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In the standard model of particle physics, the weak interaction is described by vector and axial-vector couplings only. Nonzero scalar or tensor interactions would imply an additional contribution to the differential decay rate of the neutron, the Fierz interference term. We derive a limit on this hypothetical term from a measurement using spin-polarized neutrons. This method is statistically less sensitive than the determination from the spectral shape but features much cleaner systematics. We obtain a limit of b=0.017(21) at 68.27% C.L., improving the previous best limit from neutron decay by a factor of four.

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We present a precision measurement of the axial-vector coupling constant g_{A} in the decay of polarized free neutrons. For the first time, a pulsed cold neutron beam was used for this purpose. By this method, leading sources of systematic uncertainty are suppressed. From the electron spectra we obtain λ=g_{A}/g_{V}=-1.27641(45)_{stat}(33)_{sys}, which confirms recent measurements with improved precision. This corresponds to a value of the parity violating beta asymmetry parameter of A_{0}=-0.11985(17)_{stat}(12)_{sys}. We discuss implications on the Cabibbo-Kobayashi-Maskawa matrix element V_{ud} and derive a limit on left-handed tensor interaction.

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This study investigated future medical specialists' objectives of further qualification, their intention, and their decision to establish a practice. Data of 5,053 young physicians, obtained from five German Federal Chambers of Physicians, were analyzed. Data included sociodemographic variables, intended area of specialization, intention, and aspects relevant to the establishment of a practice. Based on preliminary studies, 18 questions were broken down into six factors. The relevance of each of these factors in the decision to establish a practice was analyzed from a gender perspective. Both female and male physicians prioritized general medicine and internal medicine. In addition, female physicians preferred pediatrics and gynecology, while male physicians more frequently chose surgery. Women view professional cooperation opportunities, framework conditions for their family, and job-related commitments as important factors in their decision to establish a practice; quality of life, financial and working conditions are more important to men. The results point out gender-specific approaches which are of relevance for planning medical specialty training.

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AIM OF THE STUDY: Although the estimated need for primary health care is covered to 108% in Germany, a primary care physician shortage is emerging in some regions. Moreover, the number of young physicians completing a specialist medical training for general medicine is decreasing. Therefore the present study aimed to investigate factors influencing young physicians to aspire to such a specialist training as well as aspects considered as important for practice establishment by these physicians. METHODS: 14 939 young physicians aged under 40 years without completed specialist medical training were contacted by mail using databases of five state chambers of physicians (Lower Saxony, Westfalen-Lippe, Saxony, Saxony-Anhalt, Mecklenburg-Western Pomerania). The physicians were asked to answer questions regarding socio-demographic characteristics, the aspired medical speciality, their purpose to establish a practice as well as a questionnaire regarding factors which could be important for the latter decision. The questionnaire had been developed based on qualitative interviews with young physicians and an additional literature search. The answers of 5 053 respondents were eligible for data analysis. The questionnaire regarding factors influencing practice establishment was evaluated using a principal component analysis. Variables predicting the decision for a general medicine specialist training and the weighting of different factors for practice establishment were analysed using logistic or linear regression models. RESULTS: A general medicine specialist training was rather aspired by women, physicians who grew up in rural areas, living with a partner/spouse and having children. No differences were found between physicians living in the Old or New Federal States. Principal component analysis revealed 6 relevant factors for practice establishment. Of these, surrounding conditions for family as well as professional duties (e. g., on-call duty) were most important for the physicians. Opportunities for professional cooperation, working conditions and quality of life in the surrounding area had least importance. On average financial conditions ranged, being for men and physicians without children especially important, but not being influenced by the aspired specialist medical training or the purpose the establish a practice. CONCLUSIONS: The results point to measures which could be suited for rendering the decision-making in favour of the establishment of a primary care practice by young physicians in rural areas more attractive again.

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OBJECTIVE: Impact of caregiver characteristics, patient variables, and regional differences on family burden. METHOD: Two hundred and eighteen schizophrenia patients and key-relatives of an urban and a rural area were examined five times over 30 months. Patients' psychopathology, service utilization; relatives' burden, coping abilities and contact duration with the patients were recorded. Effects of interpersonal differences and intrapersonal changes over time were analyzed with regression models. RESULTS: Interpersonal differences (patients' positive and negative symptoms, relatives' coping abilities, and patient contact) and intrapersonal changes (relatives' coping abilities, patients' negative symptoms and utilization of community care) predicted family burden. CONCLUSION: Family education programs should help caregivers to improve their coping strategies. Therapy solutions must address negative symptoms just as much as positive symptoms, as these especially impact caregivers. Intensified community-based care can reduce burden, but provision alone is not sufficient. Psychiatrists and caregivers should motivate patients to take advantage of such offers.

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AIM OF THE STUDY: Scientists and politicians currently pin great hopes on preventive activities in order to increase the health of particular target populations and to reduce illness related costs. This also holds true for mental disorders, which often show a chronic course of disease. The aim of the present study is to analyse the importance of prevention in social-psychiatric research. METHODS: Including 60 journals, listed in the Science Citation Index or the Social Science Citation Index for the psychosocial field, a systematic literature analysis was done for the year 2004. RESULTS: Only 14 percent of social-psychiatric original research paid attention to prevention. 39 percent of the prevention related publications refer to primary prevention, further 39 percent to secondary prevention, 22 percent focused on tertiary prevention. Research activities concentrated on prevention of substance related disorders as well as early detection or rehabilitation of schizophrenia. CONCLUSIONS: Social psychiatry has only partly responded to the growing importance of prevention in health care. Because many social-psychiatric questions are important for prevention research, social psychiatry should use their competences to facilitate prevention-studies. This holds particularly true for depressive disorders and dementia, which are conditions with high prevalence and substantial illness related costs.

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Patients who show an above-average utilization of medical care are described as "heavy users". Heavy utilization of psychiatric inpatient care could be reduced by well directed community based services. Heavy users should, therefore, be identified at the beginning of a period of heavy service consumption. For this reason, a screening instrument (SPSI) was developed. Six predictors of heavy utilization of inpatient care were included as items in the SPSI. Weighting of items and examination of the instrument were carried out with a sample of 184 schizophrenia patients, whose utilization of inpatient care was recorded prospectively over a period of 30 months. 83 percent of heavy users and 85 percent of ordinary users were correctly identified with the SPSI test at a cutoff score of - 6.7. The SPSI is a short questionnaire which could be used without special rater training in psychiatric care in order to offer identified heavy users well directed community based services, which are less costly than inpatient care, but at least just as appropriate for the special needs of these patients.

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In this paper the impact of the study design and the sampling procedure on the assessment of the costs of schizophrenia treatment will be analyzed. The study sample consists of 307 patients with the diagnosis of schizophrenia (ICD 10F20) with the age between 18 and 65 years. Study participants were recruited consecutively in inpatient and outpatient treatment settings and in accommodation facilities according to the proportions of patients treated in these settings in Leipzig which have been assessed before. Treatment costs have been assessed by means of the German version of the Client Sociodemographic and Service Receipt Inventory at five follow-ups at six-months intervals. For the whole study period significant differences of the mean service costs due to the recruitment setting have been found. The mean yearly costs amounted to 44.669 DM for participants recruited in sheltered accommodation, 27.975 DM for participants in inpatient treatment and 5691 DM for patients in outpatient facilities. A random-effect regression model confirmed significant effects of the recruitment setting over all five follow-ups. Additionally, the variance of costs over time indicates that cost assessment by means of cross sectional data involves the danger of errors due to random dispersion.

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OBJECTIVE: In the project "Cost-effectiveness of psychiatric service systems. A European comparison" a German version of instruments for the assessment of needs for services (CAN-EU), service satisfaction (VSSS-EU) relatives' burden of care (IEQ-EU) and costs of psychiatric services (CSSRI-EU) was developed in close cooperation with the EPSILON Study group. METHOD: The English original versions of the instruments were translated into German and a back-translation into the original language was carried out by a second translator. The back-translation was screened by the first author of the original version. The German versions of all instruments were tested for comprehensibility and practicability by means of focus groups. The internal consistency of all instruments were tested on a representative sample of 307 patients with schizophrenia according to ICD-10 F20. Test-retest reliability and inter-rater reliability was tested by a sub-sample of 50 patients. RESULTS: Psychometric properties of the translated instruments will be presented and discussed. CONCLUSIONS: Statistical methods for the assessment of the reliability coefficients were identical with those of the EPSILON study, therefore the psychometric properties of the German version of the CAN-EU are directly comparable with the other European versions of the instrument.

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OBJECTIVE: The development and the psychometric testing of the German version of the Camberwell Assessment of Need-EU will be presented. METHOD: The internal consistency of the subscales total needs, met needs and unmet needs was tested by the application of the CAN-EU on a representative sample of 307 patients with schizophrenia according to ICD-10 F20.0. Test-retest-reliability and inter-rater-reliability was tested with a sub-sample of 41 patients. RESULTS: The internal consistency and the test-retest-reliability of the German version of the CAN-EU is satisfying and slightly higher in comparison with the other European versions. The inter-rater-reliability is also satisfying but smaller in comparison with the other European versions. CONCLUSIONS: In general, the psychometric properties of the German version of the CAN-EU are satisfying but the lower inter-rater-reliability in comparison with the other European versions suggests that more precise coding rules for the German version of the CAN-EU must be formulated to improve the inter-rater agreement of the instrument.

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AIM: Psychiatric health services research has to consider health economic points of view more than before as a result of the present-day financial problems in our health care system. Therefore an instrument was developed, which is suitable for the evaluation of cost of mental health care in Germany. METHOD: The Client Sociodemographic and Service Receipt Inventory (CSSRI-EU), which was developed in the UK, was adapted to the German situation and for the first time used in a cost-effectiveness-analysis of mental health care. The adaptation process of the instrument and the practical application are explained and pros and cons considered. RESULTS: The German adaptation of the CSSRI-EU has proven effective in practical application. The instrument offers feasible solutions for many problems with the cost of mental health care. The instrument can be used for the calculation of direct and indirect costs and gives information about service utilization and medication profiles of the clients. CONCLUSION: The German adaptation of the CSSRI-EU is a feasible instrument for the evaluation of the cost of mental health care in Germany.

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UNLABELLED: The German Adaptation of the Verona Service Satisfaction Scale: An Instrument for Patients' Satisfaction with Mental Health Care. AIM: Measuring effectiveness and quality of care became an important topic in psychiatry. Considering that objective criteria were not sufficient in the past, the subjective perspective gained growing interest. Client satisfaction is an important variable to evaluate psychiatric care. Patient satisfaction can influence treatment outcome as well as it determines the psychiatric system itself. METHOD: The Italian original version of the Verona Service Satisfaction Scale (VSSS-54) was translated and adapted to the German language. The instrument has been tested in the project "Cost-effectiveness of psychiatric service systems". The process of development, the psychometric testing and the practical application of the German version will be presented in this paper. Additional advantages and disadvantages are discussed. RESULTS: As psychometric properties of the instrument correspond to conventional standards, they are comparable with the results of an international study. The drop out of items cannot be controlled, therefore analysing the data is difficult. CONCLUSION: Although the VSSS shows various methodological limitations, it is at the moment an appropriate instrument for measuring patient satisfaction in the German language.

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AIMS: The German Version of the Involvement Evaluation Questionnaire (IEQ-EU), developed for the assessment of burden on relatives of mentally ill people will be presented. Also the results of the reliability analysis will be presented. METHOD: After translation and adaptation of the Dutch version of the IEQ-EU into German, the instrument was tested in the study "Cost-effectiveness of psychiatric service systems". RESULTS: The internal consistency was tested on a sub-sample of 138 relatives and the Test-Retest-Reliability on a sub-sample of 37 relatives. The internal consistency (Cronbachs alpha) is moderate or good and slightly lower in comparison with the other European versions. With the exception of one subscale the results for the intraclass correlation coefficient are equal to the European versions. CONCLUSIONS: The IEQ-EU is an instrument with moderate or good psychometric properties. It covers all important domains, is easy to understand and not time-consuming.

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OBJECTIVE: Aims of the study are the analysis oft the structures and influence factors causing direct costs of schizophrenic diseases by means of international standardized assessment instruments. METHOD: Annual costs of treatment were assessed for a sample of 258 patients with the diagnosis of schizophrenia (ICD-10 F20) by means of the German version of the CSSRI. For the analysis of cost variance a regression model was computed using functional level (GAF), symptoms (BPRS 4.0), needs for care (CAN), service satisfaction (VSSS) and subjective quality of life (LQoLP) as predictors. RESULTS: The average yearly treatment costs for the study sample were 12 726,- DM. Costs for sheltered accommodation and for psychiatric inpatient treatment were found to be the largest elements of the entire costs followed by the costs for ambulant medications. Results of the regression analysis show that illness history, the severity of symptoms and the need for care explain the greatest proportion of variance. CONCLUSIONS: The standardized instruments developed in the project enable a systematic and international comparable assessment of the costs in the treatment of schizophrenic diseases. Furthermore the instruments allow to explain 38 % of the cost variance. The impact of the severity of symptoms under statistical control of the functional impairment and the needs for care suggests that an effective reduction of symptoms could lead to savings in the entire treatment costs. However, the great influence of the illness history and, irrespective of the functional impairment, the need for care show that the possibilities for cost savings in the treatment of schizophrenia are generally low.

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Affective disorders have a substantial public health impact due to morbidity, mortality, quality of life impairment and economic implications. There has been renewed debate of the efficacy and effectiveness of Lithium in long-term treatment of affective disorders. In the present paper current literature is discussed with a focus on the routine use of Lithium (effectiveness) and on cost aspects. Recent reviews have confirmed the prophylactic efficacy of Lithium in bipolar affective disorders. However, there is some evidence that effectiveness studies do not hold what efficacy research would promise. Non-compliance is likely to be a major reason for this. Lithium response rates have declined in recent studies. This may be related to diagnostic change (broader concept of affective disorders) and more widespread Lithium use. Non-compliance in patients taking Lithium is a primary factor in relapse with substantial cost effects (due to inpatient care). Current studies compare Lithium with Valproic acid/divalproex, and find cost advantages for the latter possibly due to better compliance. A special suicide-preventive effect has only been proven for Lithium. To ensure the full prophylactic potential of Lithium compliance needs to be improved. Future studies will compare Lithium with Valproic acid/divalproex, Carbamazepine and new treatment strategies more detailed.

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For the evaluation of the effectiveness of psychiatric service systems internationally standardised instruments for the assessment of the outcome and the costs of psychiatric and psychosocial treatment and care are increasingly needed. Beside the measurement of objective facts there is a growing importance of the consideration of the subjective perspective of patients and relatives. In the research project "Cost-effectiveness analysis of psychiatric service systems in the European comparison" of the Research association for Public Health in Saxony, developments were worked out, in close cooperation with the BIOMED-2 project "European Psychiatric Services: Inputs Linked to Outcome Domains and Needs", German versions of five European standardized instruments for the assessment of needs for care, treatment satisfaction, burden of care on relatives, quality of life and service costs. The psychometric properties of the instruments were tested within the framework of a longitudinal study with 307 patients with the diagnosis of schizophrenia. As a result of this study, German versions of all relevant European instruments for psychiatric service evaluation are now available.

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OBJECTIVE: The paper examines the development of the Saxonian state mental asylum Leipzig-Dösen in the first half of the twentieth century. METHODS: A rich store of administrative files and case registers allowed us to demonstrate the asylum's history in the field of tension between therapeutic optimism and medical failure. RESULTS: Dösen integrated important structural and therapeutic reforms, had to take care of a rising number of patients with little effective treatment measures and decreasing economic resources and it was involved in most of the inhuman deformities of psychiatry during the period of National Socialism. CONCLUSIONS: The asylums development can be considered as an example for the breakdown of the psychiatric culture in Germany.

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