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PURPOSE: E-cigarettes are the most common type of electronic nicotine delivery system in the United States. E-cigarettes contain numerous toxic compounds that has been shown to induce severe structural damage to the airways. The objective of this study is to assess if there is an association between e-cigarette use and respiratory symptoms in adults in the US as reported in the BRFSS. METHODS: We analyzed data from 18,079 adults, 18-44 years, who participated at the Behavioral Risk Factor Surveillance System (BRFSS) in the year 2017. E-cigarette smoking status was categorized as current everyday user, current some days user, former smoker, and never smoker. The frequency of any respiratory symptoms (cough, phlegm, or shortness of breath) was compared. Unadjusted and adjusted logistic regression analysis were used to calculate odds ratios (OR) and 95% confidence intervals (CI). RESULTS: The BRFSS reported prevalence of smoking e-cigarettes was 6%. About 28% of the participants reported any of the respiratory symptoms assessed. The frequency of reported respiratory symptoms was highest among current some days e-cigarette users (45%). After adjusting for selected participant's demographic, socio-economic, and behavioral characteristics, and asthma and COPD status, the odds of reporting respiratory symptoms increased by 49% among those who use e-cigarettes some days (OR 1.49; 95% CI: 1.06-2.11), and by 29% among those who were former users (OR 1.29; 95% CI: 1.07-1.55) compared with those who never used e-cigarettes. No statistically significant association was found for those who used e-cigarettes every day (OR 1.41; 95% CI 0.96-2.08). CONCLUSION: E-cigarettes cannot be considered as a safe alternative to aid quitting use of combustible traditional cigarettes. Cohort studies may shed more evidence on the association between e-cigarette use and respiratory diseases.

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BACKGROUND: Studies in the United States have shown a genetic predisposition to hypertension in individuals of African descent. However, studies on the associations between ethnic groups and hypertension in Latin America are lacking and the limited results have been inconsistent. The objective of this study is to determine whether Afro-Colombian ethnicity increases the risk of hypertension. METHODS: This study is a secondary data analysis of a cross sectional study from five provinces in Northern Colombia. Randomly selected individuals (N = 2613; age-range 18-74 years) enrolled in a health care insurance company underwent physical examinations and completed questionnaires regarding ethnicity, lifestyle, and other risk factors. Hypertension in these patients was determined. Unadjusted and adjusted logistic regression analysis were calculated to determine the association between ethnicity and hypertension. RESULTS: No association between Afro-Colombian ethnicity and hypertension was found (odds ratio [OR], 0.85; 95% confidence interval [CI], 0.66-1.09). As expected, people with a body mass index (BMI) of 30 or higher were at a greater risk of having hypertension (OR, 3.12; 95% CI, 2.35-4.16) compared with those with a normal BMI. CONCLUSIONS: Findings from this study suggest no independent association between Afro-Colombian ethnicity and hypertension. Further research should focus on genotyping or socioeconomic factors such as income level.

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INTRODUCTION: Haitian stroke patients had higher diastolic and mean arterial blood pressures, compared with non-Haitian controls. Therefore, we hypothesized that Haitians would have a higher prevalence of left ventricular hypertrophy and decreased ejection fraction. METHODS: Using the Haitian Stroke Database, a cohort study was conducted. The following transthoracic echocardiographic parameters of 52 Haitians and 111 non-Haitians were compared: left ventricular hypertrophy; ejection fraction; right and left ventricular internal dimension at diastole; and left atrial size. RESULTS: Left ventricular hypertrophy and decreased ejection fraction were more prevalent among Haitians (78% vs. 63%; p=.062 and 21% vs. 13%; p=.173, respectively). Neither reached statistical significance. Left atrial enlargement was significantly more prevalent among non-Haitians (36% vs 15%; p=.007). CONCLUSIONS: Left ventricular hypertrophy and decreased ejection fraction were more prevalent in Haitians, but neither finding reached statistical significance. Larger samples are needed for further understanding of stroke comorbidities in Haitians.

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Non-Hispanic Blacks were shown to have an earlier stage of renal cell carcinoma (RCC) at diagnosis compared to non-Hispanic Whites. It is less clear whether disparities in RCC staging occurs for other minority races/ethnicities. We aimed to assess the association between racial/ethnic minorities and stage at diagnosis of RCC, and test for potential effect modification by histological subtype. Sourced from the Surveillance, Epidemiology and End Results (SEER) database, patients ≥20 years diagnosed with RCC from 2007 to 2015 were included (n = 37 493). Logistic regression analyses were performed to assess the independent association between race/ethnicity [non-Hispanic White, non-Hispanic Black, non-Hispanic Asian Pacific Islander, non-Hispanic American Indian/Alaskan Native (AI/AN) and Hispanic] and advanced RCC stage at diagnosis (i.e. regional spread or distant metastasis). Interaction terms were tested and stratified regression was performed accordingly. Twenty-eight percent of patients had advanced RCC stage at diagnosis. After adjusting for age, gender, year of diagnosis, histological subtype and insurance status, compared to non-Hispanic Whites, non-Hispanic Blacks had lower odds of advanced stage at diagnosis [odds ratio (OR) = 0.79; 95% confidence interval (CI) = 0.72-0.87 for clear cell; OR = 0.48; CI = 0.30-0.78 for chromophobe and OR = 0.26; CI = 0.10-0.35 for other subtypes]. Higher odds of advanced stage at diagnosis were found for non-Hispanic AI/AN in clear cell (OR = 1.27; CI = 1.04-1.55) and for Hispanics in papillary subtypes (OR = 1.58; CI = 1.07-2.33). Racial disparities in the RCC stage at diagnosis varied according to histological subtype. Further investigation on the racial disparities reported is warranted to optimize detection and ultimately improve the prognosis of patients with RCC.

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Physical activity decreases the risk of long-term health consequences including cardiac diseases. According to the American Health Association (AHA), adults should perform at least 75 min of vigorous physical activity (PA) or 150 min of moderate PA per week to impact long-term health. Results of previous studies are varied and have yet to integrate perceived access to facilities with AHA PA guidelines. We investigated whether access to free or low-cost recreational facilities was associated with meeting the AHA PA guidelines. Methodology: This cross-sectional study utilized data extracted from the Family Life, Activity, Sun, Health, and Eating (FLASHE) database collected in 2017 (n = 1,750). The main exposure variable was access to free or low-cost recreational facilities. The main outcome variable was meeting the AHA guidelines of 150 min moderate PA or 75 min vigorous PA per week. Covariates included age, sex, level of education, overall health, BMI, ethnicity, hours of work per week, income, and time living at current address. Unadjusted and adjusted logistic regression analysis were used to calculate measures of odds ratio (OR) and corresponding 95% confidence interval (CI). Results: Of the 1,750 included participants, 61.7% (n = 1,079) reported to have access to recreational facilities. Of those with access to facilities, 69.9% met AHA PA guidelines while 30.4% did not. After adjusting for covariates, participants who reported access to recreational facilities were 42% more likely to meet AHA PA guidelines compared with participants who did not (adjusted OR 1.42; 95% CI 1.14-1.76). Secondary results suggest that healthier individuals were more likely to have met AHA PA guidelines. Conclusions: Having access to free or low-cost recreational facilities such as parks, walking trails, bike paths and courts was associated with meeting the AHA PA guidelines. Increasing prevalence and awareness of neighborhood recreational facilities could assist in access to these facilities and increase the ability of individuals to meet AHA PA guidelines. Future research should determine which types of recreational facilities impact physical activity strongest and discover methods of increasing their awareness.

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BACKGROUND: While it is widely held that obesity is a risk factor for stroke, its role in mortality after stroke is less understood. We aim to examine effects of Body Mass Index (BMI) on in-hospital mortality after non-subarachnoid, subarachnoid, and ischemic stroke. METHODS: Retrospective cohort study. Patients aged ≥18 years, who were hospitalized in Florida hospitals between 2008 and 2012 with a diagnosis of first-time stroke as reported by the Agency for Health Care Administration (AHCA). The main independent variable was BMI category, which was divided into non-overweight/non-obese, obese, and morbidly obese. The primary outcome was the adjusted odds ratio (aOR) for in-hospital mortality for subarachnoid and non-subarachnoid hemorrhagic stroke, and ischemic stroke. Logistic regression modeling was utilized to examine the association between each BMI category and in-hospital mortality, while controlling for several potential confounders. This study was reported in line with the STROCSS criteria. RESULTS: Of the 333,367 patients included in the database, 150,153 (45.0%) patients met inclusion criteria. After adjusting for age, gender, ethnicity and other possible confounders, obese patients were 21% less likely to die during their hospitalization following a first ischemic stroke (0.79 aOR, 0.69-0.92, 95% CI, p = 0.002), and 32% less likely following a first non-subarachnoid hemorrhage (0.68 aOR, 0.57-0.82, 95% CI, p = 0.0001) compared to non-overweight/non-obese counterparts. CONCLUSION: Obese patients are less likely to die during hospitalization following first-time non-subarachnoid hemorrhage and ischemic stroke than non-overweight/non-obese patients. These findings support the "obesity paradox" concept, though more research is needed for recurrent stroke patients.

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ABSTRACT: Electronic nicotine delivery systems (ENDS) are growing in use and many of the health implications with these devices remain unknown. This study aims to assess, using a survey representative of the USA general population, if an association exists between a history of ENDS use and a history of stroke.This cross-sectional study was a secondary data analysis using the 2016 behavioral risk factor surveillance system survey. The main exposure variable of the study was a self-reported history of ENDS use. The main outcome was a self-reported history of stroke. Covariates included sex, race, traditional cigarette use, smokeless tobacco use, chronic kidney disease, diabetes, myocardial infarction, and coronary artery disease. Unadjusted and adjusted logistic regression analyses were done. Adjusted odds ratios (AOR) and their corresponding 95% confidence intervals (CI) were calculated.Of the 486,303 total behavioral risk factor surveillance system survey participants, 465,594 met the inclusion criteria for this study of ENDS use and stroke. This study shows that current ENDS use was positively associated with a history of stroke. AOR of some daily ENDS use with stroke was 1.28 (95% CI: 1.02-1.61) and AOR of current daily ENDS use with stroke was 1.62 (95% CI: 1.18-2.31). The majority (55.9%) of current daily ENDS users reported former traditional cigarette smoking. Female sex, non-white ethnicity, elderly age, chronic kidney disease, coronary artery disease, diabetes, and traditional cigarette use characteristics were all also associated with increased odds of reporting a stroke.This study found a statistically significant and positive association between ENDS use and a history of stroke. Further research is warranted to investigate the reproducibility and temporality of this association. Nevertheless, this study contributes to the growing body of knowledge about the potential cardiovascular concerns related to ENDS use and the need for large cohort studies.

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PURPOSE: Studies have demonstrated a disparity in sexual minority adolescents and substance use, possibly due to factors contributing to minority stress. The objective of this study is to investigate the association between self-identifying as lesbian, gay, or bisexual and illicit substance use compared to those who identify as heterosexual among high school students in the U.S. METHODS: A secondary data analysis of a cross-sectional study was performed using data from the Youth Risk Behavior Surveillance System in 2017. The study included adolescents attending public, Catholic, or private U.S. high schools. Participants with missing data on substance use and sexual orientation were excluded. The final sample size was 12,370. The main outcome variable was illicit substance use, which included marijuana and cocaine, among others. The main exposure variable was students who identified as heterosexual, gay or lesbian, bisexual, and unsure. Binary logistic regression analysis was used to calculate unadjusted and adjusted odds ratios and 95% confidence intervals (CIs). RESULTS: Participants who identified as bisexual had 1.65-fold increased odds (95% CI 1.32-2.05) of ever using illicit substance(s) compared to heterosexuals. Those who identified as "not sure" of their sexual identity had 1.37-fold increased odds of ever using illicit substance(s) compared to heterosexuals (95% CI 1.03-1.83). CONCLUSIONS: The results will provide health professionals with more information about illicit substance use among lesbian, gay, or bisexual identified adolescents. An increase in the understanding of health disparities associated with sexual identity may assist in the development of interventions.

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INTRODUCTION: Total knee arthroplasty (TKA) is common but complex operation. A paucity of literature exists on differences between Hispanics and non-Hispanics with TKA. Our study aims to investigate the association between Hispanic ethnicity and complications in obese patients undergoing TKA. METHODS: This is a retrospective cohort study using the National Surgical Quality Improvement Program database for patients with body mass index ≥30 kg/m2 who underwent TKA. Exposure in this study was ethnicity (Hispanic versus non-Hispanic), and the primary outcome was postoperative complications. Associations between ethnicity and baseline characteristics and between covariates and the outcome were assessed via bivariate analysis. Multiple logistic regression was done to determine associations between Hispanic ethnicity and complications while controlling for confounders. RESULTS: Thirty five thousand twenty-seven patients were included in our study, of which 6.3% were Hispanic. Among obese adults, Hispanics had a 1.24 (95% CI 1.11 to 1.39) times greater odds of having a postoperative complication after TKA than non-Hispanics. This increased to 1.36 (95% CI 1.20 to 1.54) after adjusting for confounders. Hispanics were notably more likely to receive transfusion (2.62% vs. 1.59%, P < 0.001) and have prolonged length of stay (13.29% vs. 11.12%, P = 0.002) but were less likely to have wound disruption (0.05% vs. 0.27%, P = 0.042). CONCLUSION: In a national database, Hispanic ethnicity was associated with greater odds of postoperative complication in obese patients undergoing TKA compared with non-Hispanics. Future studies focusing on a wide range metrics of social determinants of health are needed to further investigate barriers and intervention to eliminate racial/ethnic disparities in surgical patients.

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AIMS: Diabetes currently affects 30.3 million people in the United States. The objective of this study was to investigate the association between taking a course in self-managing diabetes and diabetic ocular complications including diabetic retinopathy diagnosis (OC-RD). METHODS: The sample was from the 2017 CDC's BRFSS participants. We included adults who self-reported they had diabetes. The exposure included those who took a course in how to self-manage diabetes. The outcome was those told they had OC-RD by a doctor. Unadjusted and adjusted logistic regression analysis were used to calculate the odds ratios (OR) and 95% confidence intervals (CI). RESULTS: The odds of OC-RD decreased by 30% for those who did not attend a course compared to those who did (OR 0.70; 95% CI 0.60-0.80). Patients who saw a doctor showed a 50% increase in the odds of OC-RD than those who did not (OR 1.50; 95% CI 1.20-1.90). Those earning above $15,000 had a 10% decreased likelihood of OC-RD every time income level increased. CONCLUSIONS: Taking a class on self-managing diabetes was associated with an increased risk of OC-RD in the diabetic population. Future studies may analyze how education will affect diabetic complications.

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AIMS: To identify if there is an association between socio-economic or demographic factors, lifestyle habits, or chronic conditions and meeting the current exercise recommendations for adult patients with Diabetes Mellitus 2 in the United States. METHODS: This secondary analysis of a cross sectional study used data from participants who reported having diabetes and answered questions regarding physical activity in the 2017 Behavioral Risk Factor Surveillance System survey (n=37,204; 42% women; 30%<60 years-of-age). Respondents were dichotomized according to physical activity adherence. Predictors tested included socioeconomic and demographic characteristics, lifestyle habits, and chronic conditions. Unadjusted and adjusted logistic regression models were used to calculate odds ratios (OR) and 95% confidence intervals (CI). RESULTS: Our data showed that 46.5% of participants with diabetes adhered to the physical activity guidelines. Daily smokers were 25% less likely to adhere to the physical activity recommendations (95% CI 0.59-0.95), patients with obesity were 37% less likely (95% CI 0.53-0.74), and those with chronic kidney disease were 24% (95% CI 0.61-0.94) less likely to do so. The odds of adhering to exercise guidelines were reduced by 20% (95% CI 0.70-0.92), 42% (95% CI 0.49-0.68), and 47% (95% CI 0.32-0.57) in good, fair, and poor health respectively. CONCLUSION: Patients with poor health, daily smoking, obesity, or kidney disease may benefit from targeted interventions to accomplish their physical activity recommendations.

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OBJECTIVE: Physician burnout is increasingly recognized as important for patient safety and physician wellness. Though several studies have examined burnout among medical students, few studies have examined the relationships between coping strategies and burnout. We hoped to preliminarily examine these relationships among first year medical students. METHODS: This cross-sectional study administered to first year medical students uses validated psychologic assessment tools including the COPE inventory and the MIB-HS inventory to assess correlations between the results. Standard correlational statistic methods were used to analyze the data in reaching our conclusions. RESULTS: A total of 167 students participated, including 53% females. The adaptive coping strategy of planning was significantly associated with decreased levels of emotional exhaustion and a preserved sense of personal accomplishment on the burnout assessment survey. Additionally, the adaptive coping strategy of positive reinterpretation/growth was also significantly associated with preservation of the sense of personal accomplishment. CONCLUSION: These results highlight the benefit of using adaptive coping strategies to prevent burnout. These data emphasize the importance of providing students programming during early medical training that encourages students to develop and enhance these strategies to promote wellness while in training and beyond.

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Latinos in the United States experience numerous alcohol-related health disparities. There is accumulating evidence that pre-immigration factors are associated with post-immigration alcohol use, but the explanation for health disparities remains unclear. The present study is a secondary analysis of data from the Recent Latino Immigrant Study (RLIS), the first community-based cohort study to examine the pre- to post-immigration alcohol use trajectories of young adult Latino immigrants during their initial years in the United States. Exploratory analysis and hierarchical multiple logistic regression were performed to assess associations between various pre- and post-immigration factors and alcohol misuse among young adult Latino immigrants early in the immigration process. Using an ecodevelopmental approach, we examined potential social and environmental determinants across multiple levels of influence associated with post-immigration alcohol misuse in this population. The study sample consisted of 474 young adult Latino immigrants between the ages of 18-34. The sample was comprised of the following national/regional origins: Cuban (43%), South American (28.7%), and Central American (28.3%). Approximately half of the sample (49.6%) reported a family history of substance use problems (FHSUP+). Participants who reported FHSUP+ and who engaged in alcohol misuse prior to immigrating to the US were more likely to engage in post-immigration alcohol misuse. Results revealed various social and environmental factors associated with pre-immigration alcohol misuse in this population. Study findings can inform culturally tailored prevention interventions aimed at mitigating problem drinking behaviors among young adult recent Latino immigrants.

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BACKGROUND: As children with attention deficit hyperactivity disorder (ADHD) have shown to be at higher risk of accidents and injury, one may assume that they may also bear a higher likelihood of mild traumatic brain injuries (mTBI). However, the current scientific evidence whether ADHD severity is associated with traumatic brain injuries is controversial. The objective of this study was too assess the association between the severity of ADHD and prevalence of mTBI in 0- to 18-year-old children with ADHD in the United States. METHODS: Cross-sectional study using secondary data gathered in 2009/10 from the National Survey of Children with Special Healthcare Needs. After excluding comorbidity and those with nonspecific attention deficits, the final study population consisted of 10,739 children with ADHD from 40,052 households. The main exposure variable was self-reported ADHD severity (mild, moderate, or severe). The main outcome was mTBI, defined as head injury, traumatic brain injury, and/or concussion). Covariates included age, gender and race, medication status. Unadjusted and adjusted logistic regression analysis were used. RESULTS: Children with more severe ADHD had consistently increased incidences of mTBI. Adjusted logistic regression analysis revealed a statistically significant association between severity of ADHD and occurrence of mTBI. The corresponding odds ratios were 1.57 (95% confidence interval (CI) [1.13, 2.18] for moderate, and 1.79 (95% CI [1.18, 2.72]) for severe ADHD, respectively, compared with mild ADHD. In males, children with moderate and severe ADHD had increased odds of mTBI. The corresponding odds ratio for mTBI in those with moderate ADHD was 1.60 (95% CI [1.07, 2.39]) and 1.86 (95% CI [1.15, 3.00]) for severe ADHD, respectively. No associations between severity and mTBI were found in girls. CONCLUSIONS: As ADHD severity was associated with incidence of mTBI, it is important to identify those who need increased attention and counselling to prevent injury.

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Latinas are often more affected by HIV due to their socio-economic and demographic profiles and are also less likely to receive proper mental health care. Latina immigrants are often even more vulnerable due to socio-economic and cultural factors that place them at higher risk. The current study seeks to examine the association between depression and risky sexual behaviors among adult Latina immigrants from a farm working community in South Miami-Dade County, (Florida, USA). Cross-sectional secondary data analysis was used for responses from a community-based participatory research (CBPR) study. Out of 234 Latina immigrants, 15% reported being depressed and 80% were reported as having engaged in risky sexual behavior. Although no association was found between depression and high-risk sexual behavior, significant secondary findings present associations between risky sexual behavior and low sexual relationship power, interpersonal violence, and relationship status. Implications for future research on depression and risky sexual behaviors among this population are discussed.

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