RESUMEN
OBJECTIVE: The objective of this single-use, examiner-blind, two-treatment crossover clinical study was to evaluate the efficacy of a new battery-powered toothbrush (Colgate MicroSonic) relative to that of a currently marketed manual toothbrush (Oral-B Indicator) for the removal of supragingival plaque. This study included the assessment of plaque removal in the whole mouth, at the gumline, and at interproximal sites via the comparison of pre- and post-brushing plaque levels measured using the Rustogi Modification of the Modified Navy Plaque Index. METHODOLOGY: Qualifying adult male and female subjects from the Newark, New Jersey area were provided with a commercially available toothbrush (Colgate Plus Toothbrush) and dentifrice (Colgate Cavity Protection Great Regular Flavor Fluoride Toothpaste) to use at home for three days before beginning the first phase of the crossover study. Subjects returned to the study site after refraining from any oral hygiene procedures for twenty-four hours, and from eating, drinking, or smoking for four hours. Following an examination for supragingival plaque (pre-brushing), they were stratified, based on their plaque scores, into two balanced groups, each of which used the two study toothbrushes in the order specified by a pre-determined randomization plan. Subjects were instructed to brush their teeth for one minute under supervision with their first assigned toothbrush and the commercially available toothpaste provided, after which they were again evaluated for supragingival plaque (post-brushing). Subjects were then dismissed from the study site, and instructed to use the home-use toothbrush and dentifrice. After three days, subjects returned to the study site for the second phase of the crossover study. Pre- and post-brushing evaluations were again performed following the same procedure, with each of the two subject groups now using the second toothbrush in the assigned treatment order. RESULTS: Of the forty-two (42) subjects entered into the study, thirty-nine (39) complied with the protocol and completed the clinical study. The results of the study indicate that the Colgate MicroSonic battery-powered toothbrush provided a statistically significant reduction in pre- to post-brushing plaque index scores of up to 52.9%. Relative to the manual toothbrush, the Colgate MicroSonic battery-powered toothbrush provided a statistically significant greater reduction in supragingival plaque scores of up to 200%. CONCLUSION: The results of this study support the conclusion that the new Colgate MicroSonic battery-powered toothbrush provides a clinically acceptable level of efficacy for the removal of supragingival plaque. Further, the Colgate MicroSonic battery-powered toothbrush exhibited significantly greater levels of efficacy for the removal of supragingival plaque when compared to the Oral-B Indicator Toothbrush.
Asunto(s)
Placa Dental/terapia , Cepillado Dental/instrumentación , Adulto , Cariostáticos/uso terapéutico , Estudios Cruzados , Índice de Placa Dental , Dentífricos/uso terapéutico , Suministros de Energía Eléctrica , Diseño de Equipo , Femenino , Fluoruros/uso terapéutico , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Método Simple Ciego , Resultado del TratamientoRESUMEN
OBJECTIVE: This single-use, examiner-blind clinical study evaluated the efficacy of a newly introduced battery-powered toothbrush (Colgate Motion Toothbrush) relative to a manual toothbrush (Oral-B CrossAction toothbrush) for the removal of supragingival plaque. METHODOLOGY: This study assessed plaque removal via the comparison of pre- and post-brushing plaque levels. A total of 126 adult male and female subjects from the northern New Jersey area reported to the clinical facility for a baseline (pre-brushing) plaque examination after having refrained from all oral hygiene procedures and chewing gum for 24 hours, and from eating, drinking or smoking for four hours. Subjects were entered into the study and stratified into two balanced groups based on their baseline plaque scores. Subjects were instructed to brush their teeth for one minute under supervision with their assigned toothbrush and a commercially available dentifrice, after which they were once again evaluated for supragingival plaque (post-brushing). RESULTS: All 126 subjects completed all aspects of the single-use clinical study. The subjects who used the Colgate Motion toothbrush exhibited a statistically significant 42.1% greater plaque reduction after a single tooth brushing than did those subjects who used the Oral-B CrossAction toothbrush. Relative to the pre-brushing baseline scores, the Colgate Motion toothbrush group exhibited a statistically significant 59.0% reduction in plaque removal. CONCLUSION: The results of this single-use, examiner-blind, clinical study support the conclusion that the battery-powered Colgate Motion toothbrush provides significantly greater efficacy for the removal of supragingival plaque than does the manual Oral-B Cross-Action toothbrush.
Asunto(s)
Placa Dental/terapia , Cepillado Dental/instrumentación , Adulto , Anciano , Análisis de Varianza , Índice de Placa Dental , Electricidad , Diseño de Equipo , Femenino , Humanos , Masculino , Persona de Mediana Edad , New Jersey , Método Simple CiegoRESUMEN
OBJECTIVE: The objective of this single-use, examiner-blind clinical study, was to evaluate the efficacy of a newly designed Colgate Actibrush (battery-powered toothbrush) relative to the Crest SpinBrush (battery-powered toothbrush) for the removal of supragingival plaque. METHODOLOGY: This study included the assessment of plaque removal via the comparison of pre- and post-brushing plaque levels. A total of 80 adult male and female subjects from the central New Jersey area reported to the clinical facility for a baseline (pre-brushing) plaque examination after having refrained from all oral hygiene procedures and chewing gum for 24 hours, and from eating, drinking, or smoking for four hours. Subjects were entered into the study and stratified into two balanced groups based on their baseline plaque scores. Subjects were instructed to brush their teeth for one minute under supervision with their assigned toothbrush and a commercially available toothpaste (Colgate Cavity Protection Great Regular Flavor Fluoride Toothpaste), after which they were once again evaluated for supragingival plaque (post-brushing). RESULTS: All 80 subjects complied with the protocol, and completed the single-use clinical study. The subjects assigned to the Colgate Actibrush group exhibited a statistically significant 44.5% greater whole-mouth plaque reduction after a single brushing than did those subjects assigned to the Crest SpinBrush group. Relative to the pre-brushing baseline scores, the Colgate Actibrush group exhibited a statistically significant 63.7% reduction in whole-mouth plaque removal. CONCLUSION: The results of this single-use, examiner-blind, clinical study support the conclusion that the newly designed Colgate Actibrush provides significantly greater efficacy for the removal of supragingival plaque than does the Crest SpinBrush.
Asunto(s)
Placa Dental/terapia , Cepillado Dental/instrumentación , Adulto , Anciano , Análisis de Varianza , Estudios Cruzados , Índice de Placa Dental , Electricidad , Diseño de Equipo , Femenino , Humanos , Masculino , Persona de Mediana Edad , New Jersey , Método Simple CiegoRESUMEN
BACKGROUND: Dentifrices traditionally have been formulated as pastes or gels. However, liquid varieties recently have become available The authors conducted a study to determine whether a fluoridated liquid product with added triclosan and a polyvinyl methyl ether/maleic acid, or PVM/MA, copolymer delivery system is efficacious for the control of supragingival plaque and gingivitis. METHODS: The authors conducted a six-month, double-blind, parallel, stratified clinical study in accordance with American Dental Association guidelines for the clinical evaluation of antiplaque/antigingivitis products. Subjects who qualified with a suitable amount of existing plaque and gingivitis were given one of two dentifrices: an "experimental" liquid dentifrice containing 0.3 percent triclosan, 2.0 percent PVM/MA copolymer and 0.243 percent sodium fluoride, or NaF, in a silica base; or a "placebo" dentifrice containing 0.243 percent NaF in a silica base. The authors collected subjects' plaque and gingival index scores at baseline, three months and six months. RESULTS: The results of the study indicate that the use of the experimental liquid dentifrice provided a significant reduction in existing levels of plaque and gingivitis as compared with the placebo standard dentifrice. At six months, the experimental group demonstrated a 34.9 percent reduction in plaque formation and a 25.7 percent reduction in gingivitis as compared with the placebo group (P < .001). CONCLUSIONS: When compared with the placebo, the experimental dentifrice had a significantly better ability to reduce plaque and gingivitis. When compared with results reported in the literature, this new form of dentifrice achieved results comparable in efficacy to those of traditional dentifrice pastes with matching active ingredients. CLINICAL IMPLICATIONS: This study confirms that a liquid dentifrice containing a triclosan/copolymer/NaF delivery system is efficacious in its ability to reduce existing plaque and gingivitis.
Asunto(s)
Antiinfecciosos Locales/uso terapéutico , Placa Dental/prevención & control , Dentífricos/uso terapéutico , Gingivitis/prevención & control , Triclosán/uso terapéutico , Adulto , Análisis de Varianza , Antiinfecciosos Locales/administración & dosificación , Cariostáticos/administración & dosificación , Cariostáticos/uso terapéutico , Preparaciones de Acción Retardada , Placa Dental/clasificación , Índice de Placa Dental , Método Doble Ciego , Femenino , Estudios de Seguimiento , Gingivitis/clasificación , Humanos , Masculino , Maleatos , Persona de Mediana Edad , Pomadas , Índice Periodontal , Vehículos Farmacéuticos , Placebos , Polietilenos , Fluoruro de Sodio/administración & dosificación , Fluoruro de Sodio/uso terapéutico , Soluciones , Estadísticas no Paramétricas , Triclosán/administración & dosificaciónRESUMEN
A double-blind, 3-week, randomized, placebo-controlled, parallel-group clinical trial was conducted to evaluate the tooth-whitening efficacy of a novel nontray, "paint-on" liquid whitening gel containing 18% carbamide peroxide (Colgate Simply White Clear Whitening Gel). Efficacy was based on measured Vita tooth-shade scores collected at baseline and after 2 and 3 weeks of product use. Eighty healthy volunteers were balanced into 2 groups based on gender, age, and shade scores (A3 or higher). The duration of product usage was 30 minutes, twice daily, for 3 weeks. Results from this clinical study showed that subjects' teeth in the liquid whitening gel-treated group exhibited an overall mean 3.84-shade improvement and a 3.5-shade difference compared with teeth in the placebo gel group (statistically significant, P < .05) after 3 weeks. Furthermore, this improvement exceeds the minimum requirement to claim "clinical efficacy" as established by the "Guidelines for the Acceptance of Peroxide-Containing Oral Hygiene Products," published by the American Dental Association in 1994. Therefore, it can be concluded that Colgate Simply White Clear Whitening Gel significantly whitens teeth.
Asunto(s)
Dentífricos/uso terapéutico , Blanqueamiento de Dientes , Decoloración de Dientes/tratamiento farmacológico , Adolescente , Adulto , American Dental Association , Análisis de Varianza , Peróxido de Carbamida , Mezclas Complejas , Dispositivos para el Autocuidado Bucal , Método Doble Ciego , Combinación de Medicamentos , Femenino , Geles , Guías como Asunto , Humanos , Masculino , Persona de Mediana Edad , Oxidantes/uso terapéutico , Peróxidos/uso terapéutico , Estados Unidos , Urea/análogos & derivados , Urea/uso terapéuticoRESUMEN
The objective of this double-blind clinical study, conducted in harmony with American Dental Association guidelines, was to compare a new dentifrice formulation variant of Colgate Total Toothpaste containing a special grade of silica (Colgate Total Plus Whitening Toothpaste) to the commercially available, ADA-Accepted and clinically proven Colgate Total Toothpaste for controlling breath odor twelve hours after brushing the teeth. Breath odor was evaluated by a panel of three examiners using a nine-point hedonic scale. Following a baseline evaluation of breath odor, prospective study subjects who scored above the threshold value for unpleasant breath odor were stratified by score and randomized into two treatment groups. Subjects were provided with a soft-bristled toothbrush, and brushed their teeth thoroughly in their regular and customary manner with their assigned dentifrice. Subjects refrained from dental hygiene, breath mints or mounthrinses for the next twelve hours, after which they were again evaluated for breath odor. Eighty-three (83) adult male and female subjects from the Mississauga, Ontario, Canada area participated in the study. At twelve hours after brushing their teeth, subjects in both dentifrice treatment groups presented mean breath odor scores which were statistically significantly lower than the mean scores observed at baseline. Importantly, there was no statistical difference between the two dentifrices of the mean twelve-hour breath odor scores. The mean twelve-hour breath scores for the Colgate Total Plus Whitening Toothpaste group and the Colgate Total Toothpaste group were 4.89 and 4.67, respectively, which are within the range of values corresponding to pleasant breath odor. Thus, the results of this double-blind clinical study, conducted according to a protocol which had been approved by the Council on Scientific Affairs of the American Dental Association, support the conclusion that Colgate Total Plus Whitening Toothpaste and Colgate Total Toothpaste provide effective control of breath odor at twelve hours after toothbrushing.