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Melanoma, an aggressive and potentially fatal skin cancer, is constrained by immunosuppression, resistance, and high toxicity in its treatment. Consequently, there is an urgent need for innovative antineoplastic agents. Therefore, this study investigated the antimelanoma potential of guttiferone E (GE). In an allogeneic murine B16 melanoma model, GE was administered subcutaneously and intraperitoneally. Antitumor evaluation included tumor volume/weight measurements and histopathological and immunohistochemical analysis. Furthermore, the toxicity of the treatments was evaluated through body/organ weights, biochemical parameters, and genotoxicity. Subcutaneous administration of 20 mg/kg of GE resulted in a significant reduction in both tumor volume and weight, effectively suppressing melanoma cell proliferation as evidenced by a decrease in mitotic figures. The tumor growth inhibition rate was equivalent to 54%. This treatment upregulated cleaved caspase-3, indicating apoptosis induction. On the other hand, intraperitoneal administration of GE showed no antimelanoma effect. Remarkably, GE treatments exhibited no toxicity, evidenced by non-significant differences in body weight gain, as well as organ weight, biochemical parameters of nephrotoxicity and hepatotoxicity, and genotoxic damage. This study revealed, for the first time, the efficacy of subcutaneous administration of GE in reducing melanoma, in the absence of toxicity. Furthermore, it was observed that the apoptotic signaling pathway is involved in the antimelanoma property of GE. These findings offer valuable insights for further exploring GE's therapeutic applications in melanoma treatment.
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Melanoma Experimental , Ratones Endogámicos C57BL , Animales , Melanoma Experimental/tratamiento farmacológico , Melanoma Experimental/patología , Melanoma Experimental/metabolismo , Apoptosis/efectos de los fármacos , Ratones , Masculino , Antineoplásicos/toxicidad , Antineoplásicos/administración & dosificación , Benzofenonas/farmacología , Benzofenonas/administración & dosificación , Benzofenonas/toxicidad , Neoplasias Cutáneas/tratamiento farmacológico , Neoplasias Cutáneas/patología , Proliferación Celular/efectos de los fármacos , Carga Tumoral/efectos de los fármacos , Línea Celular Tumoral , Inyecciones Subcutáneas , FemeninoRESUMEN
BACKGROUND: Whole-body metaiodobenzylguanidine (131 I-MIBG) scintigraphy is the gold standard method to detect neuroblastoma; however, it depends on radioactive material and is expensive. In contrast, whole-body magnetic resonance imaging (WB-MRI) is affordable in developing countries and has been shown to be effective in the evaluation of solid tumors. This study aimed to compare the sensitivity and specificity of WB-MRI with MIBG in the detection of primary tumors and neuroblastoma metastases. PROCEDURE: This retrospective study enrolled patients with neuroblastoma between 2013 and 2020. All patients underwent WB-MRI and MIBG at intervals of up to 15 days. The results were marked in a table that discriminated anatomical regions for each patient. Two experts evaluated, independently and in anonymity, the WB-MRI images, and two others evaluated MIBG. The results were compared in terms of sensitivity and specificity, for each patient, considering MIBG as the gold standard. This study was approved by the UNIFESP Ethics Committee. RESULTS: Thirty patients with neuroblastoma were enrolled in this study. The age ranged from 1 to 15 years, with a mean of 5.7 years. The interval between exams (WB-MRI and MIBG) ranged from 1 to 13 days, with an average of 6.67 days. Compared to MIBG, WB-MRI presented a sensitivity and specificity greater than or equal to 90% for the detection of primary neuroblastoma in bones and lymph nodes. When we consider the patient without individualizing the anatomical regions, WB-MRI presented sensitivity of 90% and specificity of 73.33%. CONCLUSION: In conclusion, WB-MRI is a sensitive and specific method to detect neuroblastoma in bone and lymph nodes and highly sensible to primary tumor diagnosis, suggesting that this test is a viable alternative in places where MIBG is difficult to access. Studies with a larger number of cases are necessary for definitive conclusions.
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3-Yodobencilguanidina , Neuroblastoma , Humanos , Lactante , Preescolar , Niño , Adolescente , Imagen de Cuerpo Entero , Imagen por Resonancia Magnética , Estudios Retrospectivos , Cintigrafía , Sensibilidad y Especificidad , Neuroblastoma/patologíaRESUMEN
Chronic non-communicable diseases are growing global health problems. The objective of this study was to promote pharmaceutical care for a patient with multimorbidities in order to improve its quality of life. A pharmacotherapeutic follow-up was performed using the SOAP method, registered in the form of clinical evolution, along with laboratory tests, anthropometric measurements and application of validated instruments to assess pharmacological adherence, mental health and quality of life. The report deals with a female patient, 55 years old, obese and dyslipidemic, sedentary, hypertensive, diabetic and on the control phase of breast cancer. Self-medication with antibiotics and a proton pump inhibitor was identified. Despite the good pharmacological adherence, the patient had decompensated diabetes, accompanied by dyslipidemia without treatment and interruption of supplements. After pharmacological and non- pharmacological interventions, the patient showed a significant improvement in the reduction of anthropometric measurements and in biochemical parameters. At the end of the follow-up, pharmaceutical care proved to be fundamental in identifying the patient's health problems, contributing to obtain a more rational pharmacotherapy.
As doenças crônicas não transmissíveis são problemas de saúde globais crescentes. O objetivo deste estudo foi promover a assistência farmacêutica a um paciente com multimorbidades, a fim de melhorar sua qualidade de vida. Foi realizado acompanhamento farmacoterapêutico pelo método SOAP e aplicação de instrumentos validados para avaliar adesão farmacológica, saúde mental e qualidade de vida. O relato trata de uma paciente do sexo feminino, 55 anos, obesa e dislipidêmica, sedentária, hipertensa, diabética e em fase de controle do câncer de mama. Foi identificada automedicação com antibióticos e inibidor de bomba de prótons. Apesar da boa adesão farmacológica, a paciente apresentava diabetes descompensado, acompanhada de dislipidemia sem tratamento e interrupção das suplementações. Após intervenções farmacológicas e não farmacológicas, a paciente apresentou melhora significativa na redução das medidas antropométricas e nos parâmetros bioquímicos. Ao final do acompanhamento, a assistência farmacêutica mostrou-se fundamental na identificação dos problemas de saúde do paciente.
Las enfermedades crónicas no transmisibles constituyen un creciente problema de salud mundial. El objetivo de este estudio fue promover la asistencia farmacéutica a un paciente con multimorbilidades para mejorar su calidad de vida. Se realizó seguimiento farmacoterapéutico por el método SOAP y aplicación de instrumentos validados para evaluar adherencia farmacológica, salud mental y calidad de vida. O relato trata de uma paciente do sexo feminino, 55 anos, obesa e dislipidêmica, sedentária, hipertensa, diabética e em fase de controle do câncer de mama. Se identificó automedicación con antibióticos e inhibidor de la bomba de protones. A pesar del buen cumplimiento farmacológico, la paciente presentó diabetes descompensada, acompañada de dislipidemia no tratada e interrupción de la suplementación. Tras intervenciones farmacológicas y no farmacológicas, la paciente mostró una mejoría significativa en la reducción de las medidas antropométricas y los parámetros bioquímicos. Al final del seguimiento, la asistencia farmacéutica demostró ser fundamental en la identificación de los problemas de salud del paciente.
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Humanos , Femenino , Persona de Mediana Edad , Pacientes , Calidad de Vida , Mujeres , Informes de Casos como Asunto , HipertensiónRESUMEN
OBJECTIVE: The objective of this study was to assess the quality of clinical practice guidelines (CPGs) for the pharmacological treatment of depression along with their recommendations and factors associated with higher quality. DESIGN: We conducted a systematic review that included CPGs for the pharmacological treatment of depression in adults. DATA SOURCES: We searched for publications from 1 January 2011 to 31 December 2021, in MEDLINE, Cochrane Library, Embase, PsycINFO, BVS and 12 other databases and guideline repositories. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: We included CPGs containing recommendations for the pharmacological treatment of depression in adults at outpatient care setting, regardless of whether it met the U.S. National Academy of Medicine criteria, or not. If a CPG included recommendations for both children and adults, they were considered. No language restriction was applied. DATA EXTRACTION AND SYNTHESIS: Data extraction was also conducted independently and in duplicate, a process that was validated in a previous project. The quality of the CPGs and their recommendations were assessed by three independent reviewers using Appraisal of Guidelines for Research and Evaluation (AGREE II) and Appraisal of Guidelines for Research and Evaluation-Recommendations Excellence (AGREE-REX). A CPG was considered to be of high quality if AGREE II Domain 3 was ≥60%; while their recommendations were considered high if AGREE-REX Domain 1 was ≥60%. RESULTS: Seventeen out of 63 (27%) CPGs were classified as high quality, while 7 (11.1%) had high-quality recommendations. The factors associated with higher-scoring CPGs and recommendations in the multiple linear regression analyses were 'Handling of conflicts of interest', 'Multiprofessional team' and 'Type of institution'. 'Inclusion of patient representative in the team' was also associated with higher-quality recommendations. CONCLUSIONS: The involvement of professionals from diverse backgrounds, the handling of conflicts of interest, and the inclusion of patients' perspectives should be prioritised by developers aiming for high-quality CPGs for the treatment of depression.
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Depresión , Medicina , Niño , Adulto , Humanos , Depresión/tratamiento farmacológico , Bases de Datos Factuales , Instituciones de SaludRESUMEN
INTRODUCTION: Depression is a serious and widespread mental health disorder. A significant proportion of patients with depression fail to remit after two antidepressant treatment trials, a condition named treatment-resistant depression (TRD). Clinical practice guidelines (CPGs) are instruments aimed to improve diagnosis and treatment. This study objective is to systematically appraise the quality and elaborate a comparison of high-quality CPGs with high-quality recommendations aimed at TRD. METHODS AND ANALYSIS: We searched several specialized databases and organizations that develop CPGs. Independent researchers assessed the quality of the CPGs and their recommendations using AGREE II and AGREE-REX instruments, respectively. We selected only high-quality CPGs that included definition and recommendations for TRD. We investigated their divergencies and convergencies as well as weak and strong points. RESULTS: Among seven high-quality CPGs with high-quality recommendations only two (Germany's Nationale Versorgungs Leitlinie-NVL and US Department of Veterans Affairs and Department of Defense-VA/DoD) included specific TRD definition and were selected. We found no convergent therapeutic strategy among these two CPGs. Electroconvulsive therapy is recommended by the NVL but not by the VA/DoD, while repetitive transcranial magnetic stimulation is recommended by the VA/DoD but not by the NVL. While the NVL recommends the use of lithium, and a non-routine use of thyroid or other hormones, psychostimulants, and dopaminergic agents the VA/DoD does not even include these drugs among augmentation strategies. Instead, the VA/DoD recommends ketamine or esketamine as augmentation strategies, while the NVL does not mention these drugs. Other differences between these CPGs include antidepressant combination, psychotherapy as a therapeutic augmentation, and evaluation of the need for hospitalization all of which are only recommended by the NVL. CONCLUSIONS: High-quality CPGs for the treatment of depression diverge regarding the definition and use of the term TRD. There is also no convergent approach to TRD from currently high-quality CPGs.
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Depresión , Terapia Electroconvulsiva , Humanos , Depresión/terapia , Depresión/tratamiento farmacológico , Antidepresivos/uso terapéutico , Psicoterapia , LitioRESUMEN
Radiation-induced head and neck sarcoma (RIHNS) is a rare and serious long-term complication of radiotherapy (RT), with poor prognosis and high morbidity and mortality. Diagnosis is based on immunohistochemistry and molecular biomarker analysis, and therapy is usually surgical. Other adjuvant therapies might be considered. This case report aimed to describe the clinical, imaging, histopathological, and therapeutic characteristics of a rare case of RIHNS in the mandible after 21 years of RT. A 68-year-old male patient underwent a partial left parotidectomy in 1995, was diagnosed with pleomorphic adenoma, and after recurrence of the lesion in 2000, underwent an ipsilateral total parotidectomy with adjuvant RT. In May 2021, he complained of an ulcerated nodular lesion on the tongue that extended toward the lower gingiva, associated with oral bleeding and difficulties with swallowing. After biopsy in the gingival margin and histopathological analysis, the diagnosis of high-grade spindle-cell sarcoma was established. Complete surgical resection with microsurgical reconstruction using a fibular osteomusculocutaneous free flap was performed. RIHNS could appear after a period of almost 20 years after RT. Surgical resection with reconstructive surgery was a reliable and feasible therapeutic option that showed favorable clinical results after an appropriate follow-up.
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INTRODUCTION: Depression is a serious and widespread mental health disorder. Although effective treatment does exist, a significant proportion of patients with depression fail to respond to antidepressant treatment trials, a condition named treatment-resistant depression. Efficient approach should be given this condition in order to revert the burden caused by depression. Clinical practice guidelines (CPGs) are evidence-based health promotion instruments to improve diagnosis and treatment. CPGs recommendations for treatment-resistant depression must be trustworthy. The objective of the proposed study is to systematically identify, appraise the quality of CPGs for the treatment of depression and elaborate a synthesis of recommendations for treatment-resistant depression of CPGs considered to be of high quality and with high quality recommendations. METHODS AND ANALYSIS: We will search the databases of organizations, such as PubMed, Embase, Cochrane Library, PsycInfo, and the Virtual Health Library, and organizations that develop CPGs. Three independent researchers will assess the quality of the CPGs and their recommendations using the AGREE II and AGREE-REX instruments, respectively. Given the identification of divergences and convergences as well as weak and strong points among high quality CPGs, our work may help developers, clinicians and eventually patients. ETHICS AND DISSEMINATION: No ethical approval is required for a systematic review, as no patient data will be used. The research results will be disseminated in conferences and submitted to a peer reviewed journal.
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Trastorno Depresivo Resistente al Tratamiento , Fragilidad , Antidepresivos/uso terapéutico , Bases de Datos Factuales , Trastorno Depresivo Resistente al Tratamiento/diagnóstico , Trastorno Depresivo Resistente al Tratamiento/tratamiento farmacológico , Promoción de la Salud , Humanos , Revisiones Sistemáticas como AsuntoRESUMEN
INTRODUCTION: Congenital adrenal hyperplasia (CAH), a genetic disease characterized by defective cortisol synthesis and excessive levels of sex hormones, can cause precocious puberty in both sexes in untreated individuals and virilization in female patients with a 46, XX karyotype. The female paraurethral (Skene's) gland has been reported as prostate analogous. Growth of prostate tissue is associated with androgen production; therefore, prostate-specific antigen (PSA) levels may represent a marker of virilization in 46, XX patients with CAH. OBJECTIVES: To describe PSA levels in 46, XX patients and evaluate whether higher PSA levels are associated with androgenization and the severity of the disease. STUDY DESIGN: Sixty-six patients with CAH and a 46, XX karyotype were included, irrespective of age. Serum PSA, testosterone, 17-hydroxyprogesterone (17-OHP) and androstenedione levels were measured. Patients' age, age at diagnosis, forms of the disease, Prader classification, bone age assessment, sex of rearing, surgery, and the presence of clinical complications were obtained from their medical records. RESULTS: The mean age of patients was 11.45 ± 10.74 years. Forty-three patients (65%) were diagnosed neonatally at a median of 0.08 years (mean 1.47 ± 2.34 years), with registers of 17-OHP measurements (Guthrie test) being available in 51%. Testosterone, 17-OHP and androstenedione were significantly high. PSA was detectable in 25% of cases (levels >0.01 ng/ml), with a mean of 0.03 ± 0.09 ng/ml, and only in patients over five years of age. A correlation was found between PSA and age (p < 0.001), age at diagnosis (p = 0.002), testosterone (p = 0.001) and androstenedione (p = 0.023). There was no correlation between PSA and the forms of CAH or Prader classification. A sub-analysis of the patients over five years of age in whom PSA was detectable also showed that there was a correlation between PSA (p < 0.05) and age at analysis, age at diagnosis, testosterone and androstenedione levels. DISCUSSION: Limitations of this study include the small sample size due to the rareness of the disease, its retrospective nature, the absence of a control group, the fact that the sample was selected at two referral centers, which could have resulted in a selection bias, and the use of different reference values in the different laboratories conducting the PSA tests. CONCLUSIONS: PSA is detectable in 25% of 46, XX patients with CAH, only after five years of age. PSA level increases significantly with age, age at diagnosis, and testosterone and androstenedione levels, confirming a correlation between PSA levels and elevated androgen levels.
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Hiperplasia Suprarrenal Congénita , Antígeno Prostático Específico , 17-alfa-Hidroxiprogesterona , Adolescente , Hiperplasia Suprarrenal Congénita/diagnóstico , Andrógenos , Niño , Preescolar , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Estudios Retrospectivos , Adulto JovenRESUMEN
Pediatric living donor liver transplantation (PLDLT) is a successful therapeutic option for children with chronic and acute liver disease. After early transplant results, many technical advancements were introduced in the field to reduce the rate of complications and improve survival. The aim of this study is to present the outcomes of 975 primary PLDLTs in 3 periods: initial practice (period 1, 29 patients, January 1995 to December 1999), second period (period 2, 331 patients, January 2000 to December 2009), and third period (period 3 [P3], 615 patients, January 2010 to September 2019). Among the technical refinements introduced in P3 are the use of hyperreduced left lateral segment grafts, abdominal wall prosthetic mesh closure, double hepatic artery anastomosis, and increased use of vascular grafts for portal vein reconstruction. The outcomes included significant reductions of hepatic artery thrombosis (HAT), early portal vein thrombosis (EPVT), and retransplantation, with better patient and graft survival in P3. Additional analyses showed that the factors independently associated with worse 90-day patient survival were HAT, EPVT, and increasing Pediatric End-Stage Liver Disease score. In conclusion, the introduction of technical refinements in P3, in addition to improvements in patient care, determined a reduction in EPVT, HAT, and retransplantation. Consequently, patient and graft survival rates increased in all time points studied.
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Enfermedad Hepática en Estado Terminal , Trasplante de Hígado , Niño , Enfermedad Hepática en Estado Terminal/cirugía , Supervivencia de Injerto , Arteria Hepática/cirugía , Humanos , Trasplante de Hígado/efectos adversos , Donadores Vivos , Estudios Retrospectivos , Índice de Severidad de la EnfermedadRESUMEN
Resenhou-se o livro "Entre devaneios e ilusões: educação especial e memórias inclusivas", resultado do Pós-doutoramento de Carlos Fernando França Mosquera. É um ensaio subdividido em dois capítulos. No primeiro, destacou-se a tentativa de reescrever a história da educação especial. No segundo, apresentou-se um ensaio sobre uma pedagogia acerca da relação do objeto de conhecimento (os conteúdos e currículo do Judô), com os aprendizes (pessoas com deficiência visual (DV)), além de relatar a experiência profissional e acadêmica do Projeto Judô, realizado em instituição para pessoas com DV. Foram analisados: 1) Estilo e correção de linguagem; 2) Qualidade das fontes utilizadas; 3) Coerência interna e com a metodologia anunciada; 4) Aprofundamento e atualização da discussão com a literatura; e 5) Contribuições e inovações. A inovação pedagógica é inegável na compreensão filosófica do "vazio" que norteia e motiva a pessoa com deficiência visual e a todos que estão envolvidos no processo inclusivo.
The book "Entre devaneios e ilusões: educação especial e memórias inclusivas", is the result of Carlos Fernando França Mosquera's Post-doctorate. It is an essay divided into two chapters. In the first, the history of special education was highlighted. In the second, an essay on a pedagogyabout the relationship between the object of knowledge (the contents and curriculum of Judo), with apprentices (people with visual impairments), in addition to reporting the professional and academic experience of the Judo Project carried out in institutions for visually impaired people. Were analyzed: 1) Style and language correction; 2) Quality of the sources used; 3) Internal coherence with the announced methodology; 4) Deepening and updating the discussion with the literature; and 5) Contributions and innovations. Pedagogical innovation is undeniable in the philosophical understanding of the "void" that guides and motivates the visually impaired person and everyone involved in the inclusive process.
El libro "Entre devaneios e ilusões: educação especial e memórias inclusivas", resultado del postdoctorado de Carlos Fernando França Mosquera. Es un ensayo de dos capítulos. En el primero, se destaca la historia de la educación especial. En el segundo, el diálogo de una pedagogía sobre la relación del objeto de conocimiento (los contenidos y el currículum del judo), con aprendices (personas con discapacidad visual), también informa la experiencia profesional y académica del Proyecto Judo llevado a cabo en instituciones para personas con discapacidad visual. Se analizaron: 1) Corrección de estilo y lenguaje; 2) Calidad de las fuentes utilizadas; 3) Coherencia interna y con la metodología anunciada; 4) Profundizar y actualizar la discusión con la literatura; y 5) Contribuciones e innovaciones. La innovación pedagógica es innegable en la comprensión filosófica del "vacío" que guía y motiva a la persona con discapacidad visual y a todos los involucrados en el proceso inclusivo.
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RESUMO Este artigo analisou avanços na redução das desigualdades no Brasil durante o período de 2003 a 2015, para além da perspectiva de renda. Os dados refletem que, embora transformações relevantes tenham ocorrido, mesmo assim, o Brasil persiste como um dos países mais desiguais do mundo. Entretanto, ao colocar uma lupa nos dados de acesso a bens e serviços dos 5% e dos 20% mais pobres disponibilizados pela Pesquisa Nacional por Amostra de Domicílios (PNAD), os achados se contrapõem ao lugar comum de que só se promoveu acesso à renda e ao consumo dos mais pobres no período estudado, inexistindo alterações significativas no quadro de acesso a direitos básicos, políticas públicas de educação, saúde e de infraestrutura.
ABSTRACT This article analyzed advances in the reduction of inequalities in Brazil during the period from 2003 to 2015, in addition to the income perspective. The data reflect that, although relevant transformations have occurred, nevertheless, Brazil persists as one of the most unequal countries in the world. However, by placing a magnifying glass on the data about access to goods and services of the poorest 5% and 20% made available by the National Household Sample Survey (PNAD), the findings contradict the commonplace that only access to income and the consumption of the poorest was promoted in the period studied, without significant changes in the framework of access to basic rights, public policies of education, health, and infrastructure.
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OBJECTIVES: The aim of this study was to identify systemic and local risk indicators associated with peri-implantitis. MATERIAL AND METHODS: One hundred eighty-three patients treated with 916 osseointegrated titanium implants, in function for at least 1 year, were included in the present study. The implants were installed at the Foundation for Scientific and Technological Development of Dentistry (FUNDECTO) - University of Sao Paulo (USP) - from 1998 to 2012. Factors related to patient's systemic conditions (heart disorders, hypertension, smoking habits, alcoholism, liver disorders, hepatitis, gastrointestinal disease, diabetes mellitus I and II, hyperthyroidism or hypothyroidism, radiation therapy, chemotherapy, menopause, osteoporosis, active periodontal disease, history of periodontal disease and bruxism), implant's characteristics (location, diameter, length, connection, shape, and antagonist), and clinical parameters (wear facets, periodontal status on the adjacent tooth, plaque accumulation on the adjacent tooth, modified plaque index, sulcus bleeding index, probing depth, bleeding on probing, width of keratinized tissue and marginal recession). RESULTS: An increased risk of 2.2 times for history of periodontal disease (PD), 3.6 times for cemented restorations compared to screw-retained prostheses, 2.4 times when wear facets were displayed on the prosthetic crown and 16.1 times for total rehabilitations when compared to single rehabilitations were found. Logistic regression analysis did not show any association between the implant's characteristics and peri-implantitis. CONCLUSIONS: A history of periodontal disease, cemented prostheses, presences of wear facets on the prosthetic crown and full mouth rehabilitations were identified as risk indicators for peri-implantitis. Implants' characteristics were not related to the presence of peri-implantitis.
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Periimplantitis/etiología , Adulto , Anciano , Anciano de 80 o más Años , Estudios Transversales , Coronas/efectos adversos , Diseño de Prótesis Dental , Femenino , Humanos , Masculino , Persona de Mediana Edad , Boca Edéntula/rehabilitación , Periodontitis/complicaciones , Factores de Riesgo , Desgaste de los Dientes/complicacionesRESUMEN
OBJETIVOS: Avaliar a prevalência e o perfil de sensibilidade aos antimicrobianos de bactérias isoladas de uroculturas de gestantes atendidas no ambulatório do Serviço de Obstetrícia do Hospital Universitário de Santa Maria, Brasil. MÉTODOS: Foi realizado um estudo retrospectivo dos laudos emitidos pelo Laboratório de Análises Clínicas do Hospital Universitário de Santa Maria. Foram incluídas no estudo todas as uroculturas positivas de gestantes atendidas no ambulatório do Serviço de Obstetrícia deste hospital, no período de janeiro a dezembro de 2014. Os testes de identificação dos micro-organismos isolados e os perfis de sensibilidade frente aos antimicrobianos foram efetuados por meio de um sistema automatizado. RESULTADOS: No período do estudo foram identificadas neste laboratório 423 uroculturas positivas provenientes de gestantes. A bactéria Gram negativa Escherichia coli foi a mais prevalente (46,50% das culturas positivas). A segunda bactéria mais frequente foi a Gram positiva Staphylococcus saprophyticus (6,2%). O fungo Candida spp. foi isolado de 94 (21,8%) amostras de urina. Nitrofurantoína e amoxicilina/ácido clavulânico foram os antimicrobianos com menor taxa de resistência por parte de E. coli (91,33% e 90,77% de sensibilidade, respectivamente). Já frente às bactérias Gram positivas prevalentes, ampicilina foi a que mostrou maior sensibilidade. CONCLUSÕES: O perfil de suscetibilidade apresentado neste estudo indica que a escolha para o tratamento da ITU na gestação pode recair em nitrofurantoína e/ou amoxicilina/ácido clavulânico para as bactérias Gram negativas. Tendo em vista a prevalência encontrada, esses antimicrobianos podem ser iniciados empiricamente antes do resultado da urocultura, nos casos de ITU sintomática. Este estudo ratifica, entretanto, a importância da realização da urocultura entre os exames pré-natais e sua repetição no terceiro trimestre da gravidez, tendo em vista a variedade de micro-organismos identificados e os diferentes perfis de sensibilidade aos antimicrobianos testados.
AIMS: To evaluate the prevalence of bacteria in urine cultures of pregnant women seen at the outpatient clinic of the Department of Obstetrics at the University Hospital of Santa Maria, Brazil, and to determine the antibiotic sensitivity profile of these bacteria. METHODS: The reports issued by the Laboratory of Clinical Analysis of the University Hospital of Santa Maria were retrospectively analyzed. All positive urine cultures of pregnant women seen at the Department of Obstetrics from January to December 2014 were included in the study. The tests for the identification of bacterial isolates and their sensitivity profiles were assessed by an automated system. RESULTS: A total of 423 positive urine cultures were detected in the pregnant women. Gram-negative Escherichia coli was the most prevalent microorganism (46.50%). Gram-positive Staphylococcus saprophyticus was the second most prevalent bacterium (6.2%). Candida spp. was isolated from 94 (21.8%) urine samples. Nitrofurantoin and amoxicillin/clavulanic acid showed the lowest antimicrobial resistance against E. coli (91.33% and 90.77%, respectively). Ampicillin had the highest sensitivity among prevalent Gram-positive bacteria. CONCLUSIONS: The sensitivity profile found in this study allows us to suggest nitrofurantoin and/or amoxicillin/clavulanic acid for the treatment of urinary tract infection caused by Gram-negative bacteria during pregnancy. Given the prevalence rates detected in this study, these antimicrobials can be initiated empirically before the urine culture results are known, in the cases of symptomatic urinary tract infection. This study underscores the importance of urine culture in the prenatal period and in the third trimester because of the different microorganisms identified and the different sensitivity to the antimicrobials tested.
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Humanos , Infecciones Urinarias , Embarazo , Pruebas de Sensibilidad MicrobianaRESUMEN
It aims at knowing elderly family care after fall accidents. Method: qualitative approach and ecologic insertion method, based on Ecologic Theory of Systems. Results: it has been identified that the family plays an important role in the recovery of impaired elderly, once it offers affective support, necessary for the development of this group. The vicissitudes suffered by the elderly - in this case fall accidents - bring the families together, promoting a restructuration of family bounds and of the activities developed by each member of this core. Conclusion: getting to know family care devoted to elderly after fall accidents elucidates tools helping health professionals to orientate their attention beyond these individuals, trying to understand family functioning as an essential component for service planning towards therapeutic success...
Conhecer o cuidado familiar dedicado ao idoso após o acidente por quedas. Método: abordagem qualitativa e o método utilizado foi inserção ecológica, fundamentada na Teoria dos Sistemas Ecológicos. Resultados: identificou-se que a família executa um importante papel para recuperação do idoso fragilizado, sendo que ela oferece suporte afetivo necessário para o desenvolvimento desse grupo. As intercorrências que acometem os idosos - nesse caso o acidente por quedas - fazem com que as famílias se aproximem, promovendo, assim, uma reestruturação do vínculo familiar e das atividades desenvolvidas por cada membro constituinte desse núcleo. Conclusão: conclui-se que conhecer o cuidado familiar dedicado ao idoso após acidente por queda instrumentaliza e auxilia os profissionais de saúde a direcionarem seu olhar para além dos indivíduos, buscando compreender a funcionalidade familiar como um componente essencial do planejamento assistencial para o alcance do sucesso terapêutico...
Conocer el cuidado familiar dedicado al mayor tras el accidente por caídas. Método: enfoque cualitativo y el método de la inserción ecológica fundamentada en la teoría de los sistemas ecológicos. Resultados: se identificó que la familia ejecuta un importante rol para la recuperación del mayor debilitado, por lo que ofrece soporte afectivo necesario para el desarrollo de ese grupo. Las complicaciones que acometen al mayor, enese caso, el accidente por caídas, hacen con que las familias se aproximen, promoviendo una reestructuración del vínculo familiar. Conclusión: se concluye que conocer el cuidado familiar dedicado al mayor, tras accidente por caída instrumentaliza y auxilia a los profesionales de la salud a direccionar su mirada más allá de los individuos, en la búsqueda por entender la funcionalidad familiar como componente esencial del planeamiento asistencial para el alcance del suceso terapéutico...
Asunto(s)
Humanos , Anciano , Accidentes por Caídas , Cuidadores , Familia , Humanización de la Atención , BrasilRESUMEN
BACKGROUND: Hepatic artery thrombosis (HAT) increases morbidity and mortality after liver transplantation (LT). The identification of risk factors for HAT may aid transplant teams in the development of strategies aimed at reducing HAT. This article describes the risk factors for HAT and outcomes after LT. METHODS: This report describes a retrospective study (1995 to 2015) of primary pediatric living donor LT (LDLT). Pretransplant and technical variables were included in the study. Binary logistic regression was used for data analysis. RESULTS: This study included 656 primary LDLT. The median age, body weight, and pediatric end-stage liver disease score at the time of transplant were 13 months, 8.4 kg and 15, respectively. Twenty-one (3.2%) patients developed HAT. Intraoperative HAT (odds ratio, 62.63; 95% confidence interval, 12.64-310.19; P < 0.001) and the use of liver grafts with a graft-to-recipient weight ratio less than 1.1% (odds ratio, 24.46; 95% confidence interval, 4.55-131.56; P < 0.001) retained statistical significance in the multivariate model. Patient and graft survivals were significantly worse in cases with HAT. The overtime trend analysis revealed a decrease in the incidence of HAT (P = 0.008) and an increase in the use of 2-arterial anastomosis (P < 0.001). CONCLUSIONS: A graft-to-recipient weight ratio of 1.1% or less and intraoperative HAT were independently associated with HAT. Trend analysis further revealed a significant reduction in the incidence of HAT over time, as well as the increased use of 2 hepatic arteries for anastomosis during graft implantation. The double artery anastomosis may represent an extra protection to pediatric recipients undergoing LDLT.
Asunto(s)
Arteria Hepática/cirugía , Trasplante de Hígado/métodos , Donadores Vivos , Trombosis/patología , Adolescente , Adulto , Anastomosis Quirúrgica , Anticoagulantes/química , Peso Corporal , Niño , Preescolar , Selección de Donante , Femenino , Supervivencia de Injerto , Humanos , Lactante , Estimación de Kaplan-Meier , Hígado/cirugía , Masculino , Persona de Mediana Edad , Análisis Multivariante , Oportunidad Relativa , Análisis de Regresión , Estudios Retrospectivos , Factores de Riesgo , Factores de Tiempo , Resultado del Tratamiento , Procedimientos Quirúrgicos Vasculares/métodos , Adulto JovenRESUMEN
Objetivos: avaliar se a união entre implantes e/ou a presença de gengiva artifi cial infl uencia no sangramento a sondagem dos tecidos peri-implantares. Material e métodos: foram incluídos pacientes tratados com implantes de titânio (Implacil De Bortoli, São Paulo, Brasil), instalados no período de 1998 a 2012, na Universidade de São Paulo (USP). Os implantes foram examinados para avaliação do sangramento a sondagem, sendo divididos de acordo com o tipo de prótese: unitárias (n=167), parciais (n=522) e totais (n=227); e de acordo com a ausência (n=674) ou presença (n=242) de gengiva artifi cial. O teste estatístico com equação de estimativa generalizada foi usado para testar possíveis associações. Resultados: foram examinados 183 pacientes reabilitados com 916 implantes em função, pelo menos por um ano. Ao menos um ponto de sangramento a sondagem foi detectado em 85 (50,9%), 304 (58,2%) e 129 (56,8%) implantes das próteses unitárias, parciais e totais, respectivamente. Em relação à gengiva artificial, 378 (56,1%) dos implantes sem e 140 (57,9%) dos implantes com esta característica apresentaram sangramento a sondagem. Não foram verificadas diferenças significativas entre os grupos. Conclusão: a união dos implantes ou a presença de gengiva artificial não foram associadas com os resultados de sangramento a sondagem nos implantes em função.
Objective: to evaluate whether the prosthesis type (single, partial, complete) and/or the presence of artifi cial gingiva can influence on bleeding on probing of peri-implant tissues. Material and methods: patients treated with titanium dental implants (Implacil De Bortoli, São Paulo, Brazil) between 1998 to 2012 at the University of Sao Paulo (USP) were included in this study. The implants were divided according the following prosthodontic types: single (n=167), partial (n=522), and complete (n=277), and also regarding the presence (n=674) or absence (n=242) or artificial gingiva. The generalized estimating equation test was used to verify possible associations. Results: 183 patients and 916 implants at least 1 year in function were screened. At least one bleeding point was detected in 85 (50.9%), 304 (58.2%), and 129 (56.8%) implants for single, partial, and complete prostheses, respectively. 378 (56.1%) and 140 (57.9%) implant from groups without and with artificial gingiva presented bleeding on probing. No significant differences were identified among groups. Conclusion: the prosthesis design and/or artifi cial gingiva were not associated to bleeding on probing for dental implants in function.
Asunto(s)
Humanos , Adulto , Persona de Mediana Edad , Anciano , Anciano de 80 o más Años , Implantes Dentales/estadística & datos numéricos , Prótesis Dental de Soporte Implantado , Encía , Periimplantitis/complicaciones , Enfermedades PeriodontalesRESUMEN
CONTEXT: Staphylococcal scalded skin syndrome is an exfoliative skin disease. Reports of this syndrome in newborns caused by methicillin-resistant Staphylococcus aureus are rare but, when present, rapid diagnosis and treatment is required in order to decrease morbidity and mortality. CASE REPORT: A premature newly born girl weighing 1,520 g, born with a gestational age of 29 weeks and 4 days, developed staphylococcal scalded skin syndrome on the fifth day of life. Cultures on blood samples collected on the first and fourth days were negative, but Pseudomonas aeruginosa and Enterococcus sp. (vancomycin-sensitive) developed in blood cultures performed on the day of death (seventh day), and Pseudomonas aeruginosa and Serratia marcescens were identified in cultures on nasopharyngeal, buttock and abdominal secretions. In addition to these two Gram-negative bacilli, methicillin-resistant Staphylococcus aureus was isolated in a culture on the umbilical stump (seventh day). The diagnosis of staphylococcal scalded skin syndrome was based on clinical criteria.
Asunto(s)
Enfermedades del Prematuro/microbiología , Staphylococcus aureus Resistente a Meticilina/aislamiento & purificación , Síndrome Estafilocócico de la Piel Escaldada/microbiología , Bacteriemia , Resultado Fatal , Femenino , Humanos , Recién Nacido , Recien Nacido PrematuroRESUMEN
CONTEXT: Staphylococcal scalded skin syndrome is an exfoliative skin disease. Reports of this syndrome in newborns caused by methicillin-resistant Staphylococcus aureus are rare but, when present, rapid diagnosis and treatment is required in order to decrease morbidity and mortality. CASE REPORT: A premature newly born girl weighing 1,520 g, born with a gestational age of 29 weeks and 4 days, developed staphylococcal scalded skin syndrome on the fifth day of life. Cultures on blood samples collected on the first and fourth days were negative, but Pseudomonas aeruginosa and Enterococcus sp. (vancomycin-sensitive) developed in blood cultures performed on the day of death (seventh day), and Pseudomonas aeruginosa and Serratia marcescens were identified in cultures on nasopharyngeal, buttock and abdominal secretions. In addition to these two Gram-negative bacilli, methicillin-resistant Staphylococcus aureus was isolated in a culture on the umbilical stump (seventh day). The diagnosis of staphylococcal scalded skin syndrome was based on clinical criteria.
CONTEXTO: A síndrome da pele escaldada estafilocócica é uma doença esfoliativa de pele. São raros os relatos desta síndrome causada por Staphylococcus aureusresistente à meticilina em neonatos, mas, quando presentes, exigem diagnóstico e tratamento rápidos para diminuir a morbidade e mortalidade. RELATO DE CASO: Uma menina recém-nascida prematura, pesando 1.520 g ao nascimento, com idade gestacional de 29 semanas e 4 dias, desenvolveu síndrome da pele escaldada estafilocócica no quinto dia de vida. As culturas de sangue coletadas no primeiro e quarto dias foram negativas, mas houve desenvolvimento de Pseudomonas aeruginosa e Enterococcus sp. (vancomicina sensível) na hemocultura realizada no dia do óbito (sétimo dia) e Pseudomonas aeruginosa e Serratia marcescens foram identificadas nas culturas de secreção da nasofaringe, nádega e da secreção abdominal. Na cultura do coto umbilical (sétimo dia), além desses dois bacilos Gram-negativos, foi isolado o Staphylococcus aureus resistente à meticilina. O diagnóstico da síndrome da pele escaldada estafilocócica foi baseado em critério clínico.
Asunto(s)
Femenino , Humanos , Recién Nacido , Enfermedades del Prematuro/microbiología , Staphylococcus aureus Resistente a Meticilina/aislamiento & purificación , Síndrome Estafilocócico de la Piel Escaldada/microbiología , Bacteriemia , Resultado Fatal , Recien Nacido PrematuroRESUMEN
Objetivo: avaliar retrospectivamente a relação da extensão da reabilitação protética com o índice de placa modificado. Material e métodos: pacientes tratados com implantes (Implacil De Bortoli, São Paulo, Brasil) na Fundecto (USP), no período de 1998 a 2012, foram incluídos neste estudo. Três grupos foram formados, de acordo com a extensão da reabilitação protética (unitária, parcial ou total). O parâmetro clínico índice de placa modificado foi utilizado para comparação entre os grupos. Para análise estatística, a equação de estimativa generalizada (GEE) foi utilizada. Resultados: foram examinados 183 pacientes, reabilitados com 916 implantes em função por pelo menos um ano. A taxa de sobrevivência dos implantes foi de 98,28%. Observou-se que havia placa bacteriana abundante (escore 3) ao redor de 30% (n=68) dos componentes protéticos de implantes pilares de reabilitações totais fixas sobre implantes. Já para os grupos de reabilitações parciais e unitárias, os valores foram de 3,6% (n=19) e 0,6% (n=1), respectivamente. Conclusão: componentes protéticos de implantes pilares de próteses totais fixas implantossuportadas apresentaram maior acúmulo de placa bacteriana abundante em sua superfície.
Objective: to retrospectively evaluate the relationship between the extent of prosthetic rehabilitation with modified plaque index. Material and methods: patients treated with osseointegrated implants (Implacil De Bortoli, Sao Paulo, Brazil) at Fundecto (USP) from 1998 to 2012 were included in this study. Three groups were formed according to the extent of prosthetic rehabilitation (single, partial or total). The modified plaque index was used for comparison among groups. Generalized estimating (GEE) equation was used for statistical evaluation. Results: 183 patients with 916 implants with at least 1 year in function were examined. The implant survival rate was 98.28%. Abundant soft matter (score 3) around 30% (n=68) of the prosthetic abutments from implants supporting total rehabilitations was seen. For the groups that comprised partial and single rehabilitations, the values were 3.6% (n=19) and 0.6% (n=1), respectively. Conclusion: prosthetic abutments from implants supporting total rehabilitations presented the greatest values for abundant bacterial plaque accumulation.