RESUMEN
We employed a triadic comparison task in patients with Alzheimer's disease (AD) and healthy controls to contrast (a) multidimensional scaling (MDS) and accuracy-based assessments of semantic memory, and (b) degraded-store versus degraded-access accounts of semantic impairment in Alzheimer's disease (AD). Similar to other studies using triadic comparison tasks, participants were asked to indicate which two out of three words (animal names) were most similar in meaning. Novel to this investigation, we contrasted performance on two semantic dimensions of strong and equal saliency to controls, but varying in their specificity (land/water versus bird/non-bird). Degraded-store accounts predict that the more specific bird/non-bird dimension should be more consistently impaired in AD, whereas degraded-access accounts predict that both dimensions, because they are equally salient, should be equivalently impaired in the disorder. The MDS results suggested that both patient and control group responses were not discriminable from random responding, consistent with previous studies. By contrast an accuracy-based analysis on the same data showed that controls showed good knowledge of both salient dimensions, and were evenly split in their individual preference for one dimension over another. In contrast, patients showed higher accuracy and sensitivity to the broader land/water dimension than to the more specific bird/non-bird dimension, consistent with a storage-based account of the semantic impairment in AD. Our results further suggest that MDS methods can fail to reveal important and systematic behaviour in semantic tasks, in both patient and control groups.
Asunto(s)
Enfermedad de Alzheimer/complicaciones , Trastornos del Conocimiento/etiología , Juicio/fisiología , Trastornos del Lenguaje/etiología , Memoria/fisiología , Semántica , Anciano , Femenino , Humanos , Individualidad , Masculino , Persona de Mediana Edad , Pruebas Neuropsicológicas , Análisis de Componente Principal , Escalas de Valoración PsiquiátricaRESUMEN
Using an object decision task, event-related potentials (ERPs), and minimum norm current source estimates, we investigated early spatiotemporal aspects of cortical activation elicited by line drawings that were manipulated on two dimensions: authenticity and typicality. Authentic objects were those that match real-world experience, whereas nonauthentic objects were "doctored" by deletion or addition of features (e.g., a camel with its hump removed, a hammer with two handles). The main manipulation of interest for both authentic and nonauthentic objects was the degree of typicality in the object's structure: typical items are composed of parts that have tended to co-occur across many different objects in the perceiver's experience. The ERP pattern revealed a significant typicality effect at 116 msec after stimulus onset. Both atypical authentic objects (e.g., a camel with its hump) and atypical nonauthentic objects (e.g., a jackal with a hump) elicited stronger brain activation than did objects with typical structure. A significant effect of authenticity was observed at 480 msec, with stronger activation for the nonauthentic objects. The factors of typicality and authenticity interacted at 160 and 330 msec. The most prominent source of the typicality effect was the bilateral occipitotemporal cortex, whereas the interaction and the authenticity effects were mainly observed in the more anterior bilateral temporal cortex. These findings support the hypothesis that within the first few hundred milliseconds after stimulus presentation onset, visual-form-related perceptual and conceptual processes represent distinct but interacting stages in object recognition.
Asunto(s)
Toma de Decisiones/fisiología , Potenciales Evocados , Percepción de Forma/fisiología , Estimulación Luminosa/métodos , Adulto , Femenino , Humanos , Masculino , Lóbulo Occipital/fisiología , Tiempo de Reacción , Reconocimiento en Psicología/fisiología , Lóbulo Temporal/fisiologíaRESUMEN
Considerable controversy exists regarding the relationship between semantic dementia (SD) and progressive aphasia. SD patients present with anomia and impaired word comprehension. The widely used consensus criteria also include the need for patients to exhibit associative agnosia and/or prosopagnosia: many authors have used the label SD for patients with non-verbal, as well as verbal, semantic deficits on formal testing even if they recognize the objects and people encountered in everyday life; others interpret the criterion of agnosia to require pervasive recognition impairments affecting daily life. According to this latter view, SD patients have pathology that disrupts both a bilateral ventrotemporal-fusiform network (resulting in agnosia) and the left hemisphere language network (resulting in profound aphasia). These authors suggest that this profile is different to that seen in the fluent form of primary progressive aphasia (fPPA), a neurodegenerative disease primarily affecting language function. We present data on seven patients who met the diagnostic criteria for fPPA. All seven showed deficits relative to matched controls on both verbal and non-verbal measures of semantic memory, and these deficits were modulated by degree of anomia, concept familiarity and item typicality. Voxel-based morphometry revealed reduced grey matter density in the temporal lobes bilaterally (more widespread on the left), with the severity of atrophy in the left inferior temporal lobe being significantly related to performance on both the verbal and non-verbal measures. Together these findings suggest that patients who meet the diagnostic criteria for fPPA, can also meet the diagnostic criteria for early-stage SD provided that the impact of concept familiarity and typicality is taken into account. In addition, these findings support a claim that the patients' deficits on both verbal and non-verbal tasks reflect progressive deterioration of an amodal integrative semantic memory system critically involving the rostral temporal lobes, rather than a combination of atrophy in the left language network and a separate bilateral ventrotemporal-fusiform network.
Asunto(s)
Demencia/diagnóstico , Anciano , Anciano de 80 o más Años , Afasia Progresiva Primaria/diagnóstico , Afasia Progresiva Primaria/patología , Afasia Progresiva Primaria/psicología , Mapeo Encefálico/métodos , Formación de Concepto , Demencia/patología , Demencia/psicología , Diagnóstico Diferencial , Progresión de la Enfermedad , Femenino , Humanos , Trastornos del Lenguaje/etiología , Imagen por Resonancia Magnética/métodos , Masculino , Trastornos de la Memoria/etiología , Persona de Mediana Edad , Pruebas Neuropsicológicas , Semántica , Lóbulo Temporal/patologíaRESUMEN
Using a speeded lexical decision task, event-related potentials (ERPs), and minimum norm current source estimates, we investigated early spatiotemporal aspects of cortical activation elicited by words and pseudo-words that varied in their orthographic typicality, that is, in the frequency of their component letter pairs (bi-grams) and triplets (tri-grams). At around 100 msec after stimulus onset, the ERP pattern revealed a significant typicality effect, where words and pseudo-words with atypical orthography (e.g., yacht, cacht) elicited stronger brain activation than items characterized by typical spelling patterns (cart, yart). At approximately 200 msec, the ERP pattern revealed a significant lexicality effect, with pseudo-words eliciting stronger brain activity than words. The two main factors interacted significantly at around 160 msec, where words showed a typicality effect but pseudo-words did not. The principal cortical sources of the effects of both typicality and lexicality were localized in the inferior temporal cortex. Around 160 msec, atypical words elicited the stronger source currents in the left anterior inferior temporal cortex, whereas the left perisylvian cortex was the site of greater activation to typical words. Our data support distinct but interactive processing stages in word recognition, with surface features of the stimulus being processed before the word as a meaningful lexical entry. The interaction of typicality and lexicality can be explained by integration of information from the early form-based system and lexicosemantic processes.
Asunto(s)
Corteza Cerebral/fisiología , Potenciales Evocados/fisiología , Fonética , Tiempo de Reacción/fisiología , Reconocimiento en Psicología/fisiología , Escritura , Adolescente , Adulto , Análisis de Varianza , Mapeo Encefálico , Electroencefalografía/métodos , Humanos , Masculino , Pruebas de Asociación de PalabrasRESUMEN
BACKGROUND: Despite the growing recognition of the importance of cognitive symptoms for the diagnosis and management of atypical parkinsonian syndromes, the cognitive assessment of the patients in clinical practice often remains very limited. OBJECTIVES: To examine the ability of a brief and simple cognitive screening test to detect cognitive deficits in atypical parkinsonian syndromes. METHODS: Addenbrooke's cognitive examination (ACE), the mini-mental state examination (MMSE), and the dementia rating scale (DRS) were applied to 26 patients with multiple system atrophy (MSA), 39 with progressive supranuclear palsy (PSP), and 25 with corticobasal degeneration (CBD). The results were then compared with those obtained in 30 healthy age matched volunteers and 30 patients with Alzheimer's disease. RESULTS: In all four diseases the rate of detection of cognitive impairment on ACE was higher than on MMSE and comparable with DRS. The severity of cognitive impairment was most pronounced in the CBD group, which showed a similar degree of impairment to the Alzheimer group. In contrast, MSA patients were the least cognitively impaired. The PSP group took an intermediate position. CONCLUSIONS: Cognitive impairment in atypical parkinsonian syndromes can be detected using a brief and clinically applicable bedside test such as ACE.
Asunto(s)
Trastornos del Conocimiento/diagnóstico , Trastornos del Conocimiento/etiología , Escala del Estado Mental , Trastornos Parkinsonianos/diagnóstico , Trastornos Parkinsonianos/psicología , Sistemas de Atención de Punto , Anciano , Estudios de Casos y Controles , Femenino , Humanos , Masculino , Trastornos Parkinsonianos/complicaciones , Estudios Prospectivos , Sensibilidad y EspecificidadRESUMEN
Rodents exhibit two well-documented behavioural lateralities: spatial preference and paw preference. Waters and Denenberg [36] have identified two seemingly independent factors of paw preference: medial and lateral paw preference. In the present work, the relations among spatial preference (SP), medial paw preference (MPP), and lateral paw preference (LPP) during states of high and low arousal were examined. These preferences were measured in terms of direction, which describes the side of the preference regardless of strength, and degree, which describes the strength of the preference regardless of direction. A strong positive correlation between LPP and SP was found during periods of high, but not low, arousal. A negative correlation between the degree components of LPP and MPP was found during the low, but not high, arousal periods.
Asunto(s)
Nivel de Alerta/fisiología , Pie/fisiología , Lateralidad Funcional/fisiología , Percepción Espacial/fisiología , Animales , Condicionamiento Operante/fisiología , Femenino , Masculino , Aprendizaje por Laberinto/fisiología , Ratones , Ratones Endogámicos BALB CRESUMEN
Two experiments using two inbred strains of mice were conducted to study mouse paw preference. In the first study, 250 (50 x 5) paw reaches from each of 12 male and 12 female C57BL/6J mice were observed over an 8-week period using the Collins paw preference apparatus to investigate questions relating to the independence of reaches, the size of the tube into which the animals reach for flakes of food, and practise effects. Animals appeared to be much more highly lateralized when two independent reaches per day for 25 days (I protocol) were observed than when 50 reaches were observed in a single session (S protocol). Paradoxically, however, we found no evidence for the lack of independence of reaches when we examined the sequences of reaches performed by animals under the S protocol conditions. With practise, animals became slightly more lateralized, but there were no effects of sex, and approximately equal numbers of mice were left-pawed as were right-pawed. The size of the tube had no effect. The second study used 30 BALB mice, each of which was tested with both the I and S protocols, with order of testing counterbalanced. There was a significant protocol x order interaction such that those doing S first were more highly lateralized on the I task, but those doing I first were highly lateralized on both tasks.