RESUMEN
The concentrations of the key factors of molecular pathogenesis of prehypertension (angiotensin II, HLDF24, S100b, endothelin, autoantibodies to these molecules, and VEGF) were analyzed in subjects with optimal BP (<120/80 mm Hg) and prehypertension (120-139/80-89 mm Hg). Comparative and correlation analysis of the levels of these molecules was performed. A statistically significant decrease in HLDF24 level in prehypertension in comparison optimal BP was observed. Specific features and interactions between the studied factors in optimal BP and in prehypertension were studied. The mechanisms underlying the observed associations between serum concentration of HLFF24 and the development of prehypertension were discussed.
Asunto(s)
Biomarcadores/sangre , Proteínas de Neoplasias/sangre , Fragmentos de Péptidos/sangre , Prehipertensión/sangre , Angiotensina II/sangre , Autoanticuerpos/sangre , Presión Sanguínea/fisiología , Endotelinas/sangre , Femenino , Humanos , Hipertensión/sangre , Masculino , Persona de Mediana Edad , Subunidad beta de la Proteína de Unión al Calcio S100/sangreRESUMEN
We studied concentrations of angiotensin II, HLDF24 peptide, endothelin proteins, S100B, and autoantibodies to them and serum levels of blood natriuretic peptide in patients with different categories of "normal" arterial BP and hypertension. The relationship between blood levels of the above factors and normotony, pre-hypertension, and hypertension in the examined groups was analyzed. The results suggest that the studied molecular factors can serve as potential predictors of arterial hypertension and used for personalized hypertension risk assessment.
Asunto(s)
Biomarcadores/sangre , Hipertensión/sangre , Prehipertensión/sangre , Adulto , Angiotensina II/sangre , Presión Sanguínea/fisiología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Subunidad beta de la Proteína de Unión al Calcio S100/sangreRESUMEN
The content of S100b protein, HLDF24 peptide, and autoantibodies to these factors in blood serum was measured in healthy individuals (35-64-year-old men and women) with various levels of "normal" BP. Significant differences in the amount of these molecular factors were found in individuals with various categories of BP. We revealed age-related and gender differences in the content of molecular factors in the serum. Our results indicate that variations in the concentration of S100b, HLDF24, and autoantibodies to these factors in blood serum from adult people can serve as a reliable criterion for the risk of arterial hypertension.
Asunto(s)
Autoanticuerpos/sangre , Hipertensión/sangre , Proteínas de Neoplasias/sangre , Subunidad beta de la Proteína de Unión al Calcio S100/sangre , Adulto , Biomarcadores/sangre , Femenino , Voluntarios Sanos , Humanos , Hipertensión/inmunología , Masculino , Persona de Mediana Edad , Fragmentos de Péptidos/sangreRESUMEN
Serum levels of total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides were studied in experimental machinery workers and in reference group. The examinees exposed to occupational hazards demonstrated severe dyslipidemia.
Asunto(s)
Aluminio/toxicidad , Contaminantes Ambientales/toxicidad , Metabolismo de los Lípidos , Ruido/efectos adversos , Exposición Profesional/efectos adversos , Polvo , Dislipidemias/etiología , Dislipidemias/metabolismo , Humanos , Persona de Mediana EdadAsunto(s)
Enfermedades de los Conductos Biliares/etiología , Enfermedad Hepática Inducida por Sustancias y Drogas , Sustancias Peligrosas/efectos adversos , Enfermedades Profesionales/inducido químicamente , Adulto , Femenino , Humanos , Masculino , Persona de Mediana Edad , Enfermedades Profesionales/epidemiología , Federación de Rusia/epidemiología , Factores de TiempoRESUMEN
In 15 patients suffering from ischemic heart disease and in 5 healthy individuals (controls) the dynamics of the blood lipids content (NEFA, triglycerides and atherogenic lipoproteins) was followed up on an empty stomach, during a 18-hour fasting, after carbohydrate and fat loadings, before and after intravenous administration of heparin. Data on a quick and abrupt rise of the NEFA level and a falling triglycerides concentration, and also on a certain decline in the content of atherogenic lipoproteins following administration of heparin were obtained. In atherosclerotic patients the development of hypertriglyceridemia in response to introduction of glucose and a prolonged rise in the level of triglycerides following a fat loading were recorded. Intravenous administration of heparin with carbohydrates and fat loads contributes in atherosclerotic patients to a rapid fall of the blood plasma tryglycerides concentration.