RESUMEN
The list of sanitary standards with the mark "absent" should include antitumor cytostatics as the drugs satisfying the following criteria: extreme hazard and toxicity, late adverse effects, primarily mutagenic and carcinogenic properties; lack of highly sensitive methods for their determination in water; lack of 100%-efficiency methods for sewage purification. A complex of protective measures is justified and sanitary recommendations are given to protect the aqueous environment during cytostatic production.
Asunto(s)
Antineoplásicos/toxicidad , Industria Farmacéutica/normas , Contaminantes Químicos del Agua/toxicidad , Adulto , Animales , Pruebas de Carcinogenicidad , Femenino , Humanos , Residuos Industriales , Masculino , Ratones , Ratones Endogámicos C3H , Pruebas de Mutagenicidad , Embarazo , Ratas , Ratas Endogámicas F344RESUMEN
Results of experimental substantiation of hygienic standards of 30 drugs in water and analysis of published data showed that drugs should be referred to highly hazardous pollutants of the environment. Criteria and indexes of pharmacologic activity were proposed for use in norm-setting studies.
Asunto(s)
Industria Química , Industria Farmacéutica , Higiene , Contaminantes Químicos del Agua/normas , Animales , Humanos , Dosificación Letal Mediana , Concentración Máxima Admisible , Ratas , Contaminantes del Agua , Contaminantes Químicos del Agua/farmacología , Contaminantes Químicos del Agua/toxicidadRESUMEN
System of calculating methods for staged prognostication of toxicometric parameters and hygienic standards of synthetic drugs was elaborated. This system gives possibility to substantiate quantitative criteria for determination of capacity and directions of investigations in pharmaceutical industry.