolares do 1º e do 5º ano no desempenho em MCPF, tanto na pontuação total quanto em relação à similaridade das pseudopalavras. Quanto à CF, houve diferença significativa entre as distribuições das porcentagens de acertos, tanto no subteste de consciência silábica quanto no de consciência fonêmica nos dois anos escolares, com desempenho superior dos escolares do 5º ano. Conclusão: No início e no término do Ensino Fundamental I, as habilidades de MCPF são semelhantes. O mesmo não acontece para a CF, evidenciando a influência da escolaridade sobre o desenvolvimento da CF. O fato de existir correlação entre MCPF e CF apenas para os escolares do 5º ano sugere que ao início da alfabetização a MCPF não pode ser considerada um preditor para o desempenho das crianças em CF. Entretanto, com o avanço da escolaridade existe influência da CF na MCPF.
ABSTRACT Objectives: To characterize and compare the performance of students at the beginning and at the end of the elementary school in Short-Term Phonological Memory (STPM) and Phonological Awareness (PA). Methods: We assessed 80 students of both the genders who showed adequate linguistic and academic performance. The sample comprised 40 students in 1st grade and 40 in 5th grade from a public state school with mean age of 6.2 and 9.8 years, respectively. The STPM was assessed using a standardized test of Pseudoword Repetition. PA was assessed through a Sequential Assessment Test (CONFIAS). Results: No difference was found between the students of 1st and 5th years in STPM both in total score and concerning the similarity of the pseudowords. Regarding PA, there was a significant difference among the percentage distribution of correct answers in syllabic and phonemic tasks, and the students from 5th grade presented better performance. Conclusion: At the beginning and at the end of the elementary school, there is no difference in STPM performance. On the other hand, there is difference in PA, which highlights the influence of schooling on PA development. The correlation between STPM and PA only in 5th-year students suggests that, at the beginning of literacy, STPM cannot be considered as a predictor to children's performance in PA. Nevertheless, as the schooling advances, there is influence of PA on STPM.
Asunto(s)
Niño , Femenino , Humanos , Masculino , Concienciación/fisiología , Memoria a Corto Plazo/fisiología , Brasil , Pruebas del Lenguaje , Fonética , Estudiantes , Percepción del Habla/fisiología , Aprendizaje Verbal/fisiologíaRESUMEN
Calophyllum brasiliense Cambess, Calophyllaceae, is of great interest in folk medicine and is used in the treatment of various diseases such as diabetes. Granules containing the hydroethanolic extract from the stem bark of C. brasiliense were obtained. The polyphenol content was standardized, and the average weight, disintegration, and the dissolution profiles of the capsules were determined after encapsulation. The capsules had an average weight of 574.5±8.0 mg. In vitro tests showed that the most efficient disintegration profile was in hydrochloric acid buffer (pH 1.2), with a capsule disintegration time within 9 min. The dissolution analysis showed a better uniformity of capsule content release when the test was performed in a hydrochloric acid buffer (pH 1.2), with a maximal release rate at 15 min (giving a polyphenol content of 4.38%, which corresponds to a concentration of 0.0080 mg/mL). In distilled water, the maximal release was reached at 20 min (giving a polyphenol content of 5.41%, which is equivalent to 0.0105 mg/mL). In phosphate buffer, the maximal release of capsule contents was reached at the end of the dissolution assay (30 min), with the lowest amount of released polyphenols (3.61%, which corresponds to a concentration of 0.0070 mg/mL). The encapsulated form of the hydroethanolic extract of C. brasiliense was shown to have the necessary traits of a desirable delivery agent, and the dissolution test was an effective analysis of this material's polyphenol release profile for the specific dosage form.