RESUMEN

Preoperative oral prophylaxis with nonabsorbable antibiotics has been reported to reduce the risk of surgical site infections after colorectal surgery. This prospective study was conducted to evaluate the risk of toxic side effects by measuring postoperative serum tobramycin levels in patients who received a 3-day prophylaxis with tobramycin and colistin prior to colorectal surgery. In all patients, serum tobramycin concentrations were below the detection limit (0.3 mg/liter), implying a low risk of toxicity.

Asunto(s)

Antibacterianos/efectos adversos , Antibacterianos/uso terapéutico , Profilaxis Antibiótica/métodos , Cirugía Colorrectal/métodos , Tobramicina/efectos adversos , Tobramicina/uso terapéutico , Administración Oral , Anciano , Colistina/efectos adversos , Colistina/uso terapéutico , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , Infección de la Herida Quirúrgica/prevención & control