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Anticuerpos Monoclonales Humanizados , Artritis Psoriásica , Penfigoide Ampolloso , Psoriasis , Humanos , Anticuerpos Monoclonales Humanizados/uso terapéutico , Artritis Psoriásica/tratamiento farmacológico , Penfigoide Ampolloso/tratamiento farmacológico , Penfigoide Ampolloso/patología , Psoriasis/tratamiento farmacológico , Resultado del Tratamiento , Masculino , Femenino , Persona de Mediana EdadRESUMEN
ABSTRACT: Self-healing juvenile cutaneous mucinosis is a rare entity, characterized by the presence of subcutaneous nodules together with frequent nonspecific systemic symptoms, which occurs in the pediatric age and characteristically resolves spontaneously. Although the diagnostic criteria do not require a biopsy to be performed, it is frequently performed, and an abundant dermal mucin deposition will be observed together with other features such as fibroblastic proliferation. Although the prognosis is benign, follow-up is required for the eventual development of a rheumatologic disease.We present 2 clinical cases, describing the clinical findings and their histopathologic correlation. Comparatively, the outcome in both cases was different: in one case, the mucinosis resolved without any related event in the follow-up, and in the other case, the resolution was accompanied by the subsequent development of idiopathic juvenile arthritis.
Asunto(s)
Artritis Juvenil , Mucinosis , Enfermedades de la Piel , Humanos , Niño , Mucinosis/patología , Biopsia , MucinasRESUMEN
INTRODUCTION: As research continues, new drugs will no doubt be added to the current pool of treatments for moderate-to-severe atopic dermatitis (AD). This raises the need for studies to determine prescriber preferences for different pharmacological options and the factors that influence their choice of treatment. Here we aim to explore physician preferences in the systemic treatment of moderate-to-severe AD, identify the sociodemographic characteristics that can influence physician preferences, and evaluate their satisfaction with current AD therapies. METHODS: A discrete-choice experiment (DCE) survey was administered to physicians treating patients with AD in Spain. Results were analyzed using a conditional logit model to estimate the relative importance of each attribute and the maximum risk accepted to achieve therapeutic benefit. RESULTS: A total of 28 respondents completed the DCE survey (67.9% female, mean age 45.9 years). Participants identified objective clinical efficacy and risk of severe adverse events (AEs) as the most important attributes, followed by improvement in sleep and pruritus and faster onset of action from the start of the treatment. Respondents gave less importance to mode of administration and therapeutic benefit in other atopic conditions. Respondents were willing to accept an increased risk of severe AEs and mild-to-moderate AEs leading to treatment discontinuation due to intolerance in order to obtain improvements in efficacy, sleep, and pruritus, and long-term clinical benefit. CONCLUSION: Our findings can help prescribers choose the most appropriate systemic AD therapy.
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Atopic dermatitis predisposes to skin infections, and on the other hand, some therapies used for atopic dermatitis may worsen viral infections whose lesions may be more diffuse and resistant to treatment. The authors present a patient with severe atopic dermatitis and disseminated molluscum contagiosum infection. The molluscum contagiosum did not clear with topical treatment, and it worsened her atopic dermatitis even more, so the authors started treatment with dupilumab. After two months, the patient's dermatitis went into clinical remission and there was resolution of the infection with no recurrence at the 12-month follow-up. Dupilumab is nowadays a promising treatment for severe atopic dermatitis. To our knowledge, only four reports of molluscum contagiosum during dupilumab therapy have been reported in the literature, with contrasting effects. According to the authors' experience, treatment with dupilumab appears to be a safe alternative for patients with severe atopic dermatitis who are also infected with molluscum contagiosum, as opposed to other treatments such as systemic corticosteroids or cyclosporine.
Asunto(s)
Dermatitis Atópica , Molusco Contagioso , Anticuerpos Monoclonales Humanizados/uso terapéutico , Dermatitis Atópica/complicaciones , Dermatitis Atópica/tratamiento farmacológico , Femenino , Humanos , Molusco Contagioso/tratamiento farmacológicoRESUMEN
Subcutaneous nodules are a rare adverse event following immunization frequently associated with suboptimal injection procedures and aluminium-containing vaccines. We present three cases of subcutaneous nodules following immunization describing their clinical signs, histopathological features and ultrasound findings and demonstrating the use of sonography as an aid to the diagnosis of this entity.
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Inmunización , Neoplasias Cutáneas , Aluminio , Humanos , UltrasonografíaRESUMEN
Abstract Atopic dermatitis predisposes to skin infections, and on the other hand, some therapies used for atopic dermatitis may worsen viral infections whose lesions may be more diffuse and resistant to treatment. The authors present a patient with severe atopic dermatitis and disseminated molluscum contagiosum infection. The molluscum contagiosum did not clear with topical treatment, and it worsened her atopic dermatitis even more, so the authors started treatment with dupilumab. After two months, the patient's dermatitis went into clinical remission and there was resolution of the infection with no recurrence at the 12-month follow-up. Dupilumab is nowadays a promising treatment for severe atopic dermatitis. To our knowledge, only four reports of molluscum contagiosum during dupilumab therapy have been reported in the literature, with contrasting effects. According to the authors' experience, treatment with dupilumab appears to be a safe alternative for patients with severe atopic dermatitis who are also infected with molluscum contagiosum, as opposed to other treatments such as systemic corticosteroids or cyclosporine.
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Double toenail is a rare abnormality that usually affects the fifth toe. It is considered as an inherited condition that may represent an incomplete form of polydactyly. Underlying bone abnormalities should be ruled out. We present a case of a double toenail of the second toe, a location that has not previously been described, with underlying bone involvement noted on ultrasound and plain films.
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Uñas , Dedos del Pie , Humanos , Uñas/diagnóstico por imagen , Radiografía , Dedos del Pie/diagnóstico por imagen , UltrasonografíaAsunto(s)
Muñones de Amputación/patología , Antibacterianos/uso terapéutico , Miembros Artificiales/efectos adversos , Hidradenitis Supurativa/diagnóstico por imagen , Adulto , Muñones de Amputación/diagnóstico por imagen , Clindamicina/uso terapéutico , Doxiciclina/uso terapéutico , Femenino , Hidradenitis Supurativa/tratamiento farmacológico , Hidradenitis Supurativa/etiología , Humanos , UltrasonografíaRESUMEN
No disponible
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Humanos , Masculino , Persona de Mediana Edad , Fungemia/microbiología , Geotricosis/microbiología , Resultado Fatal , Geotricosis/complicaciones , Geotricosis/diagnósticoRESUMEN
No disponible
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Humanos , Masculino , Persona de Mediana Edad , Feohifomicosis/diagnóstico , Trasplante de Riñón/métodos , Trasplante de Pulmón/métodos , Receptores de Trasplantes , Feohifomicosis/sangre , Feohifomicosis/tratamiento farmacológico , Alternaria/patogenicidad , Itraconazol/administración & dosificación , Radiografía Torácica/métodosAsunto(s)
Huésped Inmunocomprometido , Síndromes Paraneoplásicos/diagnóstico , Púrpura/etiología , Síndrome de Sweet/diagnóstico , Humanos , Leucemia Mieloide Aguda/complicaciones , Leucemia Mieloide Aguda/tratamiento farmacológico , Masculino , Persona de Mediana Edad , Síndromes Paraneoplásicos/etiología , Síndrome de Sweet/etiologíaAsunto(s)
Alternariosis , Trasplante de Riñón , Trasplante de Pulmón , Feohifomicosis , Complicaciones Posoperatorias , Alternariosis/diagnóstico , Alternariosis/tratamiento farmacológico , Humanos , Masculino , Persona de Mediana Edad , Feohifomicosis/diagnóstico , Feohifomicosis/tratamiento farmacológico , Complicaciones Posoperatorias/diagnóstico , Complicaciones Posoperatorias/tratamiento farmacológicoRESUMEN
No disponible