RESUMEN

By combining the structural features of dihydropyrimidinone and 1,2,3-triazole heterocycles, novel hybrid compounds were synthesized using a simple and convenient method. A series of novel mono and bis 1,2,3-triazole was synthesized via copper-catalyzed Huisgen azide-alkyne cycloadditions (CuAAC) under microwave irradiation. The newly synthesized compounds were evaluated for their antiviral activity against varicella-zoster virus (VZV). Compounds 6aa, 7ab, 6ba and 6da showed valuable antiviral activities, with EC50 values ranging from 3.6 to 11.3 µM against TK+ and TK- VZV and without measurable cell-growth inhibition.

Asunto(s)

Antivirales/farmacología , Herpesvirus Humano 3/efectos de los fármacos , Pirimidinonas/farmacología , Triazoles/farmacología , Antivirales/síntesis química , Antivirales/química , Proliferación Celular/efectos de los fármacos , Células Cultivadas , Cristalografía por Rayos X , Relación Dosis-Respuesta a Droga , Humanos , Pruebas de Sensibilidad Microbiana , Modelos Moleculares , Estructura Molecular , Pirimidinonas/química , Relación Estructura-Actividad , Triazoles/química