RESUMEN
A classificação de estado físico ASA (Sociedade Americana de Anestesiologistas) é uma ferramenta importante para a avaliação pré-anestésica do paciente. Assim, é utilizada em diversos estudos por possuir estreita relação com a morbidade e a mortalidade anestésica. Realizou-se tal classificação em 243 pacientes caninos submetidos a procedimentos cirúrgicos em um Hospital Veterinário Universitário. Os resultados obtidos foram os seguintes: ASA I (38; 15,64%), ASA II (53; 21,81%), ASA II emergencial (E) (2; 0,82%), ASA III (78; 32,10%), ASA III E (23; 9,46%), ASA IV (11; 4,53%), ASA IV E (36; 14,81%) e ASA V (2; 0,82%). Verificou-se que a maior parte dos pacientes foram classificados como ASA III (doença sistêmica moderada), o que demonstra que, no serviço analisado, a maioria dos animais submetidos à cirurgia são portadores de enfermidades. A mortalidade foi de 2,46%, com a maioria dos óbitos ocorridos no pós-operatório e em pacientes com emergências. Concluiu-se que, no serviço analisado, os maiores riscos estão relacionados aos pacientes com categorias ASA de maior gravidade, em cirurgias emergenciais e, especialmente, no período pós-operatório.(AU)
The classification ASA (American Society of Anesthesiologists) is an important tool for assessing a patient's pre anesthetic. Thus, it is used in many studies because it has close relation with anesthetic morbidity and mortality. This classification was performed on 243 canine patients undergoing surgical procedures at the Veterinary Teaching Hospital. The results obtained were as follows: ASA I (38, 15.64%), ASA II (53; 21.81%), ASA II Emergency (E) (2; 0.82%), ASA III (78; 32.10%), ASA III E (23; 9.46%), ASA IV (11; 4.53 %), ASA IV E (36; 14.81%), and ASA V (2; 0.82%). Most patients were ASA III (moderate systemic disease), demonstrating that in the analyzed service the most operated animals are carriers of disease. The mortality rate was 2.46%, with most deaths occurring postoperatively and in patients with an emergency. The greatest risks are related to patients with more severe categories of the classification ASA, in emergency surgery, and especially in the postoperative period.(AU)
Asunto(s)
Animales , Perros , Anestesia/clasificación , Anestesia/mortalidad , Anestesia/veterinaria , Perros/cirugía , MortalidadRESUMEN
The use of probiotics to prevent or treat mucosal inflammation has been studied; however, the combined effect of probiotics and prebiotics is unclear. The aim of this study was to test whether oral administration of a synbiotic (Simbioflora®) preparation containing Lactobacillus paracasei, Lactobacillus rhamnosus, Lactobacillus acidophilus and Bifidobacterium lactis plus fructooligosaccharide could help control mucosal inflammation in experimental mucositis induced by 5-fluorouracil (5-FU). Male BALB/c mice were randomly divided into six groups: control (CTL), control + prebiotic (CTL+P), control + synbiotic (CTL+S), mucositis (MUC), mucositis + prebiotic (MUC+P), and mucositis + synbiotic (MUC+S). Mice from the CTL+S, MUC+S, CTL+P, and MUC+P groups received synbiotic or prebiotic daily by oral gavage for 13 days. Mice in the CTL and MUC groups received the same volume of saline. On day 11, mice in the MUC, MUC+P, and MUC+S groups received an intraperitoneal injection of 300 mg/kg 5-FU to induce mucositis. After 72 h, all mice were euthanised. Intestinal permeability, intestinal histology, and biochemical parameters were analysed. Group MUC showed a greater weight loss and increased intestinal permeability (0.020 counts per min [cpm]/g) compared to the CTL group (0.01 cpm/g) P<0.05. Both treatments attenuated weight loss compared to the MUC group. Nonetheless, the synbiotic caused a greater reduction in intestinal permeability (0.012 cpm/g) compared to the MUC (0.020 cpm/g) and MUC+P (0.016 cpm/g) groups P<0.05. Mice in groups MUC+P and MUC+S displayed significant recovery of lesions and maintenance of the mucus layer. There were no differences in the short-chain fatty acid concentrations in the faeces between the MUC and CTL groups (P>0.05). Increased acetate and propionate concentrations were evidenced in the faeces of the MUC+P and MUC+S groups. Only the synbiotic treatment increased the butyrate concentration (P<0.05). The results indicate that administration of synbiotic can decrease mucosal damage caused by mucositis.
Asunto(s)
Mucositis/prevención & control , Simbióticos/administración & dosificación , Administración Oral , Animales , Bifidobacterium animalis/crecimiento & desarrollo , Bifidobacterium animalis/metabolismo , Peso Corporal , Ácidos Grasos Volátiles/análisis , Heces/química , Fluorouracilo/administración & dosificación , Fluorouracilo/toxicidad , Tracto Gastrointestinal/patología , Lactobacillus/crecimiento & desarrollo , Lactobacillus/metabolismo , Ratones Endogámicos BALB C , Mucositis/inducido químicamente , Oligosacáridos/administración & dosificación , Oligosacáridos/metabolismo , Resultado del TratamientoRESUMEN
A classificação de estado físico ASA (Sociedade Americana de Anestesiologistas) é uma ferramenta importante para a avaliação pré-anestésica do paciente. Assim, é utilizada em diversos estudos por possuir estreita relação com a morbidade e a mortalidade anestésica. Realizou-se tal classificação em 243 pacientes caninos submetidos a procedimentos cirúrgicos em um Hospital Veterinário Universitário. Os resultados obtidos foram os seguintes: ASA I (38; 15,64%), ASA II (53; 21,81%), ASA II emergencial (E) (2; 0,82%), ASA III (78; 32,10%), ASA III E (23; 9,46%), ASA IV (11; 4,53%), ASA IV E (36; 14,81%) e ASA V (2; 0,82%). Verificou-se que a maior parte dos pacientes foram classificados como ASA III (doença sistêmica moderada), o que demonstra que, no serviço analisado, a maioria dos animais submetidos à cirurgia são portadores de enfermidades. A mortalidade foi de 2,46%, com a maioria dos óbitos ocorridos no pós-operatório e em pacientes com emergências. Concluiu-se que, no serviço analisado, os maiores riscos estão relacionados aos pacientes com categorias ASA de maior gravidade, em cirurgias emergenciais e, especialmente, no período pós-operatório.(AU)
The classification ASA (American Society of Anesthesiologists) is an important tool for assessing a patient's pre anesthetic. Thus, it is used in many studies because it has close relation with anesthetic morbidity and mortality. This classification was performed on 243 canine patients undergoing surgical procedures at the Veterinary Teaching Hospital. The results obtained were as follows: ASA I (38, 15.64%), ASA II (53; 21.81%), ASA II Emergency (E) (2; 0.82%), ASA III (78; 32.10%), ASA III E (23; 9.46%), ASA IV (11; 4.53 %), ASA IV E (36; 14.81%), and ASA V (2; 0.82%). Most patients were ASA III (moderate systemic disease), demonstrating that in the analyzed service the most operated animals are carriers of disease. The mortality rate was 2.46%, with most deaths occurring postoperatively and in patients with an emergency. The greatest risks are related to patients with more severe categories of the classification ASA, in emergency surgery, and especially in the postoperative period.(AU)
Asunto(s)
Animales , Perros , Anestesia/clasificación , Anestesia/mortalidad , Anestesia/veterinaria , Perros/cirugía , MortalidadRESUMEN
Coumarins are natural and synthetic active ingredients widely applied in diverse types of medicinal treatments, such as cancer, inflammation, infection, and enzyme inhibition (monoamine oxidase B). Dihydrocoumarin compounds are of great interest in organic chemistry due to their structural versatilities and, as part of our investigations concerning the structural characterization of small molecules, this work focuses on crystal structure and spectroscopic characterization of the synthesized and crystallized compound 4-(4-methoxyphenyl)-3,4-dihydro-chromen-2-one (C16H14O3). Additionally, a theoretical calculation was performed using density functional theory to analyze the sites where nucleophilic or electrophilic attack took place and to examine the molecular electrostatic potential surface. Throughout all of these calculations, both density functional theory and Car-Parrinello molecular dynamics were performed by fully optimized geometry. The spectroscopic analysis indicated the presence of aromatic carbons and hydrogen atoms, and also the carbonyl and methoxy groups that were confirmed by the crystallographic structure. The C16H14O3 compound has a non-classical intermolecular interaction of type C-Hâ â â O that drives the molecular arrangement and the crystal packing. Moreover, the main absorbent groups were characterized throughout calculated harmonic vibrational frequencies. Also, natural bond orbital analysis successfully locates the molecular orbital with π-bonding symmetry and the molecular orbital with π* antibonding symmetry. Finally, the gap between highest occupied and lowest unoccupied molecular orbitals implies in a high kinetic stability and low chemical reactivity of title molecule.
RESUMEN
Descreve-se um caso raro de piometra iatrogênica adquirida após ligadura bilateral dos cornos uterinoscomo método contraceptivo em cadela, a qual foi atendida com inapetência e secreção vaginal. Após examefísico, suspeitou-se de piometra de coto, pois a paciente já havia sido castrada, segundo informação obtida naanamnese. Após celiotomia mediana retroumbilical, foi constatada presença dos ovários e quatro segmentosuterinos repletos de pus, demonstrando que os cornos uterinos haviam sido ligados bilateralmente e que a técnicade ovário-histerectomia (OH), que é a mais utilizada na prática clínica veterinária, não havia sido realizada.Provavelmente o cirurgião anterior tentou imitar a ligadura tubária, utilizada para anticoncepção em mulheres, aqual é inadequada para a espécie. Após constatação da piometra, foi realizada OH para tratamento da condição, oque levou à recuperação completa do animal.
We describe a rare case of iatrogenic pyometra acquired after bilateral ligation of the uterine horns asa contraceptive method in a bitch. The animal was admitted with ineptness and vaginal secretion. After physicalexamination we suspected stump pyometra, because the patient had already been neutered, according toinformation obtained in the anamnesis. After retroumbilical median celiotomy the presence of the ovaries, andfour segments of the uterus filled with pus were observed, demonstrating that the uterine horns were ligatedbilaterally and the technique of ovariohysterectomy (OH), which is the most widely used in veterinary clinicalpractice, had not been performed. The previous surgeon probably tried to imitate tubal ligation, used forcontraception in women, which is inadequate for the species. After confirmation of the pyometra, OH wasperformed for treating the condition, and there was complete recovery of the animal.
Asunto(s)
Femenino , Animales , Perros , Perros , Enfermedad Iatrogénica , Piómetra/clasificación , Piómetra/diagnóstico , Piómetra/veterinaria , OvariectomíaRESUMEN
Descreve-se um caso raro de piometra iatrogênica adquirida após ligadura bilateral dos cornos uterinoscomo método contraceptivo em cadela, a qual foi atendida com inapetência e secreção vaginal. Após examefísico, suspeitou-se de piometra de coto, pois a paciente já havia sido castrada, segundo informação obtida naanamnese. Após celiotomia mediana retroumbilical, foi constatada presença dos ovários e quatro segmentosuterinos repletos de pus, demonstrando que os cornos uterinos haviam sido ligados bilateralmente e que a técnicade ovário-histerectomia (OH), que é a mais utilizada na prática clínica veterinária, não havia sido realizada.Provavelmente o cirurgião anterior tentou imitar a ligadura tubária, utilizada para anticoncepção em mulheres, aqual é inadequada para a espécie. Após constatação da piometra, foi realizada OH para tratamento da condição, oque levou à recuperação completa do animal.(AU)
We describe a rare case of iatrogenic pyometra acquired after bilateral ligation of the uterine horns asa contraceptive method in a bitch. The animal was admitted with ineptness and vaginal secretion. After physicalexamination we suspected stump pyometra, because the patient had already been neutered, according toinformation obtained in the anamnesis. After retroumbilical median celiotomy the presence of the ovaries, andfour segments of the uterus filled with pus were observed, demonstrating that the uterine horns were ligatedbilaterally and the technique of ovariohysterectomy (OH), which is the most widely used in veterinary clinicalpractice, had not been performed. The previous surgeon probably tried to imitate tubal ligation, used forcontraception in women, which is inadequate for the species. After confirmation of the pyometra, OH wasperformed for treating the condition, and there was complete recovery of the animal.(AU)
Asunto(s)
Animales , Femenino , Perros , Perros , Piómetra/clasificación , Piómetra/diagnóstico , Piómetra/veterinaria , Enfermedad Iatrogénica , OvariectomíaRESUMEN
O objetivo do experimento foi avaliar a digestibilidade in vitro da matéria seca das silagens de 20 genótipos de sorgo, ensilados aos 104 dias de idade em silos de PVC, com 10cm de diâmetro e 40cm de comprimento. Os silos foram abertos 150 dias após a ensilagem para determinaçäo dos teores e perdas de matéria seca (MS), e da digestibilidade in vitro da matéria seca (DIVMS). As diferenças foram verificadas pelo teste SNK e o delineamento experimental adotado foi o inteiramente ao acaso, com três repetiçöes por tratamento. Os teores de MS das silagens variaram de 23,7 por cento a 31,8 por cento, e todas elas apresentaram pequenas perdas de MS. Näo houve diferença entre as silagens dos vinte genótipos quanto aos teores de MS e perdas de MS, mas houve diferença na DIVMS. Os híbridos C 22 e CMSXS 756 apresentaram os maiores valores (62,8 e 63,0 por cento) e os híbridos 547 e C 11 os menores valores (54,1 e 55,5 por cento de DIVMS, respectivamente
Asunto(s)
Alimentación Animal , Grano Comestible , EnsilajeRESUMEN
The objective of this experiment was to evaluate the nutritive value of 20 sorghum genotype silages. They were ensiled at 104 days of age in laboratory silos made of PVC tubes, which were 40cm in lenght and 10cm in diameter. The silos were opened 150 days after ensiling, and the following characteristics were evaluated: dry matter (DM), DM loss and in vitro dry matter digestibility (IVDMD) A completely randomized design was used, with three replications by treatment and the means were compared using SNK test. The silage DM contents ranged from 23.7 to 31.8% and all of them presented low DM losses. All 20 genotype silages were similar considering the evaluated characteristics, except for IVDMD. The hybrids C22 (62.8%) and CMSXS756 (63.0%) showed the highest values for IVDMD and 547 (54.1%) and C 11(55.5%) the lowest ones.
O objetivo do experimento foi avaliar a digestibilidade in vitro da matéria seca das silagens de 20 genótipos de sorgo, ensilados aos 104 dias de idade em silos de PVC, com 10cm de diâmetro e 40cm de comprimento. Os silos foram abertos 150 dias após a ensilagem para determinação dos teores e perdas de matéria seca (MS), e da digestibilidade in vitro da matéria seca (DIVMS). As diferenças foram verificadas pelo teste SNK e o delineamento experimental adotado foi o inteiramente ao acaso, com três repetições por tratamento. Os teores de MS das silagens variaram de 23,7% a 31,8%, e todas elas apresentaram pequenas perdas de MS. Não houve diferença entre as silagens dos vinte genótipos quanto aos teores de MS e perdas de MS, mas houve diferença na DIVMS. Os híbridos C 22 e CMSXS 756 apresentaram os maiores valores (62,8 e 63,0%) e os híbridos 547 e C 11 os menores valores (54,1 e 55,5%) de DIVMS, respectivamente.